scholarly journals Portulaca Oleracea L. Extract Ameliorates Intestinal Inflammation by Regulating Endoplasmic Reticulum Stress and Autophagy

2021 ◽  
pp. 2100791
Author(s):  
Ziwei Zhang ◽  
Dan Qiao ◽  
Yali Zhang ◽  
Qian Chen ◽  
Yujun Chen ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Intestinal Inflammation ◽  
Portulaca Oleracea

scholarly journals Endoplasmic reticulum stress and intestinal inflammation

2009 ◽  
Vol 3 (1) ◽  
pp. 11-16 ◽  
Author(s):  
A Kaser ◽  
R S Blumberg
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Intestinal Inflammation

scholarly journals The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress–Driven Mucus Depletion and Exacerbates Intestinal Inflammation

2019 ◽  
Vol 7 (2) ◽  
pp. 457-473 ◽  
Author(s):  
Federica Laudisi ◽  
Davide Di Fusco ◽  
Vincenzo Dinallo ◽  
Carmine Stolfi ◽  
Antonio Di Grazia ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Intestinal Inflammation ◽  
Food Additive

scholarly journals Crosstalk Between Nuclear Glucose-Regulated Protein 78 and Tumor Protein 53 Contributes to the Lipopolysaccharide Aggravated Apoptosis of Endoplasmic Reticulum Stress-Responsive Porcine Intestinal Epithelial Cells

2018 ◽  
Vol 48 (6) ◽  
pp. 2441-2455 ◽  
Author(s):  
Qian Jiang ◽  
Gang Liu ◽  
Jiashun Chen ◽  
Kang Yao ◽  
Yulong Yin
Keyword(s):  
Endoplasmic Reticulum ◽  
Epithelial Cells ◽  
Endoplasmic Reticulum Stress ◽  
Intestinal Inflammation ◽  
Intestinal Epithelial Cells ◽  
Intestinal Cells ◽  
Intestinal Epithelial ◽  
Gram Negative ◽  
Rna Transfection ◽  
Glucose Regulated Protein

Background/Aims: Lipopolysaccharides (LPSs) act as virulence factors that trigger intestinal inflammation and thereby compromise the production of pigs worldwide. Intestinal diseases and dysfunction have been attributed to endoplasmic reticulum stress (ERS) and the subsequent apoptosis of intestinal epithelial cells. Therefore It is important to explore whether LPSs aggravate ERS-mediated apoptosis of intestinal epithelial cells. Methods: ERS and inflammation models were established in porcine cell line J2 (IPEC-J2) and the cells were treated with tunicamycin or LPS at specific times. The expression of marker proteins was determined by western blot and immunofluorescence. Possible crosstalk between proteins was analyzed by co-immunoprecipitation. Small interfering RNA transfection was employed to verify the mechanisms. Results: We found that Escherichia coli-derived LPS aggravated ERS and ERS-mediated apoptosis in ERS-responsive IPEC-J2 cells. The crosstalk between nuclear glucose-regulated protein 78 (GRP78) and tumor protein 53 (p53) was verified to trigger this LPS-aggravated apoptosis of ERS-responsive intestinal cells. Conclusion: This novel finding implies that intestinal malfunctions might solely originate from the effects of Gram-negative bacteria on ERS-responsive intestinal cells. The regulation of ERS signaling (especially the crosstalk between nuclear GRP78 and p53) in ERS-responsive/rapidly growing intestines may help intestinal cells survive from Gram-negative bacterial infections.

Lactobacillus acidophilus suppresses intestinal inflammation by inhibiting endoplasmic reticulum stress

2018 ◽  
Vol 34 (1) ◽  
pp. 178-185 ◽  
Author(s):  
Da Hye Kim ◽  
Soochan Kim ◽  
Jin Ha Lee ◽  
Jae Hyeon Kim ◽  
Xiumei Che ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Lactobacillus Acidophilus ◽  
Intestinal Inflammation

Abstract #403: The Glutathione Mimic Ebselen Inhibits Oxidative Stress but not Endoplasmic Reticulum Stress in Endothelial Cells.

2015 ◽  
Vol 21 ◽  
pp. 85-86
Author(s):  
William Kurban ◽  
Salma Makhoul Ahwach ◽  
Melanie Thomas ◽  
Luisa Onsteed-Haas ◽  
Michael Haas
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress

Abstract #402: Beta Blockers Suppress Dextrose-Induced Endoplasmic Reticulum Stress, Oxidative Stress and Apoptosis in Human Coronary Artery Endothelial Cells.

2015 ◽  
Vol 21 ◽  
pp. 85
Author(s):  
Harshit Shah ◽  
William Kurban ◽  
Luisa Onstead-Haas ◽  
Michael Haas ◽  
Arshag Mooradian
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Endoplasmic Reticulum ◽  
Coronary Artery ◽  
Endoplasmic Reticulum Stress ◽  
Beta Blockers ◽  
Human Coronary Artery ◽  
Stress Oxidative
Sign in / Sign up

Export Citation Format

Share Document