Multipath scattering simulation and SAR analysis for a composite model

In search of genetic markers of myocardial infarction (MI) risk, which have prognostic significance for Russians, we performed a replication study of MI association with genetic variants of PCSK9 (rs562556), APOE (epsilon polymorphism, rs7412 and rs429358), LPL (rs320), MTHFR (rs1801133), eNOS (rs2070744), and the 9p21 region (rs1333049) in 405 patients with MI and 198 controls. Significant MI association was observed with variants of the lipid metabolism genes (PCSK9, APOE and LPL), and of eNOS. The SNPs in the MTHFR gene and the 9p21 region were not significantly associated with MI one by one but were included in several different MI-associated allelic combinations identified by multilocus analysis. Since we have not revealed nonlinear epistatic interactions between the components of the identified combinations, we postulate that the cumulative effect of genes that form a combination arises from the summation of their small independent contributions. The prognostic significance of the additive composite model built from the PCSK9, APOE, LPL, and eNOS genes as genetic markers was assessed using ROC analysis. After we included these markers in the previously published composite model of individual genetic risk of MI, the prognostic efficacy in our sample reached AUC = 0.676. However, the results obtained in this study certainly need to be replicated in an independent sample of Russians.

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A Reinvestigation of the Deceptively Simple Reaction of Toluene with ●OH, and the Fate of the Benzyl Radical. I. a Combined Thermodynamic and Kinetic Study on the Competition Between ●OH Addition and Hydrogen Abstraction Reactions.

10.26434/chemrxiv.8281283.v1 ◽

2019 ◽

Author(s):

Zoi Salta ◽

Agnie M. Kosmas ◽

Marc E. Segovia ◽

Martina Kieninger ◽

Oscar Ventura ◽

...

Keyword(s):

Density Functional ◽

Room Temperature ◽

Hydrogen Abstraction ◽

Reaction Rates ◽

Composite Model ◽

Alternative Mechanism ◽

Radical Intermediate ◽

Experimental Conditions ◽

Methyl Group ◽

Benzyl Radical

This work reports density functional and composite model chemistry calculations performed on the reactions of toluene with the hydroxyl radical. Both experimentally observed H-abstraction from the methyl group and possible additions to the phenyl ring were investigated. Reaction enthalpies and heights of the barriers suggest that H-abstraction is more favorable than ●OH addition to the ring. The calculated reaction rates at room temperature and the radical-intermediate product fractions support this view. This is somehow contradictory with the fact that, under most experimental conditions, cresols are observed in a larger concentration than benzaldehyde. Since the accepted mechanism for benzaldehyde formation involves H-abstraction, a contradiction arises that begs for an explanation. In this first part of our work we give the evidences that support the preference of hydrogen abstraction over ●OH addition and suggest an alternative mechanism which shows that cresols can actually arise also from the former reaction and not only from the latter.

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A Reinvestigation of the Deceptively Simple Reaction of Toluene with ●OH, and the Fate of the Benzyl Radical. I. a Combined Thermodynamic and Kinetic Study on the Competition Between ●OH Addition and Hydrogen Abstraction Reactions.

10.26434/chemrxiv.8281283 ◽

2019 ◽

Author(s):

Zoi Salta ◽

Agnie M. Kosmas ◽

Marc E. Segovia ◽

Martina Kieninger ◽

Oscar Ventura ◽

...

Keyword(s):

Density Functional ◽

Room Temperature ◽

Hydrogen Abstraction ◽

Reaction Rates ◽

Composite Model ◽

Alternative Mechanism ◽

Radical Intermediate ◽

Experimental Conditions ◽

Methyl Group ◽

Benzyl Radical

This work reports density functional and composite model chemistry calculations performed on the reactions of toluene with the hydroxyl radical. Both experimentally observed H-abstraction from the methyl group and possible additions to the phenyl ring were investigated. Reaction enthalpies and heights of the barriers suggest that H-abstraction is more favorable than ●OH addition to the ring. The calculated reaction rates at room temperature and the radical-intermediate product fractions support this view. This is somehow contradictory with the fact that, under most experimental conditions, cresols are observed in a larger concentration than benzaldehyde. Since the accepted mechanism for benzaldehyde formation involves H-abstraction, a contradiction arises that begs for an explanation. In this first part of our work we give the evidences that support the preference of hydrogen abstraction over ●OH addition and suggest an alternative mechanism which shows that cresols can actually arise also from the former reaction and not only from the latter.

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Implications of linear relationships between local and macroscopic flow stresses in the composite model

Zeitschrift für Metallkunde ◽

10.3139/146.101276 ◽

2006 ◽

Vol 97 (5) ◽

pp. 594-596

Author(s):

Hael Mughrabi

Keyword(s):

Composite Model ◽

Linear Relationships

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Four-Higgs-doublet scheme in composite model for leptons, quarks and Higgs mesons

Lettere al Nuovo Cimento ◽

10.1007/bf02746707 ◽

1985 ◽

Vol 44 (6) ◽

pp. 417-420 ◽

Cited By ~ 1

Author(s):

T. Kobayashi

Keyword(s):

Higgs Doublet ◽

Composite Model

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SAR Analysis of Jute Substrate based Tri-bandAntenna for Wearable Applications

Journal of Physics Conference Series ◽

10.1088/1742-6596/1804/1/012203 ◽

2021 ◽

Vol 1804 (1) ◽

pp. 012203

Author(s):

D Ram Sandeep ◽

N Prabakaran ◽

B T P Madhav ◽

D Lokesh Reddy ◽

K Divya Sree ◽

...

Keyword(s):

Sar Analysis

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COLOR SUPERCONDUCTIVITY FROM SUPERSYMMETRY

Modern Physics Letters A ◽

10.1142/s021773230501786x ◽

2005 ◽

Vol 20 (20) ◽

pp. 1495-1502 ◽

Cited By ~ 2

Author(s):

NOBUHITO MARU ◽

MOTOI TACHIBANA

Keyword(s):

Chemical Potential ◽

Critical Value ◽

Composite Model ◽

Color Superconductivity

A supersymmetric composite model of color superconductivity is proposed. Quarks and diquarks are dynamically generated as composite fields by a newly introduced strong gauge dynamics. It is shown that the condensation of the scalar component of the diquark supermultiplet occurs when the chemical potential becomes larger than some critical value. We believe that the model captures well the aspects of the diquark condensate behavior and helps in understanding the diquark dynamics in real QCD. The results obtained here might be useful when we consider a theory composed of quarks and diquarks.

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