Regulation of NGFI-B/Nur77 gene expression in the rat ovary and in leydig tumor cells MA-10

2008 ◽  
Vol 75 (5) ◽  
pp. 931-939 ◽  
Author(s):  
Yoshihiko Inaoka ◽  
Takashi Yazawa ◽  
Miki Uesaka ◽  
Tetsuya Mizutani ◽  
Kazuya Yamada ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tumor Cells ◽  
Leydig Tumor Cells ◽  
Rat Ovary

scholarly journals Interaction between arachidonic acid and cAMP signaling pathways enhances steroidogenesis and StAR gene expression in MA-10 Leydig tumor cells

2002 ◽  
Vol 188 (1-2) ◽  
pp. 55-63 ◽  
Author(s):  
Xing Jia Wang ◽  
Matthew T. Dyson ◽  
Carolina Mondillo ◽  
Zoraida Patrignani ◽  
Omar Pignataro ◽  
...  
Keyword(s):  
Gene Expression ◽  
Arachidonic Acid ◽  
Signaling Pathways ◽  
Tumor Cells ◽  
Camp Signaling ◽  
Leydig Tumor Cells ◽  
Star Gene

scholarly journals Leveraging epigenetics to enhance the efficacy of immunotherapy

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Jonathan D. Licht ◽  
Richard L. Bennett
Keyword(s):  
Gene Expression ◽  
Clinical Trials ◽  
Antigen Presentation ◽  
Tumor Cells ◽  
Immune Evasion ◽  
Regulatory Elements ◽  
Chromatin Accessibility ◽  
Epigenetic Modifications ◽  
Main Body ◽  
Epigenetic Mechanisms

Abstract Background Epigenetic mechanisms regulate chromatin accessibility patterns that govern interaction of transcription machinery with genes and their cis-regulatory elements. Mutations that affect epigenetic mechanisms are common in cancer. Because epigenetic modifications are reversible many anticancer strategies targeting these mechanisms are currently under development and in clinical trials. Main body Here we review evidence suggesting that epigenetic therapeutics can deactivate immunosuppressive gene expression or reprogram tumor cells to activate antigen presentation mechanisms. In addition, the dysregulation of epigenetic mechanisms commonly observed in cancer may alter the immunogenicity of tumor cells and effectiveness of immunotherapies. Conclusions Therapeutics targeting epigenetic mechanisms may be helpful to counter immune evasion and improve the effectiveness of immunotherapies.

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