In vivo EPR extracellular pH-metry in tumors using a triphosphonated trityl radical

2016 ◽  
Vol 77 (6) ◽  
pp. 2438-2443 ◽  
Author(s):  
Valérie Marchand ◽  
Philippe Levêque ◽  
Benoit Driesschaert ◽  
Jacqueline Marchand-Brynaert ◽  
Bernard Gallez
Keyword(s):  
Extracellular Ph ◽  
In Vivo Epr ◽  
Trityl Radical ◽  
Ph Metry

scholarly journals In vivo imaging of extracellular pH using1H MRSI

1999 ◽  
Vol 41 (4) ◽  
pp. 743-750 ◽  
Author(s):  
Robert van Sluis ◽  
Zaver M. Bhujwalla ◽  
Natarajan Raghunand ◽  
Paloma Ballesteros ◽  
Jos� Alvarez ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Extracellular Ph

Application of a Homebuilt Overhauser-enhanced MRI using in vivo EPR Spectrometer to Mice Redox Imaging

2010 ◽  
Vol 49 ◽  
pp. S185
Author(s):  
Fuminori Hyodo ◽  
Tatsuya Naganuma ◽  
Kazuhiro Ichikawa ◽  
Suguru Sato ◽  
Hideo Utsumi
Keyword(s):  
Enhanced Mri ◽  
In Vivo Epr

Increased tumour extracellular pH induced by Bafilomycin A1 inhibits tumour growth and mitosis in vivo and alters 5-fluorouracil pharmacokinetics

2003 ◽  
Vol 39 (4) ◽  
pp. 532-540 ◽  
Author(s):  
P.M.J. McSheehy ◽  
H. Troy ◽  
L.R. Kelland ◽  
I.R. Judson ◽  
M.O. Leach ◽  
...  
Keyword(s):  
Tumour Growth ◽  
Extracellular Ph ◽  
Bafilomycin A1

Time course of exchanges between red cells and extracellular fluid during CO2 uptake

1975 ◽  
Vol 38 (4) ◽  
pp. 710-718 ◽  
Author(s):  
R. E. Forster ◽  
E. D. Crandall
Keyword(s):  
Carbonic Anhydrase ◽  
Time Course ◽  
Extracellular Fluid ◽  
Extracellular Ph ◽  
Co2 Uptake ◽  
Sudden Increase ◽  
Red Cell ◽  
Ph Change ◽  
Red Cell Membrane

A stopped-flow rapid-reaction apparatus was used to follow the time course of extracellular pH in a human red cell suspension following a sudden increase in PCO2. The extracellular pH change was slow (t1/2 similar to 3.5 s) considering the presence of carbonic anhydrase in the cells. When carbonic anhydrase was added to the extracellular fluid, the half-time was reduced to less than 20 ms. The explanation for these phenomena is that the equilibration of H+ across the red cell membrane is rate-limited by the uncatalyzed reaction CO2 plus H2O formed from H2CO3 outside the cells. A theoretical model was developed which successfully reproduced the experimental results. When the model was used to simulate CO2 exchange in vivo, it was determined that blood PCO2 and pH require long times (greater than 50 s) to approach equilibrium between cells and plasma after leaving an exchange capillary. We conclude that cell-plasma equilibrium may never be reached in vivo, and that in vitro measurements of these quantities may not represent their true values at the site of sampling.

scholarly journals In vivo EPR spectroscopic imaging for a liposomal drug delivery system

2005 ◽  
Vol 53 (5) ◽  
pp. 1158-1165 ◽  
Author(s):  
Ken-ichiro Matsumoto ◽  
Tomoaki Yahiro ◽  
Ken-ichi Yamada ◽  
Hideo Utsumi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Spectroscopic Imaging ◽  
Liposomal Drug ◽  
In Vivo Epr ◽  
Liposomal Drug Delivery

In vivo EPR spectroscopy

1995 ◽  
pp. 285-299 ◽  
Author(s):  
H. M. Swartz ◽  
G. Bacic ◽  
B. Gallez ◽  
F. Goda ◽  
P. James ◽  
...  
Keyword(s):  
Epr Spectroscopy ◽  
In Vivo Epr

Applications of In Vivo EPR

2018 ◽  
pp. 291-305
Author(s):  
Lawrence J. Berliner
Keyword(s):  
In Vivo Epr

scholarly journals In vivo EPR measurement of glutathione in tumor-bearing mice using improved disulfide biradical probe

2008 ◽  
Vol 45 (3) ◽  
pp. 312-320 ◽  
Author(s):  
Galina I. Roshchupkina ◽  
Andrey A. Bobko ◽  
Anna Bratasz ◽  
Vladimir A. Reznikov ◽  
Periannan Kuppusamy ◽  
...  
Keyword(s):  
Tumor Bearing ◽  
In Vivo Epr
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