Single‐ and multiple‐dose safety, tolerability, pharmacokinetic, and pharmacodynamic profiles of ASP0367 , or bocidelpar sulfate, a novel modulator of peroxisome proliferator‐activated receptor delta in healthy adults: Results from a phase 1 study

Muscle & Nerve ◽

10.1002/mus.27436 ◽

2021 ◽

Author(s):

Mototsugu Ito ◽

Sitra Tauscher‐Wisniewski ◽

Ronald A. Smulders ◽

Tomasz Wojtkowski ◽

Akihiro Yamada ◽

...

Keyword(s):

Multiple Dose ◽

Phase 1 ◽

Healthy Adults ◽

Peroxisome Proliferator ◽

Phase 1 Study ◽

Peroxisome Proliferator Activated Receptor

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Phase 1 study of efatutazone, a novel oral peroxisome proliferator-activated receptor gamma agonist, in combination with FOLFIRI as second-line therapy in patients with metastatic colorectal cancer

Investigational New Drugs ◽

10.1007/s10637-013-0056-3 ◽

2013 ◽

Vol 32 (3) ◽

pp. 473-480 ◽

Cited By ~ 13

Author(s):

Yoshito Komatsu ◽

Takayuki Yoshino ◽

Kentaro Yamazaki ◽

Satoshi Yuki ◽

Nozomu Machida ◽

...

Keyword(s):

Colorectal Cancer ◽

Metastatic Colorectal Cancer ◽

Phase 1 ◽

Peroxisome Proliferator ◽

Second Line ◽

Second Line Therapy ◽

Phase 1 Study ◽

Peroxisome Proliferator Activated Receptor ◽

Line Therapy

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A phase 1 study of efatutazone, an oral peroxisome proliferator-activated receptor gamma agonist, administered to patients with advanced malignancies

Cancer ◽

10.1002/cncr.27526 ◽

2012 ◽

Vol 118 (21) ◽

pp. 5403-5413 ◽

Cited By ~ 38

Author(s):

Michael J. Pishvaian ◽

John L. Marshall ◽

Andrew J. Wagner ◽

Jimmy J. Hwang ◽

Shakun Malik ◽

...

Keyword(s):

Phase 1 ◽

Peroxisome Proliferator ◽

Phase 1 Study ◽

Peroxisome Proliferator Activated Receptor ◽

Advanced Malignancies

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A Phase 1 Study of KHK4083: A Single‐Blind, Randomized, Placebo‐Controlled Single‐Ascending‐Dose Study in Healthy Adults and an Open‐Label Multiple‐Dose Study in Patients With Ulcerative Colitis

Clinical Pharmacology in Drug Development ◽

10.1002/cpdd.918 ◽

2021 ◽

Author(s):

Kenichi Furihata ◽

Yoh Ishiguro ◽

Naoki Yoshimura ◽

Hiroaki Ito ◽

Shinji Katsushima ◽

...

Keyword(s):

Ulcerative Colitis ◽

Multiple Dose ◽

Phase 1 ◽

Healthy Adults ◽

Open Label ◽

Phase 1 Study ◽

Multiple Dose Study ◽

Dose Study ◽

Single Blind ◽

Single Ascending Dose Study

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Faculty Opinions recommendation of Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a first-in-human, randomised, controlled, phase 1 study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737330759.793588335 ◽

2021 ◽

Author(s):

Alexander Freiberg

Keyword(s):

Monoclonal Antibody ◽

Phase 1 ◽

Human Monoclonal Antibody ◽

Healthy Adults ◽

Phase 1 Study ◽

Antibody Targeting ◽

Randomised Controlled

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Safety, pharmacokinetics, and immunogenicity of a co-formulated cocktail of three human monoclonal antibodies targeting Ebola virus glycoprotein in healthy adults: a randomised, first-in-human phase 1 study

The Lancet Infectious Diseases ◽

10.1016/s1473-3099(18)30397-9 ◽

2018 ◽

Vol 18 (8) ◽

pp. 884-893 ◽

Cited By ~ 42

Author(s):

Sumathi Sivapalasingam ◽

Mohamed Kamal ◽

Rabih Slim ◽

Romana Hosain ◽

Weiping Shao ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Ebola Virus ◽

Phase 1 ◽

Healthy Adults ◽

Human Monoclonal Antibodies ◽

Phase 1 Study ◽

Virus Glycoprotein

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Abstract 2899: Multiple-dose phase 1 study of 3,3′-diindolylmethane (DIM): Pharmacokinetics and biological effects

10.1158/1538-7445.am10-2899 ◽

2010 ◽

Author(s):

Gregory A. Reed ◽

Jean M. Sunega ◽

Kevin Latinis ◽

John Gray ◽

James A. Crowell ◽

...

Keyword(s):

Multiple Dose ◽

Biological Effects ◽

Phase 1 ◽

Phase 1 Study

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SP428A RANDOMIZED, SINGLE-CENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTIPLE-DOSE, PHASE 1 STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS (PK), AND PHARMACODYNAMICS (PD) OF TAK-272 IN HEALTHY ADULT NON-ELDERLY AND ELDERLY MALE SUBJECTS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfx149.sp428 ◽

2017 ◽

Vol 32 (suppl_3) ◽

pp. iii265-iii266 ◽

Cited By ~ 3

Author(s):

K Matsuno ◽

S Tanaka ◽

T Hashimoto ◽

H Nakamichi ◽

E Komura

Keyword(s):

Multiple Dose ◽

Healthy Adult ◽

Phase 1 ◽

Single Center ◽

Elderly Male ◽

Phase 1 Study ◽

Double Blind ◽

Double Blind Placebo ◽

Male Subjects

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Ascending Single/Multiple-Dose Phase 1 Study With KIN-1901 in Healthy Subjects and Subjects With Ankylosing Spondylitis

Case Medical Research ◽

10.31525/ct1-nct04205851 ◽

2019 ◽

Author(s):

Keyword(s):

Ankylosing Spondylitis ◽

Healthy Subjects ◽

Multiple Dose ◽

Phase 1 ◽

Phase 1 Study

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Safety, tolerability and pharmacodynamics of AZP-3601, a novel long-acting PTH analog, in healthy adults: Data from a randomized, double-blind, placebo-controlled phase 1 study

Endocrine Abstracts ◽

10.1530/endoabs.73.oc6.5 ◽

2021 ◽

Author(s):

Soraya Allas ◽

Michel Ovize ◽

Michael D. Culler ◽

Clarisse Geraul ◽

van de Wetering Jeroen ◽

...

Keyword(s):

Phase 1 ◽

Healthy Adults ◽

Phase 1 Study ◽

Double Blind ◽

Double Blind Placebo ◽

Long Acting

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A randomised, double-blind, placebo-controlled phase 1 study of the safety, tolerability and pharmacodynamics of volixibat in overweight and obese but otherwise healthy adults: implications for treatment of non-alcoholic steatohepatitis

BMC Pharmacology and Toxicology ◽

10.1186/s40360-018-0200-y ◽

2018 ◽

Vol 19 (1) ◽

Cited By ~ 13

Author(s):

Melissa Palmer ◽

Lee Jennings ◽

Debra G. Silberg ◽

Caleb Bliss ◽

Patrick Martin

Keyword(s):

Phase 1 ◽

Healthy Adults ◽

Phase 1 Study ◽

Double Blind ◽

Double Blind Placebo ◽

Alcoholic Steatohepatitis

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