High‐resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA‐tetraglycinate agents

2021 ◽  
Author(s):  
Jelena M. Mihailovic ◽  
Yuegao Huang ◽  
John J. Walsh ◽  
Muhammad H. Khan ◽  
Sandeep K. Mishra ◽  
...  
Keyword(s):  
High Resolution ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Ph Imaging

scholarly journals Method for high-resolution imaging of creatine in vivo using chemical exchange saturation transfer

2013 ◽  
Vol 71 (1) ◽  
pp. 164-172 ◽  
Author(s):  
Feliks Kogan ◽  
Mohammad Haris ◽  
Anup Singh ◽  
Kejia Cai ◽  
Catherine Debrosse ◽  
...  
Keyword(s):  
High Resolution ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
High Resolution Imaging ◽  
Saturation Transfer ◽  
Resolution Imaging

scholarly journals Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI: Basic Concept

2021 ◽  
pp. 241-256
Author(s):  
Dario Livio Longo ◽  
Pietro Irrera ◽  
Lorena Consolino ◽  
Phillip Zhe Sun ◽  
Michael T. McMahon
Keyword(s):  
Chemical Exchange ◽  
Kidney Diseases ◽  
Chemical Exchange Saturation Transfer ◽  
Functional Information ◽  
Saturation Transfer ◽  
Ph Changes ◽  
Ph Imaging ◽  
Cest Mri ◽  
Magnetic Resonance Imaging Mri ◽  
Renal Mri

AbstractMagnetic Resonance Imaging (MRI) has been actively explored in the last several decades for assessing renal function by providing several physiological information, including glomerular filtration rate, renal plasma flow, tissue oxygenation and water diffusion. Within MRI, the developing field of chemical exchange saturation transfer (CEST) has potential to provide further functional information for diagnosing kidney diseases. Both endogenous produced molecules as well as exogenously administered CEST agents have been exploited for providing functional information related to kidney diseases in preclinical studies. In particular, CEST MRI has been exploited for assessing the acid-base homeostasis in the kidney and for monitoring pH changes in several disease models. This review summarizes several CEST MRI procedures for assessing kidney functionality and pH, for monitoring renal pH changes in different kidney injury models and for evaluating renal allograft rejection.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.

scholarly journals Quantitative description of radiofrequency (RF) power-based ratiometric chemical exchange saturation transfer (CEST) pH imaging

2015 ◽  
Vol 28 (5) ◽  
pp. 555-565 ◽  
Author(s):  
Renhua Wu ◽  
Dario Livio Longo ◽  
Silvio Aime ◽  
Phillip Zhe Sun
Keyword(s):  
Chemical Exchange ◽  
Quantitative Description ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Rf Power ◽  
Ph Imaging

scholarly journals Analysis Protocol for the Quantification of Renal pH Using Chemical Exchange Saturation Transfer (CEST) MRI

2021 ◽  
pp. 667-688
Author(s):  
Hahnsung Kim ◽  
Yin Wu ◽  
Daisy Villano ◽  
Dario Livio Longo ◽  
Michael T. McMahon ◽  
...  
Keyword(s):  
Chemical Exchange ◽  
Kidney Injury ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Ph Imaging ◽  
Iodinated Contrast ◽  
Cest Mri ◽  
Renal Mri ◽  
Analysis Protocol

AbstractThe kidney plays a major role in maintaining body pH homeostasis. Renal pH, in particular, changes immediately following injuries such as intoxication and ischemia, making pH an early biomarker for kidney injury before the symptom onset and complementary to well-established laboratory tests. Because of this, it is imperative to develop minimally invasive renal pH imaging exams and test pH as a new diagnostic biomarker in animal models of kidney injury before clinical translation. Briefly, iodinated contrast agents approved by the US Food and Drug Administration (FDA) for computed tomography (CT) have demonstrated promise as novel chemical exchange saturation transfer (CEST) MRI agents for pH-sensitive imaging. The generalized ratiometric iopamidol CEST MRI analysis enables concentration-independent pH measurement, which simplifies in vivo renal pH mapping. This chapter describes quantitative CEST MRI analysis for preclinical renal pH mapping, and their application in rodents, including normal conditions and acute kidney injury.This publication is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This analysis protocol chapter is complemented by two separate chapters describing the basic concepts and experimental procedure.

High‐resolution creatine mapping of mouse brain at 11.7 T using non‐steady‐state chemical exchange saturation transfer

2019 ◽  
Vol 32 (11) ◽  
Author(s):  
Lin Chen ◽  
Zhiliang Wei ◽  
Shuhui Cai ◽  
Yuguo Li ◽  
Guanshu Liu ◽  
...  
Keyword(s):  
Steady State ◽  
High Resolution ◽  
Mouse Brain ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
State Chemical

pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI

2017 ◽  
Vol 57 (9) ◽  
pp. 862-879 ◽  
Author(s):  
KowsalyaDevi Pavuluri ◽  
Michael T. McMahon
Keyword(s):  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Ph Imaging ◽  
Cest Mri

scholarly journals Tissue Characterization with Quantitative High-Resolution Magic Angle Spinning Chemical Exchange Saturation Transfer Z-Spectroscopy

2016 ◽  
Vol 88 (21) ◽  
pp. 10379-10383 ◽  
Author(s):  
Iris Yuwen Zhou ◽  
Taylor L. Fuss ◽  
Takahiro Igarashi ◽  
Weiping Jiang ◽  
Xin Zhou ◽  
...  
Keyword(s):  
High Resolution ◽  
Tissue Characterization ◽  
Chemical Exchange ◽  
Magic Angle Spinning ◽  
Chemical Exchange Saturation Transfer ◽  
Magic Angle ◽  
Saturation Transfer ◽  
Angle Spinning
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