Subunit-dependent cadmium and nickel inhibition of acid-sensing ion channels

2007 ◽  
Vol 67 (1) ◽  
pp. 97-107 ◽  
Author(s):  
Alexander Staruschenko ◽  
Natalia A. Dorofeeva ◽  
Konstantin V. Bolshakov ◽  
James D. Stockand
Keyword(s):  
Ion Channels ◽  
Acid Sensing Ion Channels

Acid-sensing ion channels

2006 ◽  
pp. S100-S101
Author(s):  
S P H Alexander ◽  
A Mathie ◽  
J A Peters
Keyword(s):  
Ion Channels ◽  
Acid Sensing Ion Channels

Acid Sensing Ion Channels (ASICs) und 5-HT-Rezeptoren bei GERD. Untersuchungen zur Genexpression im pharmakologischen Modell

2015 ◽  
Vol 53 (08) ◽  
Author(s):  
A Shcherbokova ◽  
H Abdel-Aziz ◽  
O Kelber ◽  
K Nieber ◽  
G Ulrich-Merzenich
Keyword(s):  
Ion Channels ◽  
Acid Sensing Ion Channels

Acid-Sensing Ion Channels

2020 ◽  
Author(s):  
Stefan Gründer
Keyword(s):  
Nervous System ◽  
Ion Channels ◽  
Excitatory Synapses ◽  
Detailed Characterization ◽  
High Affinity ◽  
Acid Sensing Ion Channels ◽  
Long Time ◽  
Pathological Pain

Acid-sensing ion channels (ASICs) are proton-gated Na+ channels. Being almost ubiquitously present in neurons of the vertebrate nervous system, their precise function remained obscure for a long time. Various animal toxins that bind to ASICs with high affinity and specificity have been tremendously helpful in uncovering the role of ASICs. We now know that they contribute to synaptic transmission at excitatory synapses as well as to sensing metabolic acidosis and nociception. Moreover, detailed characterization of mouse models uncovered an unanticipated role of ASICs in disorders of the nervous system like stroke, multiple sclerosis, and pathological pain. This review provides an overview on the expression, structure, and pharmacology of ASICs plus a summary of what is known and what is still unknown about their physiological functions and their roles in diseases.

scholarly journals Acid sensing ion channels regulate neuronal excitability by inhibiting BK potassium channels

2012 ◽  
Vol 426 (4) ◽  
pp. 511-515 ◽  
Author(s):  
Elena Petroff ◽  
Vladislav Snitsarev ◽  
Huiyu Gong ◽  
Francois M. Abboud
Keyword(s):  
Ion Channels ◽  
Potassium Channels ◽  
Neuronal Excitability ◽  
Acid Sensing Ion Channels

scholarly journals The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na+channel (ENaC): IUPHAR Review 19

2016 ◽  
Vol 173 (18) ◽  
pp. 2671-2701 ◽  
Author(s):  
Emilie Boscardin ◽  
Omar Alijevic ◽  
Edith Hummler ◽  
Simona Frateschi ◽  
Stephan Kellenberger
Keyword(s):  
Ion Channels ◽  
Na Channel ◽  
Acid Sensing Ion Channels ◽  
Epithelial Na Channel

scholarly journals Basics on the use of acid-sensing ion channels’ inhibitors as therapeutics

2019 ◽  
Vol 14 (3) ◽  
pp. 395 ◽  
Author(s):  
Adnan Dibas ◽  
Jamileh Dibas ◽  
Houssam Al-Saad
Keyword(s):  
Ion Channels ◽  
Acid Sensing Ion Channels
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