scholarly journals Corrigendum: Blockade of Acid-Sensing Ion Channels Increases Urinary Bladder Capacity With or Without Intravesical Irritation in Mice

2020 ◽  
Vol 11 ◽  
Author(s):  
Mitsuharu Yoshiyama ◽  
Hideki Kobayashi ◽  
Masayuki Takeda ◽  
Isao Araki
Keyword(s):  
Ion Channels ◽  
Urinary Bladder ◽  
Bladder Capacity ◽  
Acid Sensing Ion Channels

scholarly journals Blockade of Acid-Sensing Ion Channels Increases Urinary Bladder Capacity With or Without Intravesical Irritation in Mice

2020 ◽  
Vol 11 ◽  
Author(s):  
Mitsuharu Yoshiyama ◽  
Hideki Kobayashi ◽  
Masayuki Takeda ◽  
Isao Araki
Keyword(s):  
Acetic Acid ◽  
Ion Channels ◽  
Urinary Bladder ◽  
Bladder Capacity ◽  
Saline Infusion ◽  
Acid Sensing Ion Channels ◽  
Vehicle Injection ◽  
The Central Nervous System ◽  
Bladder Activity

We conducted this study to examine whether acid-sensing ion channels (ASICs) are involved in the modulation of urinary bladder activity with or without intravesical irritation induced by acetic acid. All in vivo evaluations were conducted during continuous infusion cystometry in decerebrated unanesthetized female mice. During cystometry with a pH 6.3 saline infusion, an i.p. injection of 30 μmol/kg A-317567 (a potent, non-amiloride ASIC blocker) increased the intercontraction interval (ICI) by 30% (P < 0.001), whereas vehicle injection had no effect. An intravesical acetic acid (pH 3.0) infusion induced bladder hyperactivity, with reductions in ICI and maximal voiding pressure (MVP) by 79% (P < 0.0001) and 29% (P < 0.001), respectively. A-317567 (30 μmol/kg i.p.) alleviated hyperreflexia by increasing the acid-shortened ICI by 76% (P < 0.001). This dose produced no effect on MVP under either intravesical pH condition. Further analysis in comparison with vehicle showed that the increase in ICI (or bladder capacity) by the drug was not dependent on bladder compliance. Meanwhile, intravesical perfusion of A-317567 (100 μM) had no effect on bladder activity during pH 6.0 saline infusion cystometry, and drug perfusion at neither 100 μM nor 1 mM produced any effects on bladder hyperreflexia during pH 3.0 acetic acid infusion cystometry. A-317567 has been suggested to display extremely poor penetrability into the central nervous system and thus to be a peripherally active blocker. Taken together, our results suggest that blockade of ASIC signal transduction increases bladder capacity under normal intravesical pH conditions and alleviates bladder hyperreflexia induced by intravesical acidification and that the site responsible for this action is likely to be the dorsal root ganglia.

Sex differences in the expression profile of acid-sensing ion channels in the mouse urinary bladder: a possible involvement in irritative bladder symptoms

2009 ◽  
Vol 104 (11) ◽  
pp. 1746-1751 ◽  
Author(s):  
Hideki Kobayashi ◽  
Mitsuharu Yoshiyama ◽  
Hidenori Zakoji ◽  
Masayuki Takeda ◽  
Isao Araki
Keyword(s):  
Sex Differences ◽  
Ion Channels ◽  
Urinary Bladder ◽  
Expression Profile ◽  
Acid Sensing Ion Channels ◽  
Bladder Symptoms

Acid-sensing ion channels

2006 ◽  
pp. S100-S101
Author(s):  
S P H Alexander ◽  
A Mathie ◽  
J A Peters
Keyword(s):  
Ion Channels ◽  
Acid Sensing Ion Channels

Acid Sensing Ion Channels (ASICs) und 5-HT-Rezeptoren bei GERD. Untersuchungen zur Genexpression im pharmakologischen Modell

2015 ◽  
Vol 53 (08) ◽  
Author(s):  
A Shcherbokova ◽  
H Abdel-Aziz ◽  
O Kelber ◽  
K Nieber ◽  
G Ulrich-Merzenich
Keyword(s):  
Ion Channels ◽  
Acid Sensing Ion Channels

Acid-Sensing Ion Channels

2020 ◽  
Author(s):  
Stefan Gründer
Keyword(s):  
Nervous System ◽  
Ion Channels ◽  
Excitatory Synapses ◽  
Detailed Characterization ◽  
High Affinity ◽  
Acid Sensing Ion Channels ◽  
Long Time ◽  
Pathological Pain

Acid-sensing ion channels (ASICs) are proton-gated Na+ channels. Being almost ubiquitously present in neurons of the vertebrate nervous system, their precise function remained obscure for a long time. Various animal toxins that bind to ASICs with high affinity and specificity have been tremendously helpful in uncovering the role of ASICs. We now know that they contribute to synaptic transmission at excitatory synapses as well as to sensing metabolic acidosis and nociception. Moreover, detailed characterization of mouse models uncovered an unanticipated role of ASICs in disorders of the nervous system like stroke, multiple sclerosis, and pathological pain. This review provides an overview on the expression, structure, and pharmacology of ASICs plus a summary of what is known and what is still unknown about their physiological functions and their roles in diseases.

Radiologic Method to Assess Urinary Bladder Capacity and Proportions in Children

1984 ◽  
Vol 25 (1) ◽  
pp. 33-37 ◽  
Author(s):  
C. F. Engström ◽  
H. Ringertz
Keyword(s):  
Urinary Bladder ◽  
Bladder Capacity
Sign in / Sign up

Export Citation Format

Share Document