scholarly journals Intervening on exercise and daylong movement for weight loss maintenance in older adults: A randomized, clinical trial

Obesity ◽  
2021 ◽  
Vol 30 (1) ◽  
pp. 85-95
Author(s):  
Jason Fanning ◽  
W. Jack Rejeski ◽  
Iris Leng ◽  
Cheyenne Barnett ◽  
James F. Lovato ◽  
...  

Obesity ◽  
2015 ◽  
Vol 23 (10) ◽  
pp. 2015-2021 ◽  
Author(s):  
Adam G. Tsai ◽  
Sue Felton ◽  
Thomas A. Wadden ◽  
Patrick W. Hosokawa ◽  
James O. Hill


2018 ◽  
Vol 74 (10) ◽  
pp. 1598-1604 ◽  
Author(s):  
Melissa M Markofski ◽  
Kristofer Jennings ◽  
Kyle L Timmerman ◽  
Jared M Dickinson ◽  
Christopher S Fry ◽  
...  

Abstract Background Essential amino acids (EAA) and aerobic exercise (AE) acutely and independently stimulate skeletal muscle protein anabolism in older adults. Objective In this Phase 1, double-blind, placebo-controlled, randomized clinical trial, we determined if chronic EAA supplementation, AE training, or a combination of the two interventions could improve muscle mass and function by stimulating muscle protein synthesis. Methods We phone-screened 971, enrolled 109, and randomized 50 independent, low-active, nonfrail, and nondiabetic older adults (age 72 ± 1 years). We used a 2 × 2 factorial design. The interventions were: daily nutritional supplementation (15 g EAA or placebo) and physical activity (supervised AE training 3 days/week or monitored habitual activity) for 24 weeks. Muscle strength, physical function, body composition, and muscle protein synthesis were measured before and after the 24-week intervention. Results Forty-five subjects completed the 24-week intervention. VO2peak and walking speed increased (p < .05) in both AE groups, irrespective of supplementation type, but muscle strength increased only in the EAA + AE group (p < .05). EAA supplementation acutely increased (p < .05) muscle protein synthesis from basal both before and after the intervention, with a larger increase in the EAA + AE group after the intervention. Total and regional lean body mass did not change significantly with any intervention. Conclusions In nonfrail, independent, healthy older adults AE training increased walking speed and aerobic fitness, and, when combined with EAA supplementation, it also increased muscle strength and EAA-stimulated muscle protein synthesis. These increases occurred without improvements in muscle mass.



2016 ◽  
Vol 29 ◽  
pp. 1-8 ◽  
Author(s):  
Cynthia Vieira Sanches Sampaio ◽  
Manuela Garcia Lima ◽  
Ana Marice Ladeia


2021 ◽  
Vol 15 (3) ◽  
pp. 460-471
Author(s):  
Lingli Cai ◽  
Jun Yin ◽  
Xiaojing Ma ◽  
Yifei Mo ◽  
Cheng Li ◽  
...  


2020 ◽  
Vol 133 (7) ◽  
pp. 848-856.e5 ◽  
Author(s):  
Baris Gencer ◽  
Elisavet Moutzouri ◽  
Manuel R. Blum ◽  
Martin Feller ◽  
Tinh-Hai Collet ◽  
...  


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