Multi‐innovation gradient parameter estimation for multivariable systems based on the maximum likelihood principle

Author(s):  
Huafeng Xia ◽  
Sheng Xu ◽  
Cheng Zhou ◽  
Feiyan Chen
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Lisa Amrhein ◽  
Christiane Fuchs

Abstract Background Tissues are often heterogeneous in their single-cell molecular expression, and this can govern the regulation of cell fate. For the understanding of development and disease, it is important to quantify heterogeneity in a given tissue. Results We present the R package stochprofML which uses the maximum likelihood principle to parameterize heterogeneity from the cumulative expression of small random pools of cells. We evaluate the algorithm’s performance in simulation studies and present further application opportunities. Conclusion Stochastic profiling outweighs the necessary demixing of mixed samples with a saving in experimental cost and effort and less measurement error. It offers possibilities for parameterizing heterogeneity, estimating underlying pool compositions and detecting differences between cell populations between samples.


Open Physics ◽  
2009 ◽  
Vol 7 (3) ◽  
Author(s):  
Antonio Scarfone ◽  
Hiroki Suyari ◽  
Tatsuaki Wada

AbstractWe reformulate the Gauss’ law of error in presence of correlations which are taken into account by means of a deformed product arising in the framework of the Sharma-Taneja-Mittal measure. Having reviewed the main proprieties of the generalized product and its related algebra, we derive, according to the Maximum Likelihood Principle, a family of error distributions with an asymptotic power-law behavior.


2007 ◽  
Vol 61 (6) ◽  
Author(s):  
J. Balán ◽  
L. Morávková ◽  
J. Linek

AbstractThe densities of the (cyclohexane + pentane, or hexane, or heptane, or octane, or nonane) systems were measured at the temperature 298.15 K by means of a vibrating-tube densimeter. Their respective excess molar volumes were calculated and correlated using the fourth-order Redlich—Kister equation, with the maximum likelihood principle being applied in the determination of the adjustable parameters. The values of excess molar volumes were negative for the cyclohexane + pentane system, whereas they were positive for the other systems with the values increasing with the number of carbon atoms in the respective alkane molecules.


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