Signalling networks associated with urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in breast cancer tissues: new insights from protein microarray analysis

2010 ◽  
Vol 223 (1) ◽  
pp. 54-63 ◽  
Author(s):  
Claudia Wolff ◽  
Katharina Malinowsky ◽  
Daniela Berg ◽  
Kerstin Schragner ◽  
Tibor Schuster ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Plasminogen Activator ◽  
Microarray Analysis ◽  
Protein Microarray ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Protein Microarray Analysis ◽  
Cancer Tissues ◽  
Pai 1

Urokinase-type plasminogen activator: a potent marker of metastatic potential in human cancers

2002 ◽  
Vol 30 (2) ◽  
pp. 207-210 ◽  
Author(s):  
M. J. Duffy
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Plasminogen Activator ◽  
Prospective Trial ◽  
Axillary Node ◽  
Prognostic Impact ◽  
Breast Cancer Patients ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Pai 1

Urokinase-type plasminogen activator (uPA) is a serine protease that is causally involved in cancer progression, especially invasion and metastasis. Multiple studies have shown that breast cancer patients whose primary cancer contains high levels of uPA have a significantly worse outcome than patients with low levels. As a prognostic marker for breast cancer the information supplied by uPA is both independent of traditionally used factors and significant in the important subgroup of axillary-node patients. Paradoxically, high levels of plasminogen activator inhibitor-1 (PAI-1), an endogenous inhibitor of uPA, also predict for aggressive disease. Recently, the prognostic impact of both uPA and PAI-1 in axillary node-negative breast cancer was confirmed using two different Level 1 Evidence studies, i.e. in both a randomized prospective trial and a pooled analysis. Therefore, uPA and PAI-1 appear to have fulfilled all the criteria for the routine assessment of prognosis in newly diagnosed breast cancer patients

scholarly journals Assessment of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in Breast Cancer Tissue: Historical Aspects and Future Prospects

Breast Care ◽  
2008 ◽  
Vol 3 (2) ◽  
pp. 2-2 ◽  
Author(s):  
Manfred Schmitt ◽  
Karin Mengele ◽  
Apostolos Gkazepis ◽  
Rudolf Napieralski ◽  
Viktor Magdolen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Plasminogen Activator ◽  
Breast Cancer Tissue ◽  
Cancer Tissue ◽  
Future Prospects ◽  
Historical Aspects ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Pai 1
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