Comment on: “Premedication prior to PEG‐asparaginase is cost effective in pediatric patients with acute lymphoblastic leukemia”

2021 ◽  
Author(s):  
Wing H. Tong ◽  
Carin A. Uyl‐De Groot
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Pediatric Patients ◽  
Lymphoblastic Leukemia ◽  
Cost Effective

Premedication prior to PEG‐asparaginase is cost‐effective in pediatric patients with acute lymphoblastic leukemia

2021 ◽  
Author(s):  
Meghan McCormick ◽  
Jillian Lapinski ◽  
Erika Friehling ◽  
Kenneth Smith
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Pediatric Patients ◽  
Lymphoblastic Leukemia ◽  
Cost Effective

Gut bacterial gene changes following pegaspargase treatment in pediatric patients with acute lymphoblastic leukemia

2021 ◽  
pp. 1-12
Author(s):  
Katherine A. Dunn ◽  
Zara Forbrigger ◽  
Jessica Connors ◽  
Mushfiqur Rahman ◽  
Alejandro Cohen ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Pediatric Patients ◽  
Lymphoblastic Leukemia ◽  
Bacterial Gene

Screening for asymptomatic diabetes and metabolic comorbidities in pediatric patients during therapy for acute lymphoblastic leukemia

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Valerie Larouche ◽  
Caroline Bellavance ◽  
Pauline Tibout ◽  
Sebastien Bergeron ◽  
David Simonyan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Acute Lymphoblastic Leukemia ◽  
Pediatric Patients ◽  
Lymphoblastic Leukemia ◽  
Fasting Blood Glucose ◽  
Metabolic Disturbances ◽  
Metabolic Complications ◽  
Glucose Levels ◽  
Oncology Unit ◽  
Hba1c Levels

Abstract Objectives Chronic metabolic disturbances related to cancer treatment are well reported among survivors of pediatric acute lymphoblastic leukemia (ALL). However, few studies have investigated the incidence of these complications during the phase of chemotherapy. We evaluated the incidence of acute metabolic complications occurring during therapy in our cohort of patients diagnosed with ALL. Methods A prospective study involving 50 ALL pediatric patients diagnosed and treated between 2012 and 2016 in our oncology unit. We collected weight, blood pressure, fasting plasma glucose and hemoglobin A1C (HBA1c) levels during the two years of therapy. Results Obesity and overweight occurred in 43 and 25%, respectively among patients and have been reached at 12 months of chemotherapy. About 26% of the patients developed high blood pressure and 14% experienced hyperglycemias without meeting diabetes criteria. There was a significant decrease of HBA1c levels between the beginning and the end of therapy (p<0.0001). Conclusions Increase of body mass index in our ALL pediatric patients occurred during the first months of therapy and plateaued after a year of treatment. We should target this population for early obesity prevention. HbA1c levels measured during therapy did not reveal diabetes criteria. Hence, fasting blood glucose levels are sufficient to monitor ALL pediatric patients’ glycemia.

Poster: ALL-125: PHi-RACE: PGIMER In-House Rapid and Cost-Effective Classifier for the Rapid Detection of BCR-ABL1-Like Acute Lymphoblastic Leukemia in Indian Patients

2021 ◽  
Vol 21 ◽  
pp. S206
Author(s):  
Dikshat Gopal Gupta ◽  
Neelam Varma ◽  
Ashish Kumar ◽  
Shano Naseem ◽  
Man Updesh Singh Sachdeva ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Rapid Detection ◽  
Lymphoblastic Leukemia ◽  
Cost Effective ◽  
Indian Patients

scholarly journals Letter regarding Zhao et al. entitled “DPYD gene polymorphisms are associated with risk and chemotherapy prognosis in pediatric patients with acute lymphoblastic leukemia”

Tumor Biology ◽  
2017 ◽  
Vol 39 (6) ◽  
pp. 101042831770162
Author(s):  
Maarten J Deenen ◽  
Linda M Henricks ◽  
Gabe S Sonke ◽  
Jan HM Schellens ◽  
Didier Meulendijks
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Gene Polymorphisms ◽  
Pediatric Patients ◽  
Lymphoblastic Leukemia ◽  
Dpyd Gene

Native E. coli asparaginase upfront should be replaced by PEGasparaginase upfront in the treatment of pediatric patients with acute lymphoblastic leukemia

2021 ◽  
Author(s):  
Wing H. Tong ◽  
Montserrat Mesegué ◽  
José Luís Dapena ◽  
Mireia Camós ◽  
Susana Rives
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Pediatric Patients ◽  
Lymphoblastic Leukemia ◽  
E Coli

scholarly journals Obesity in pediatric patients with acute lymphoblastic leukemia increases the risk of adverse events during pre-maintenance chemotherapy

2018 ◽  
Vol 66 (2) ◽  
pp. e27515 ◽  
Author(s):  
Chelsea K. Meenan ◽  
John A. Kelly ◽  
Li Wang ◽  
A. Kim Ritchey ◽  
Scott H Maurer
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Adverse Events ◽  
Pediatric Patients ◽  
Lymphoblastic Leukemia ◽  
Maintenance Chemotherapy
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