Background:
Destroying hydrophobicity and increasing bioavailability of anticancer drugs
is emerging field in biomedical nanotherapy.
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Methods: The porous and oval shaped Gd2O3 gadolinite nanoparticles were synthesized and surface
functionalized with folate groups using wet coprecipitation method. The presence of spinal nanophase
with Gd2O3 lattice inside nanoparticles was confirmed by the use of XRD pattern and supportive FTIR
spectrum. XRD data of nanocomposites proved the spinal core of gadolinite phase even after surface
tailoring. These porous nanoparticles were loaded with anticancer drug 5-flurouracil for enhancement
of anticancer activity on breast cancer MCF-7 cells. The elemental, optical, morphological and phase
physicochemical characterization of the nanomaterials were performed using techniques such as PL,
FTIR, XRD spectrometry, TGA thermal analysis, SEM and TEM microscopic analysis. The photoactive
biocompatibility of nanohybrids was elaborated on gram positive S. aureus bacteria by agar well
antibacterial screening in dark and light.
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Results: The nanocomposites not only exhibited photoactive biocompatibility but also pH responsive in
vitro delivery applied for anticancer therapy on the basis of spectrometric assay following sustained release
with zero order Peppas release kinetics.
Conclusion:
The nanocomposites exhibited higher anticancer activity on MCF-7 cells than free drug
and nanohybrids after in vitro MTT assay. These 5-FU loaded folate targeted luminescent and photoactive
nanocomposites with gadolinite core find applications in the future biomedical cell-particle interface.
Characterization of pH-responsive hydrogels of poly(itaconic acid-g-ethylene glycol) prepared by UV-initiated free radical polymerization as biomaterials for oral delivery of bioactive agents