Platelet proteomics in thalassemia: Factors responsible for hypercoagulation

2015 ◽  
Vol 10 (3) ◽  
pp. 239-247 ◽  
Author(s):  
Shilpita Karmakar ◽  
Debasis Banerjee ◽  
Abhijit Chakrabarti
Keyword(s):  
Platelet Proteomics

scholarly journals Platelet proteomics

2003 ◽  
Vol 1 (7) ◽  
pp. 1593-1601 ◽  
Author(s):  
P. B. Maguire ◽  
D. J. Fitzgerald
Keyword(s):  
Platelet Proteomics

scholarly journals Platelets in Healthy and Disease States: From Biomarkers Discovery to Drug Targets Identification by Proteomics

2020 ◽  
Vol 21 (12) ◽  
pp. 4541 ◽  
Author(s):  
Erica Gianazza ◽  
Maura Brioschi ◽  
Roberta Baetta ◽  
Alice Mallia ◽  
Cristina Banfi ◽  
...  
Keyword(s):  
Drug Targets ◽  
Disease Diagnosis ◽  
Post Translational Modifications ◽  
Disease States ◽  
Recent Advances ◽  
Health And Disease ◽  
Proteome Changes ◽  
Platelet Proteomics ◽  
The Impact ◽  
Platelet Functions

Platelets are a heterogeneous small anucleate blood cell population with a central role both in physiological haemostasis and in pathological states, spanning from thrombosis to inflammation, and cancer. Recent advances in proteomic studies provided additional important information concerning the platelet biology and the response of platelets to several pathophysiological pathways. Platelets circulate systemically and can be easily isolated from human samples, making proteomic application very interesting for characterizing the complexity of platelet functions in health and disease as well as for identifying and quantifying potential platelet proteins as biomarkers and novel antiplatelet therapeutic targets. To date, the highly dynamic protein content of platelets has been studied in resting and activated platelets, and several subproteomes have been characterized including platelet-derived microparticles, platelet granules, platelet releasates, platelet membrane proteins, and specific platelet post-translational modifications. In this review, a critical overview is provided on principal platelet proteomic studies focused on platelet biology from signaling to granules content, platelet proteome changes in several diseases, and the impact of drugs on platelet functions. Moreover, recent advances in quantitative platelet proteomics are discussed, emphasizing the importance of targeted quantification methods for more precise, robust and accurate quantification of selected proteins, which might be used as biomarkers for disease diagnosis, prognosis and therapy, and their strong clinical impact in the near future.

Platelet Proteomics and its Applications to Study Platelet-Related Disorders

2017 ◽  
pp. 157-170
Author(s):  
Michela Di Michele ◽  
Kris Gevaert ◽  
Kathleen Freson
Keyword(s):  
Platelet Proteomics

scholarly journals Platelet Proteomics: Identification of Potential Therapeutic Targets

2003 ◽  
Vol 33 (5-6) ◽  
pp. 481-486 ◽  
Author(s):  
Patricia B. Maguire
Keyword(s):  
Therapeutic Targets ◽  
Platelet Proteomics

Platelet proteomics in diagnostic differentiation of primary immune thrombocytopenia using SELDI-TOF-MS

2016 ◽  
Vol 455 ◽  
pp. 75-79 ◽  
Author(s):  
Hong-Wei Zhang ◽  
Pan Zhou ◽  
Kai-Zheng Wang ◽  
Jin-Bo Liu ◽  
Yuan-Shuai Huang ◽  
...  
Keyword(s):  
Immune Thrombocytopenia ◽  
Primary Immune Thrombocytopenia ◽  
Platelet Proteomics ◽  
Tof Ms ◽  
Diagnostic Differentiation

Exploring the potential of platelet proteomics in children

2014 ◽  
Vol 8 (11-12) ◽  
pp. 807-812 ◽  
Author(s):  
Christina Yip ◽  
Ángel García
Keyword(s):  
Platelet Proteomics

scholarly journals Platelet Proteomics: Essentials for Understanding and Application

2006 ◽  
Vol 33 (3) ◽  
pp. 227-235 ◽  
Author(s):  
Jan Moebius ◽  
René-Peiman Zahedi ◽  
Albert Sickmann
Keyword(s):  
Platelet Proteomics
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