scholarly journals Dexamethasone promotes the endoplasmic reticulum stress response of bone marrow mesenchymal stem cells by activating the PERK‐Nrf2 signaling pathway

2021 ◽  
Vol 9 (3) ◽  
Author(s):  
Suoli Cheng ◽  
Xueqin Liu ◽  
Fan Gong ◽  
Xiaoling Ding ◽  
Xuebing Zhou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Endoplasmic Reticulum ◽  
Mesenchymal Stem Cells ◽  
Stress Response ◽  
Endoplasmic Reticulum Stress ◽  
Signaling Pathway ◽  
Endoplasmic Reticulum Stress Response ◽  
Nrf2 Signaling Pathway ◽  
Marrow Mesenchymal Stem Cells

Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells

2014 ◽  
Vol 31 (3) ◽  
pp. 314-328 ◽  
Author(s):  
Yih-An King ◽  
Yu-Jen Chiu ◽  
Hao-Ping Chen ◽  
Daih-Huang Kuo ◽  
Chi-Cheng Lu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Endoplasmic Reticulum ◽  
Mesenchymal Stem Cells ◽  
Endoplasmic Reticulum Stress ◽  
Arsenic Trioxide ◽  
Intrinsic Apoptosis ◽  
Marrow Mesenchymal Stem Cells

scholarly journals Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress through Regulation of CHOP and JNK in Bone Marrow Mesenchymal Stem Cells from Patients with Systemic Lupus Erythematosus

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Genkai Guo ◽  
Yan Meng ◽  
Wei Tan ◽  
Yunfei Xia ◽  
Chun Cheng ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Stem Cells ◽  
Bone Marrow ◽  
Endoplasmic Reticulum ◽  
Mesenchymal Stem Cells ◽  
Endoplasmic Reticulum Stress ◽  
Lupus Erythematosus ◽  
B Cell Lymphoma ◽  
Systemic Lupus ◽  
Marrow Mesenchymal Stem Cells

Previous studies indicated that bone marrow mesenchymal stem cells (BM-MSCs) from patients with systemic lupus erythematosus (SLE) exhibited the phenomenon of apoptosis. In this study, we aimed to investigate whether apoptosis of BM-MSCs from SLE patients were dysregulated. In this paper, endoplasmic reticulum stress (ERS) was evidenced by increased expression of phosphorylated protein kinase RNA-like ER kinase (PERK) and inositol-requiring protein-1 (IRE-1). We also found the activation of downstream target eukaryotic translation initiator factor 2α(eIF 2α) and CCAAT/enhancer-binding protein- (C/EBP-) homologous protein (CHOP) in BM-MSCs from SLE patients. Interestingly, we discovered that 4-phenylbutyric acid (4-PBA), a selective inhibitor of ERS, blocked the apoptosis of BM-MSCs from SLE patients and alleviated the level of Jun N-terminal kinase1/2 (JNK1/2) and CHOP. Furthermore, blockage of PERK signaling expression by siRNA not only significantly reduced the expression of CHOP, but also activated the anti-apoptotic regulator B-cell lymphoma-2 (Bcl-2). Blockage of IRE-1 or JNK1/2 by siRNA resulted in the decreased expression of JNK1/2 and proapoptosis protein Bcl-2 associated protein X (BAX). These results implicated that ERS-mediated apoptosis was a critical determinant of BM-MSCs from SLE patients.

SIRT6 Regulates Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells Partially via Suppressing the Nuclear Factor-κB Signaling Pathway

Stem Cells ◽  
2014 ◽  
Vol 32 (7) ◽  
pp. 1943-1955 ◽  
Author(s):  
Hualing Sun ◽  
Yanru Wu ◽  
Dongjie Fu ◽  
Yinchen Liu ◽  
Cui Huang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Signaling Pathway ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Marrow Mesenchymal Stem Cells ◽  
Rat Bone

PLEXIN-B2 promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the RhoA signaling pathway

2019 ◽  
Vol 62 ◽  
pp. 109343
Author(s):  
Ying Zhang ◽  
Sheng Shen ◽  
Peifeng Li ◽  
Yanan Fan ◽  
Leilei Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Signaling Pathway ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Marrow Mesenchymal Stem Cells ◽  
Rhoa Signaling

scholarly journals Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway

2019 ◽  
Vol 112 ◽  
pp. 108625 ◽  
Author(s):  
Li Lu ◽  
Guohu Chen ◽  
Jingjing Yang ◽  
Zhanjun Ma ◽  
Yang Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Marrow Mesenchymal Stem Cells ◽  
U251 Cells
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