Involvement of autophagy in the procedure of endoplasmic reticulum stress introduced apoptosis in bone marrow mesenchymal stem cells from nonobese diabetic mice

2016 ◽  
Vol 34 (1) ◽  
pp. 25-33 ◽  
Author(s):  
Yan Meng ◽  
Juan Ji ◽  
Wei Tan ◽  
Genkai Guo ◽  
Yunfei Xia ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Endoplasmic Reticulum ◽  
Mesenchymal Stem Cells ◽  
Endoplasmic Reticulum Stress ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Marrow Mesenchymal Stem Cells ◽  
Nonobese Diabetic Mice

scholarly journals Roles of Wnt/β-Catenin Signaling in Retinal Neuron-Like Differentiation of Bone Marrow Mesenchymal Stem Cells from Nonobese Diabetic Mice

2012 ◽  
Vol 49 (2) ◽  
pp. 250-261 ◽  
Author(s):  
Yue Xu ◽  
Zhifeng Gu ◽  
Biyu Shen ◽  
Guofeng Xu ◽  
Tianqiu Zhou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Diabetic Mice ◽  
Retinal Neuron ◽  
Nonobese Diabetic ◽  
Marrow Mesenchymal Stem Cells ◽  
Nonobese Diabetic Mice

Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells

2014 ◽  
Vol 31 (3) ◽  
pp. 314-328 ◽  
Author(s):  
Yih-An King ◽  
Yu-Jen Chiu ◽  
Hao-Ping Chen ◽  
Daih-Huang Kuo ◽  
Chi-Cheng Lu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Endoplasmic Reticulum ◽  
Mesenchymal Stem Cells ◽  
Endoplasmic Reticulum Stress ◽  
Arsenic Trioxide ◽  
Intrinsic Apoptosis ◽  
Marrow Mesenchymal Stem Cells

scholarly journals Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress through Regulation of CHOP and JNK in Bone Marrow Mesenchymal Stem Cells from Patients with Systemic Lupus Erythematosus

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Genkai Guo ◽  
Yan Meng ◽  
Wei Tan ◽  
Yunfei Xia ◽  
Chun Cheng ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Stem Cells ◽  
Bone Marrow ◽  
Endoplasmic Reticulum ◽  
Mesenchymal Stem Cells ◽  
Endoplasmic Reticulum Stress ◽  
Lupus Erythematosus ◽  
B Cell Lymphoma ◽  
Systemic Lupus ◽  
Marrow Mesenchymal Stem Cells

Previous studies indicated that bone marrow mesenchymal stem cells (BM-MSCs) from patients with systemic lupus erythematosus (SLE) exhibited the phenomenon of apoptosis. In this study, we aimed to investigate whether apoptosis of BM-MSCs from SLE patients were dysregulated. In this paper, endoplasmic reticulum stress (ERS) was evidenced by increased expression of phosphorylated protein kinase RNA-like ER kinase (PERK) and inositol-requiring protein-1 (IRE-1). We also found the activation of downstream target eukaryotic translation initiator factor 2α(eIF 2α) and CCAAT/enhancer-binding protein- (C/EBP-) homologous protein (CHOP) in BM-MSCs from SLE patients. Interestingly, we discovered that 4-phenylbutyric acid (4-PBA), a selective inhibitor of ERS, blocked the apoptosis of BM-MSCs from SLE patients and alleviated the level of Jun N-terminal kinase1/2 (JNK1/2) and CHOP. Furthermore, blockage of PERK signaling expression by siRNA not only significantly reduced the expression of CHOP, but also activated the anti-apoptotic regulator B-cell lymphoma-2 (Bcl-2). Blockage of IRE-1 or JNK1/2 by siRNA resulted in the decreased expression of JNK1/2 and proapoptosis protein Bcl-2 associated protein X (BAX). These results implicated that ERS-mediated apoptosis was a critical determinant of BM-MSCs from SLE patients.

Bone marrow mesenchymal stem cells promote the repair of islets from diabetic mice through paracrine actions

2014 ◽  
Vol 388 (1-2) ◽  
pp. 41-50 ◽  
Author(s):  
Xiaodong Gao ◽  
Lujun Song ◽  
Kuntang Shen ◽  
Hongshan Wang ◽  
Mengjia Qian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Diabetic Mice ◽  
Marrow Mesenchymal Stem Cells ◽  
Paracrine Actions

scholarly journals Bone Marrow-Derived Mesenchymal Stem Cells Protect Islet Grafts Against Endoplasmic Reticulum Stress-Induced Apoptosis During the Early Stage After Transplantation

Stem Cells ◽  
2018 ◽  
Vol 36 (7) ◽  
pp. 1045-1061 ◽  
Author(s):  
Ying He ◽  
Dongmei Zhang ◽  
Yi Zeng ◽  
Junlei Ma ◽  
Jing Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Endoplasmic Reticulum ◽  
Mesenchymal Stem Cells ◽  
Endoplasmic Reticulum Stress ◽  
Early Stage ◽  
Induced Apoptosis

scholarly journals Research Progress on the Role of Endoplasmic Reticulum Stress in Osteogenic Differentiation

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Nianqiang Jin ◽  
Hongchen Sun
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Osteogenic Differentiation ◽  
Treatment Strategies ◽  
Research Progress ◽  
Main Site ◽  
Marrow Mesenchymal Stem Cells

The endoplasmic reticulum (ER) is the main site for regulating protein synthesis and processing. Endoplasmic reticulum stress plays a role in regulating the osteogenic differentiation of stem cells and general osteoblasts. Bone marrow stromal cells (BMSCs, also known as bone marrow mesenchymal stem cells) are a group of progenitor cells that contain a small number of bone stem cells (SSCs) that rebuild cartilage, bone, stroma, and fat cells that support hematopoiesis and bone marrow. Therefore, due to their self-renewal and differentiation capabilities, they have become an important resource for researching regenerative medicine and tissue engineering treatment strategies. Exposure of osteoblasts to physical and biochemical stimuli facilitates rapid activation of early tissue repair processes in organisms. Therefore, the rational regulation of the induction conditions of osteoblasts has become a hot research topic. This article reviews the recent advances in the role of endoplasmic reticulum stress in the process of osteoblast differentiation.

Hypoxic Preconditioning Improves the Therapeutic Potential of Aging Bone Marrow Mesenchymal Stem Cells in Streptozotocin-Induced Type-1 Diabetic Mice

2016 ◽  
Vol 18 (5) ◽  
pp. 344-355 ◽  
Author(s):  
Muhammad Waseem ◽  
Irfan Khan ◽  
Hana'a Iqbal ◽  
Sana Eijaz ◽  
Shumaila Usman ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Potential ◽  
Hypoxic Preconditioning ◽  
Diabetic Mice ◽  
Marrow Mesenchymal Stem Cells

scholarly journals Mesenchymal Stem Cells Facilitate Mixed Hematopoietic Chimerism Induction and Prevent Onset of Diabetes in Nonobese Diabetic Mice

Pancreas ◽  
2011 ◽  
Vol 40 (6) ◽  
pp. 846-854 ◽  
Author(s):  
Sadaki Asari ◽  
Shin Itakura ◽  
Jeffrey Rawson ◽  
Taihei Ito ◽  
Ivan Todorov ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Hematopoietic Chimerism ◽  
Onset Of Diabetes ◽  
Nonobese Diabetic Mice
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