scholarly journals Pharmacometrics, Physiologically Based Pharmacokinetics , Quantitative Systems Pharmacology— What's Next?—Joining Mechanistic and Epidemiological Approaches

2019 ◽  
Vol 8 (6) ◽  
pp. 352-355 ◽  
Author(s):  
Stephan Schmidt ◽  
Sarah Kim ◽  
Valvanera Vozmediano ◽  
Rodrigo Cristofoletti ◽  
Almut G. Winterstein ◽  
...  
Keyword(s):  
Systems Pharmacology ◽  
Physiologically Based Pharmacokinetics ◽  
Quantitative Systems Pharmacology ◽  
Physiologically Based

scholarly journals Development of Prodrugs for PDT-Based Combination Therapy Using a Singlet-Oxygen-Sensitive Linker and Quantitative Systems Pharmacology

2019 ◽  
Vol 8 (12) ◽  
pp. 2198
Author(s):  
Luong Nguyen ◽  
Mengjie Li ◽  
Sukyung Woo ◽  
Youngjae You
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Current Treatment ◽  
Pbpk Modeling ◽  
Systems Pharmacology ◽  
Treatment Optimization ◽  
Efficacy Evaluation ◽  
Quantitative Systems Pharmacology ◽  
Physiologically Based ◽  
Oxygen Sensitive

Photodynamic therapy (PDT) has become an effective treatment for certain types of solid tumors. The combination of PDT with other therapies has been extensively investigated in recent years to improve its effectiveness and expand its applications. This focused review summarizes the development of a prodrug system in which anticancer drugs are activated locally at tumor sites during PDT treatment. The development of a singlet-oxygen-sensitive linker that can be conveniently conjugated to various drugs and efficiently cleaved to release intact drugs is recapitulated. The initial design of prodrugs, preliminary efficacy evaluation, pharmacokinetics study, and optimization using quantitative systems pharmacology is discussed. Current treatment optimization in animal models using physiologically based a pharmacokinetic (PBPK) modeling approach is also explored.

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