scholarly journals Development of Prodrugs for PDT-Based Combination Therapy Using a Singlet-Oxygen-Sensitive Linker and Quantitative Systems Pharmacology

2019 ◽  
Vol 8 (12) ◽  
pp. 2198
Author(s):  
Luong Nguyen ◽  
Mengjie Li ◽  
Sukyung Woo ◽  
Youngjae You
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Current Treatment ◽  
Pbpk Modeling ◽  
Systems Pharmacology ◽  
Treatment Optimization ◽  
Efficacy Evaluation ◽  
Quantitative Systems Pharmacology ◽  
Physiologically Based ◽  
Oxygen Sensitive

Photodynamic therapy (PDT) has become an effective treatment for certain types of solid tumors. The combination of PDT with other therapies has been extensively investigated in recent years to improve its effectiveness and expand its applications. This focused review summarizes the development of a prodrug system in which anticancer drugs are activated locally at tumor sites during PDT treatment. The development of a singlet-oxygen-sensitive linker that can be conveniently conjugated to various drugs and efficiently cleaved to release intact drugs is recapitulated. The initial design of prodrugs, preliminary efficacy evaluation, pharmacokinetics study, and optimization using quantitative systems pharmacology is discussed. Current treatment optimization in animal models using physiologically based a pharmacokinetic (PBPK) modeling approach is also explored.

scholarly journals Visible light-induced singlet oxygen-mediated intracellular disassembly of polymeric micelles co-loaded with a photosensitizer and an anticancer drug for enhanced photodynamic therapy

2015 ◽  
Vol 51 (49) ◽  
pp. 9995-9998 ◽  
Author(s):  
Gurusamy Saravanakumar ◽  
Junseok Lee ◽  
Jihoon Kim ◽  
Won Jong Kim
Keyword(s):  
Photodynamic Therapy ◽  
Visible Light ◽  
Singlet Oxygen ◽  
Anticancer Drug ◽  
Polymeric Micelles ◽  
Oxygen Sensitive

This communication demonstrates the enhanced photodynamic therapy by means of singlet oxygen sensitive micelle, photosensitizer and anticancer drug.

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

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