Physiologically Based Pharmacokinetic Models for Adults and Children Reveal a Role of Intracellular Tubulin Binding in Vincristine Disposition

Tubulin Binding ◽

Physiologically Based ◽

Adults And Children

Physiologically‐Based Pharmacokinetic Models as Enablers of Precision Dosing in Drug Development: Pivotal Role of the Human Mass Balance Study

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2092 ◽

2020 ◽

Vol 109 (1) ◽

pp. 51-54

Author(s):

Karen Rowland Yeo ◽

Karthik Venkatakrishnan

Keyword(s):

Drug Development ◽

Mass Balance ◽

Pivotal Role ◽

Pharmacokinetic Models ◽

Balance Study ◽

Physiologically Based ◽

Mass Balance Study

The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development

PROTEOMICS - CLINICAL APPLICATIONS ◽

10.1002/prca.201400147 ◽

2015 ◽

Vol 9 (7-8) ◽

pp. 732-744 ◽

Cited By ~ 21

Author(s):

Aki T. Heikkinen ◽

Floriane Lignet ◽

Paul Cutler ◽

Neil Parrott

Keyword(s):

Drug Development ◽

Small Molecule ◽

Pharmacokinetic Models ◽

Small Molecule Drug ◽

Using Physiologically-Based Pharmacokinetic Models to Incorporate Chemical and Non-Chemical Stressors into Cumulative Risk Assessment: A Case Study of Pesticide Exposures

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph9051971 ◽

2012 ◽

Vol 9 (5) ◽

pp. 1971-1983 ◽

Cited By ~ 7

Author(s):

Susan C. Wason ◽

Thomas J. Smith ◽

Melissa J. Perry ◽

Jonathan I. Levy

Keyword(s):

Risk Assessment ◽

Cumulative Risk ◽

Pharmacokinetic Models ◽

Pesticide Exposures ◽

Response to “The Link Between Pharmacodynamics and Physiologically Based Pharmacokinetic Models”

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2012.216 ◽

2012 ◽

Vol 93 (2) ◽

pp. 152-152 ◽

Cited By ~ 5

Author(s):

A Rostami-Hodjegan

Keyword(s):

Pharmacokinetic Models ◽

In Vitro to In Vivo Extrapolation of Metabolic Rate Constants for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-9 ◽

2016 ◽

pp. 185-210

Author(s):

Gregory L. Kedderis

Keyword(s):

Metabolic Rate ◽

Rate Constants ◽

Pharmacokinetic Models ◽

Physiologically Based ◽

In Vivo Extrapolation

Pharmacokinetic/Physiologically Based Pharmacokinetic Models in Integrated Risk Information System Assessments

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-16 ◽

2006 ◽

pp. 301-348 ◽

Cited By ~ 2

Author(s):

Robert De Woskin ◽

Chadwick Thompson ◽

Weihsueh Chiu ◽

Paul Schlosser ◽

Carolyn Smallwood ◽

...

Keyword(s):

Information System ◽

Risk Information ◽

Pharmacokinetic Models ◽

Integrated Risk ◽

Are Physiologically Based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site

The AAPS Journal ◽

10.1208/s12248-015-9796-7 ◽

2015 ◽

Vol 17 (5) ◽

pp. 1268-1279 ◽

Cited By ~ 9

Author(s):

Helen Musther ◽

Katherine L. Gill ◽

Manoranjenni Chetty ◽

Amin Rostami-Hodjegan ◽

Malcolm Rowland ◽

...

Keyword(s):

Sampling Site ◽

Pharmacokinetic Models ◽

Central Venous ◽

Physiologically Based ◽

The Right

Physiologically Based Pharmacokinetic Models in Reproductive and Developmental Toxicology

Reproductive and Developmental Toxicology ◽

10.1016/b978-0-12-804239-7.00004-4 ◽

2017 ◽

pp. 51-65

Author(s):

Kannan Krishnan ◽

Sandrine Fleur Chebekoue

Keyword(s):

Pharmacokinetic Models ◽

Developmental Toxicology ◽

Fetal Physiologically Based Pharmacokinetic Models: Systems Information on the Growth and Composition of Fetal Organs

Clinical Pharmacokinetics ◽

10.1007/s40262-018-0685-y ◽

2018 ◽

Vol 58 (2) ◽

pp. 235-262 ◽

Cited By ~ 10

Author(s):

Khaled Abduljalil ◽

Masoud Jamei ◽

Trevor N. Johnson

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based ◽

Fetal Organs

Physiologically based pharmacokinetic models to support modernized chemical safety assessment

Physiologically Based Pharmacokinetic (PBPK) Modeling ◽

10.1016/b978-0-12-818596-4.00012-6 ◽

2020 ◽

pp. 301-321

Author(s):

Miyoung Yoon

Keyword(s):

Safety Assessment ◽

Pharmacokinetic Models ◽

Chemical Safety ◽