The effect of saffron supplement on clinical outcomes and metabolic profiles in patients with active rheumatoid arthritis: A randomized, double‐blind, placebo‐controlled clinical trial

2020 ◽  
Vol 34 (7) ◽  
pp. 1650-1658 ◽  
Author(s):  
Zahra Hamidi ◽  
Naheed Aryaeian ◽  
Jamileh Abolghasemi ◽  
Fatemeh Shirani ◽  
Mahsa Hadidi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trial ◽  
Clinical Outcomes ◽  
Active Rheumatoid Arthritis ◽  
Controlled Clinical Trial ◽  
Metabolic Profiles ◽  
Double Blind ◽  
Double Blind Placebo

Effect of the cumin cyminum L. Intake on Weight Loss, Metabolic Profiles and Biomarkers of Oxidative Stress in Overweight Subjects: A Randomized Double-Blind Placebo-Controlled Clinical Trial

2015 ◽  
Vol 66 (2-3) ◽  
pp. 117-124 ◽  
Author(s):  
Mohsen Taghizadeh ◽  
Mohammad Reza Memarzadeh ◽  
Zatollah Asemi ◽  
Ahmad Esmaillzadeh
Keyword(s):  
Clinical Trial ◽  
Weight Loss ◽  
Serum Insulin ◽  
Controlled Clinical Trial ◽  
Metabolic Profiles ◽  
Double Blind ◽  
Insulin Metabolism ◽  
Double Blind Placebo ◽  
Cuminum Cyminum ◽  
Overweight Subjects

Background: The current study was performed to determine the effects of cumin cyminum L. intake on weight loss and metabolic profiles among overweight subjects. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 78 overweight subjects (male, n = 18; female, n = 60) aged 18-60 years old. Participants were randomly assigned into three groups to receive: (1) cumin cyminum L. capsule (n = 26); (2) orlistat120 capsule (n = 26) and (3) placebo (n = 26) three times a day for 8 weeks. Anthropometric measures and fasting blood samples were taken at baseline and after 8 weeks of intervention. Results: Consumption of the Cuminum cyminum L. and orlistat120 resulted in a similar significant decrease in weight (-1.1 ± 1.2 and -0.9 ± 1.5 vs. 0.2 ± 1.5 kg, respectively, p = 0.002) and BMI (-0.4 ± 0.5 and -0.4 ± 0.6 vs. 0.1 ± 0.6 kg/m2, respectively, p = 0.003) compared with placebo. In addition, taking Cuminum cyminum L., compared with orlistat and placebo, led to a significant reduction in serum insulin levels (-1.4 ± 4.5 vs. 1.3 ± 3.3 and 0.3 ± 2.2 µIU/ml, respectively, p = 0.02), HOMA-B (-5.4 ± 18.9 vs. 5.8 ± 13.3 and 1.0 ± 11.0, respectively, p = 0.02) and a significant rise in QUICKI (0.01 ± 0.01 vs. -0.005 ± 0.01 and -0.004 ± 0.01, respectively, p = 0.02). Conclusion: Taking cumin cyminum L. for eight weeks among overweight subjects had the same effects of orlistat120 on weight and BMI and beneficial effects on insulin metabolism compared with orlistat120 and placebo.

The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial

2017 ◽  
Vol 70 (4) ◽  
pp. 277-285 ◽  
Author(s):  
Mohsen Taghizadeh ◽  
Narjes Farzin ◽  
Sara Taheri ◽  
Mahnaz Mahlouji ◽  
Hossein Akbari ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Weight Loss ◽  
Dietary Supplements ◽  
Green Tea ◽  
Controlled Clinical Trial ◽  
Metabolic Profiles ◽  
Double Blind ◽  
Insulin Metabolism ◽  
Double Blind Placebo ◽  
Overweight Women

Background: This study was conducted to determine the effects of dietary supplements containing green tea, capsaicin and ginger extracts on weight loss and metabolic profiles among overweight women. Methods: This randomized double-blind placebo-controlled clinical trial was implemented among 50 overweight women. Participants were randomly divided into 2 groups. Group A received dietary supplements containing 125 mg green tea, 25 mg capsaicin and 50 mg ginger extracts (n = 25) group B received placebos (n = 25) twice with lunch and twice with dinner daily for 8 weeks. Results: Compared with placebo, taking dietary supplements containing green tea, capsaicin and ginger resulted in a significant decrease in weight (-1.8 ± 1.5 vs. +0.4 ± 1.2 kg, respectively, p < 0.001) and body mass index (BMI; -0.7 ± 0.5 vs. +0.1 ± 0.5 kg/m2, respectively, p < 0.001). In addition, subjects who received green tea, capsaicin and ginger co-supplements had significantly decreased serum insulin concentrations (-2.6 ± 3.9 vs. -0.6 ± 2.0 µIU/mL, p = 0.02), homeostatic model of assessment for insulin resistance (-0.5 ± 0.8 vs. -0.05 ± 0.6, p = 0.01), and increased quantitative insulin sensitivity check index (+0.01 ± 0.01 vs. +0.001 ± 0.01, p = 0.008) and plasma glutathione (GSH) levels (+73.8 ± 120.6 vs. -28.3 ± 193.4 µmol/L, p = 0.03) compared with the placebo. Conclusions: Our study indicated that taking green tea, capsaicin and ginger co-supplements for 8 weeks among overweight women had beneficial effects on weight, BMI, markers of insulin metabolism and plasma GSH levels.

The effect of hesperidin supplementation on metabolic profiles in patients with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial

2019 ◽  
Vol 59 (6) ◽  
pp. 2569-2577 ◽  
Author(s):  
Zahra Yari ◽  
Mina Movahedian ◽  
Hossein Imani ◽  
Seyed Moayed Alavian ◽  
Mehdi Hedayati ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Clinical Trial ◽  
Controlled Clinical Trial ◽  
Metabolic Profiles ◽  
Double Blind ◽  
Double Blind Placebo
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