Effect of an aqueous extract of Terminalia chebula on endothelial dysfunction, systemic inflammation, and lipid profile in type 2 diabetes mellitus: A randomized double‐blind, placebo‐controlled clinical study

2020 ◽  
Vol 34 (12) ◽  
pp. 3226-3235
Author(s):  
Usharani Pingali ◽  
Deepasree Sukumaran ◽  
Chandrasekhar Nutalapati
Pharmateca ◽  
2020 ◽  
Vol 12_2020 ◽  
pp. 38-48
Author(s):  
A.M. Mkrtumyan Mkrtumyan ◽  
S.V. Vorobyev Vorobyev ◽  
A.R. Volkova Volkova ◽  
N.V. Vorokhobina Vorokhobina ◽  
◽  
...  

2021 ◽  
Author(s):  
Punam Khobarkar ◽  
Jayant Gulhane ◽  
Amit Nakanekar

Abstract Type 2 Diabetes mellitus in obese persons is becoming threatening disease due to increasing prevalence of its microvascular and macro vascular complications. A multi targeted treatment can be considered better over single targeted treatment; in view of multiple pathways involved in pathogenesis of diabetes and its complications. This open labelled randomized controlled clinical Study was aimed to evaluate clinical efficacy of ‘Vidangadi Lauha’(An Ayurveda formulation) in comparison with metformin for obese type II diabetes mellitus. Participants were divided into two groups. Trial group received Vidangadi Lauha 5gm BID and control group received tablet metformin 500mg BID for duration of 3 months. Among 550 screened participants 120 participants were eligible, out of them 100 participants were enrolled and randomized by computer generated method, out of them 80 patients (40 in each group) completed the trial. Both the treatments were equally effective in reducing blood sugar fasting(F), post meal(PM) glycated Haemoglobin (HbA1C) and Body Mass Index (BMI). Vidangadi Lauha is more effective in reducing Ayurvedic Symptoms, waist hip ratio and cholesterol as compared to Metformin. High Density Lipoproteins (HDL) were improved by minor clinical difference in both the groups. Both the treatment does not have statistically significant effect in reducing Low Density Lipoproteins (LDL).


Author(s):  
Sara Pascoe-González ◽  
María Guadalupe Ramos-Zavala ◽  
Miguel Angel Buenrostro Ahued ◽  
Sandra Ofelia Hernández-González ◽  
Ernesto Germán Cardona-Muñoz ◽  
...  

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