Neuroprotective properties of ethanolic extract of Citrus unshiu Markovich peel through NADPH oxidase 2 inhibition in chemotherapy‐induced neuropathic pain animal model

2021 ◽  
Author(s):  
Aelee Jang ◽  
Go‐Eun Choi ◽  
Yoo‐Jeong Kim ◽  
Gil‐Hyun Lee ◽  
Kyung‐Yae Hyun
Keyword(s):  
Animal Model ◽  
Neuropathic Pain ◽  
Nadph Oxidase ◽  
Ethanolic Extract ◽  
Citrus Unshiu ◽  
Nadph Oxidase 2

scholarly journals NADPH Oxidase 2-Mediated Insult in the Auditory Cortex of Zucker Diabetic Fatty Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Zheng-De Du ◽  
Wei Wei ◽  
Shukui Yu ◽  
Qing-Ling Song ◽  
Ke Liu ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Nadph Oxidase ◽  
Auditory Cortex ◽  
Auditory System ◽  
Auditory Brainstem ◽  
Secondary Symptom ◽  
Zucker Diabetic Fatty Rats ◽  
Brainstem Response ◽  
Zdf Rats ◽  
Nadph Oxidase 2

Clinical data has confirmed that auditory impairment may be a secondary symptom of type 2 diabetes mellitus (T2DM). However, mechanisms underlying pathologic changes that occur in the auditory system, especially in the central auditory system (CAS), remain poorly understood. In this study, Zucker diabetic fatty (ZDF) rats were used as a T2DM rat model to observe ultrastructural alterations in the auditory cortex and investigate possible mechanisms underlying CAS damage in T2DM. The auditory brainstem response (ABR) of ZDF rats was found to be markedly elevated in low (8 kHz) and high (32 kHz) frequencies. Protein expression of NADPH oxidase 2 (NOX2) and its matching subunits P22phox, P47phox, and P67phox was increased in the auditory cortex of ZDF rats. Expression of 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of DNA oxidative damage, was also increased in the neuronal mitochondria of the auditory cortex of ZDF rats. Additionally, decreases in the mitochondrial total antioxidant capabilities (T-AOC), adenosine triphosphate (ATP) production, and mitochondrial membrane potential (MMP) were detected in the auditory cortex of ZDF rats, suggesting mitochondrial dysfunction. Transmission electron microscopy results indicated that ultrastructural damage had occurred to neurovascular units and mitochondria in the auditory cortex of ZDF rats. Furthermore, cytochrome c (Cyt c) translocation from mitochondria to cytoplasm and caspase 3-dependent apoptosis were also detected in the auditory cortex of ZDF rats. Consequently, the study demonstrated that T2DM may cause morphological damage to the CAS and that NOX2-associated mitochondrial oxidative damage and apoptosis may be partly responsible for this insult.

P.1.h.014 The involvement of CCK receptors in stress-induced antinociception in an animal model of neuropathic pain

2014 ◽  
Vol 24 ◽  
pp. S278
Author(s):  
E. Rohanirad ◽  
A. Mesdaghinia
Keyword(s):  
Animal Model ◽  
Neuropathic Pain ◽  
Cck Receptors

scholarly journals Nrf2 promotes reparative angiogenesis through regulation of NADPH oxidase-2 in oxygen-induced retinopathy

2016 ◽  
Vol 99 ◽  
pp. 234-243 ◽  
Author(s):  
Yanhong Wei ◽  
Junsong Gong ◽  
Zhenhua Xu ◽  
Elia J. Duh
Keyword(s):  
Nadph Oxidase ◽  
Oxygen Induced Retinopathy ◽  
Nadph Oxidase 2 ◽  
Reparative Angiogenesis

A P2X7 receptor antagonist attenuates experimental autoimmune myocarditis via suppressed myocardial CD4+ T and macrophage infiltration and NADPH oxidase 2/4 expression in mice

2014 ◽  
Vol 30 (4) ◽  
pp. 527-533 ◽  
Author(s):  
Hirofumi Zempo ◽  
Yoichiro Sugita ◽  
Masahito Ogawa ◽  
Ryo Watanabe ◽  
Jun-ichi Suzuki ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Receptor Antagonist ◽  
P2x7 Receptor ◽  
Macrophage Infiltration ◽  
Autoimmune Myocarditis ◽  
Experimental Autoimmune Myocarditis ◽  
Nadph Oxidase 2 ◽  
Experimental Autoimmune

scholarly journals Ethanolic extract of Aloe vera ameliorates sciatic nerve ligation induced neuropathic pain

2014 ◽  
Vol 33 (4) ◽  
pp. 208 ◽  
Author(s):  
Sujatha Dodoala ◽  
Sunitha Sampathi ◽  
Priyanka Punuru ◽  
Gopichand Chinta ◽  
Swetha Kanyadhara
Keyword(s):  
Neuropathic Pain ◽  
Sciatic Nerve ◽  
Aloe Vera ◽  
Ethanolic Extract
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