Phytochemicals mediated modulation of microRNAs and long non‐coding RNAs in cancer prevention and therapy

2021 ◽  
Author(s):  
Luis M. Ruiz‐Manriquez ◽  
Carolina Estrada‐Meza ◽  
Javier A. Benavides‐Aguilar ◽  
S. Janin Ledesma‐Pacheco ◽  
Andrea Torres‐Copado ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Non Coding Rnas ◽  
Prevention And Therapy

scholarly journals The Role of Sex-specific Long Non-coding RNAs in Cancer Prevention and Therapy

2021 ◽  
Vol 26 (2) ◽  
pp. 98-109
Author(s):  
Hye Kyung Song ◽  
Sun Young Kim
Keyword(s):  
Cancer Prevention ◽  
Non Coding Rnas ◽  
Prevention And Therapy

Leukotriene A4 Hydrolase as a Target for Cancer Prevention and Therapy

2004 ◽  
Vol 4 (3) ◽  
pp. 267-283 ◽  
Author(s):  
X. Chen ◽  
S. Wang ◽  
N. Wu ◽  
C. Yang
Keyword(s):  
Cancer Prevention ◽  
Leukotriene A4 Hydrolase ◽  
Leukotriene A4 ◽  
Prevention And Therapy

scholarly journals Modulation of Nrf2 and NF-κB Signaling Pathways by Naturally Occurring Compounds in Relation to Cancer Prevention and Therapy. Are Combinations Better Than Single Compounds?

2021 ◽  
Vol 22 (15) ◽  
pp. 8223
Author(s):  
Violetta Krajka-Kuźniak ◽  
Wanda Baer-Dubowska
Keyword(s):  
Cancer Prevention ◽  
Signaling Pathways ◽  
Current Knowledge ◽  
Cancer Chemoprevention ◽  
Antioxidant Response ◽  
Natural Food ◽  
Related Factor ◽  
Nuclear Factor ◽  
Edible Plant ◽  
Prevention And Therapy

Nrf2 (nuclear factor erythroid 2-related factor 2) and NF-κB (nuclear factor–kappa B) signaling pathways play a central role in suppressing or inducing inflammation and angiogenesis processes. Therefore, they are involved in many steps of carcinogenesis through cooperation with multiple signaling molecules and pathways. Targeting both transcription factors simultaneously may be considered an equally important strategy for cancer chemoprevention and therapy. Several hundreds of phytochemicals, mainly edible plant and vegetable components, were shown to activate Nrf2 and mediate antioxidant response. A similar number of phytochemicals was revealed to affect NF-κB. While activation of Nrf2 and inhibition of NF-κB may protect normal cells against cancer initiation and promotion, enhanced expression and activation in cancer cells may lead to resistance to conventional chemo- or radiotherapy. Most phytochemicals, through different mechanisms, activate Nrf2, but others, such as luteolin, can act as inhibitors of both Nrf2 and NF-κB. Despite many experimental data confirming the above mechanisms currently, limited evidence exists demonstrating such activity in humans. Combinations of phytochemicals resembling that in a natural food matrix but allowing higher concentrations may improve their modulating effect on Nrf2 and NF-κB and ultimately cancer prevention and therapy. This review presents the current knowledge on the effect of selected phytochemicals and their combinations on Nrf2 and NF-κB activities in the above context.

scholarly journals Lung Cancer Prevention and Therapy Using the JinFuKang Herbal Mixture

2015 ◽  
Vol 1 (5) ◽  
pp. 346-353 ◽  
Author(s):  
Lijing Jiao ◽  
Yian Wang ◽  
Ling Xu ◽  
Ming You
Keyword(s):  
Lung Cancer ◽  
Cancer Prevention ◽  
Herbal Mixture ◽  
Lung Cancer Prevention ◽  
Prevention And Therapy

scholarly journals Honokiol: A Novel Natural Agent for Cancer Prevention and Therapy

2012 ◽  
Vol 12 (10) ◽  
pp. 1244-1252 ◽  
Author(s):  
S. Arora ◽  
S. Singh ◽  
G.A. Piazza ◽  
C.M. Contreras ◽  
J. Panyam ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Natural Agent ◽  
Prevention And Therapy

Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations

2021 ◽  
pp. 105837
Author(s):  
Arijit Mondal ◽  
Sabyasachi Banerjee ◽  
Sankhadip Bose ◽  
Sujayita Mazumder ◽  
Rebecca A. Haber ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Prevention And Therapy

Breast cancer and sphingolipid signalling

2005 ◽  
Vol 72 (S1) ◽  
pp. 5-13 ◽  
Author(s):  
Paola Signorelli ◽  
Riccardo Ghidoni
Keyword(s):  
Breast Cancer ◽  
Cancer Prevention ◽  
Biological Membranes ◽  
Breast Cancer Prevention ◽  
Intracellular Signalling ◽  
Regulated Functions ◽  
Tumour Initiation ◽  
Prevention And Therapy

Cancer develops from overlapping events that tend to deregulate the metabolism and unbalance the homeostasis of cells. Sphingolipids, major components of biological membranes, are also mediators of intracellular signalling. Their metabolism can be influenced by diverse stimuli and the accumulation or deficiency of intermediates may trigger proliferation and/or impair the ability of damaged cells to undergo apoptosis. Many sphingolipid-regulated functions are implicated in tumour initiation, promotion, progression and responsiveness to chemotherapy. In this review, evidence of the alteration of sphingolipids metabolism and signalling will be discussed in breast cancer prevention and therapy.

Psychological intervention to treat distress: An emerging frontier in cancer prevention and therapy

2021 ◽  
pp. 188665
Author(s):  
Mei Yang ◽  
Zhe Zhang ◽  
Edouard C. Nice ◽  
Chuang Wang ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Psychological Intervention ◽  
Prevention And Therapy
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