Investigate dysregulated lipid metabolism in diabetic mice via targeted metabolomics of bile acids in enterohepatic circulation

2021 ◽  
Author(s):  
Yanjiao Ruan ◽  
Rong Liu ◽  
Lingzhi Gong
Keyword(s):  
Lipid Metabolism ◽  
Bile Acids ◽  
Enterohepatic Circulation ◽  
Diabetic Mice ◽  
Targeted Metabolomics

1060-P: The Effect of FGF21/GLP-1 Fusion Protein on Glucose and Lipid Metabolism Using Diabetic Mice Models

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1060-P
Author(s):  
LIXIN GUO ◽  
QI PAN ◽  
CHAO CHEN ◽  
SHUSHAN LIN ◽  
YU LI ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Fusion Protein ◽  
Diabetic Mice ◽  
Glucose And Lipid Metabolism

scholarly journals Physiology and Physical Chemistry of Bile Acids

2021 ◽  
Vol 22 (4) ◽  
pp. 1780
Author(s):  
Maria Chiara di Gregorio ◽  
Jacopo Cautela ◽  
Luciano Galantini
Keyword(s):  
Physical Chemistry ◽  
Bile Acids ◽  
Material Science ◽  
Metabolic Regulation ◽  
Enterohepatic Circulation ◽  
Building Blocks ◽  
The Body ◽  
Active Molecule ◽  
Supramolecular Aggregates ◽  
Biological Field

Bile acids (BAs) are facial amphiphiles synthesized in the body of all vertebrates. They undergo the enterohepatic circulation: they are produced in the liver, stored in the gallbladder, released in the intestine, taken into the bloodstream and lastly re-absorbed in the liver. During this pathway, BAs are modified in their molecular structure by the action of enzymes and bacteria. Such transformations allow them to acquire the chemical–physical properties needed for fulling several activities including metabolic regulation, antimicrobial functions and solubilization of lipids in digestion. The versatility of BAs in the physiological functions has inspired their use in many bio-applications, making them important tools for active molecule delivery, metabolic disease treatments and emulsification processes in food and drug industries. Moreover, moving over the borders of the biological field, BAs have been largely investigated as building blocks for the construction of supramolecular aggregates having peculiar structural, mechanical, chemical and optical properties. The review starts with a biological analysis of the BAs functions before progressively switching to a general overview of BAs in pharmacology and medicine applications. Lastly the focus moves to the BAs use in material science.

scholarly journals Effect of different bile acids on the intestine through enterohepatic circulation based on FXR

Gut Microbes ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1949095
Author(s):  
Junwei Xiang ◽  
Zhengyan Zhang ◽  
Hongyi Xie ◽  
Chengcheng Zhang ◽  
Yan Bai ◽  
...  
Keyword(s):  
Bile Acids ◽  
Enterohepatic Circulation

scholarly journals The economy of the enterohepatic circulation of bile acids in the baboon. 1. Studies of controlled enterohepatic circulation of bile acids.

1984 ◽  
Vol 25 (5) ◽  
pp. 428-436
Author(s):  
R N Redinger ◽  
J W Hawkins ◽  
D M Grace
Keyword(s):  
Bile Acids ◽  
Enterohepatic Circulation

Effects of low-carbohydrate diet and ketogenic diet on glucose and lipid metabolism in type 2 diabetic mice

Nutrition ◽  
2021 ◽  
pp. 111230
Author(s):  
Zi Yang ◽  
Jingyi Mi ◽  
Yu Wang ◽  
Lamei Xue ◽  
Jinxin Liu ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Ketogenic Diet ◽  
Diabetic Mice ◽  
Carbohydrate Diet ◽  
Low Carbohydrate Diet ◽  
Glucose And Lipid Metabolism ◽  
Low Carbohydrate ◽  
Type 2 Diabetic

Comparison of the effects of raw and cooked adzuki bean on glucose/lipid metabolism and liver function in diabetic mice

2021 ◽  
Author(s):  
Qingyu Zhao ◽  
Dianzhi Hou ◽  
Laraib Yousaf ◽  
Yong Xue ◽  
Qun Shen
Keyword(s):  
Lipid Metabolism ◽  
Liver Function ◽  
Adzuki Bean ◽  
Diabetic Mice

scholarly journals The ileal bile acid transporter inhibitor A4250 decreases serum bile acids by interrupting the enterohepatic circulation

2015 ◽  
Vol 43 (2) ◽  
pp. 303-310 ◽  
Author(s):  
H. Graffner ◽  
P.-G. Gillberg ◽  
L. Rikner ◽  
H.-U. Marschall
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Enterohepatic Circulation ◽  
Serum Bile Acids ◽  
Bile Acid Transporter ◽  
Acid Transporter

The enterohepatic circulation of bile acids in mammals: form and functions

10.2741/3399 ◽  
2009 ◽  
Vol Volume (14) ◽  
pp. 2584 ◽  
Author(s):  
Alan, F. Hofmann
Keyword(s):  
Bile Acids ◽  
Enterohepatic Circulation

Bile Acids: The Good, the Bad, and the Ugly

Physiology ◽  
1999 ◽  
Vol 14 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Alan F. Hofmann
Keyword(s):  
Bile Acids ◽  
Enterohepatic Circulation ◽  
Cholesterol Metabolism ◽  
Plasma Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Absorption ◽  
Bile Acid Metabolism ◽  
Cholesterol Levels ◽  
Density Lipoprotein Receptor

Bile acids, amphipathic end products of cholesterol metabolism, are “good” in the infant because they enhance lipid absorption and thereby promote growth. Bile acids also induce bile flow and biliary lipid secretion. The enterohepatic circulation of bile acids is “bad” in the adult because it downregulates hepatocyte low-density lipoprotein receptor activity and thereby elevates plasma cholesterol levels. Defects in bile acid metabolism such as impaired biosynthesis or transport are “ugly” because they cause morbidity and death. New approaches for treating these defects are being developed.

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