Bile Acids: The Good, the Bad, and the Ugly
Keyword(s):
Bile acids, amphipathic end products of cholesterol metabolism, are “good” in the infant because they enhance lipid absorption and thereby promote growth. Bile acids also induce bile flow and biliary lipid secretion. The enterohepatic circulation of bile acids is “bad” in the adult because it downregulates hepatocyte low-density lipoprotein receptor activity and thereby elevates plasma cholesterol levels. Defects in bile acid metabolism such as impaired biosynthesis or transport are “ugly” because they cause morbidity and death. New approaches for treating these defects are being developed.
2020 ◽
1996 ◽
Vol 97
(1)
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pp. 154-161
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I705 variant in the low density lipoprotein receptor gene has no effect on plasma cholesterol levels
2000 ◽
Vol 37
(9)
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pp. 713-715
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2020 ◽
2020 ◽
2006 ◽
Vol 748
(1)
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pp. 630-633
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