Tumor-pH-Responsive Dissociable Albumin-Tamoxifen Nanocomplexes Enabling Efficient Tumor Penetration and Hypoxia Relief for Enhanced Cancer Photodynamic Therapy

Small ◽  
2018 ◽  
Vol 14 (49) ◽  
pp. 1803262 ◽  
Author(s):  
Zhijuan Yang ◽  
Qian Chen ◽  
Jiawen Chen ◽  
Ziliang Dong ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Ph Responsive ◽  
Tumor Penetration ◽  
Tumor Ph

scholarly journals A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity

Theranostics ◽  
2017 ◽  
Vol 7 (10) ◽  
pp. 2746-2756 ◽  
Author(s):  
Xingshu Li ◽  
Bi-Yuan Zheng ◽  
Mei-Rong Ke ◽  
Yongfan Zhang ◽  
Jian-Dong Huang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Ph Responsive ◽  
Tumor Ph

Calcium phosphate-based organic–inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy

2016 ◽  
Vol 4 (5) ◽  
pp. 826-838 ◽  
Author(s):  
Takahiro Nomoto ◽  
Shigeto Fukushima ◽  
Michiaki Kumagai ◽  
Kozo Miyazaki ◽  
Aki Inoue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Calcium Phosphate ◽  
Ph Responsive ◽  
Inorganic Hybrid ◽  
Normal Tissues

Organic–inorganic hybrid nanocarriers permit efficient photodynamic therapy with reduced damage to normal tissues.

pH-responsive size-shrinkable mesoporous silica-based nanocarrier for improved tumor penetration and therapeutic efficacy

Nanoscale ◽  
2022 ◽  
Author(s):  
Yongju He ◽  
Xingyu Fan ◽  
Xiaozan Wu ◽  
Taishun Hu ◽  
Fangfang Zhou ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Mesoporous Silica ◽  
Therapeutic Efficacy ◽  
Anticancer Therapy ◽  
Major Obstacle ◽  
Drug Penetration ◽  
Ph Responsive ◽  
Tumor Penetration ◽  
Promising Strategy

Poor tumor penetration is a major obstacle to nanomedicine for achieving effective anticancer therapy. Tumor microenvironment-induced nanomedicine size shrinkage is a promising strategy to overcome the drug penetration barrier across...

pH-Responsive dopamine-based nanoparticles assembled via Schiff base bonds for synergistic anticancer therapy

2020 ◽  
Vol 56 (87) ◽  
pp. 13347-13350
Author(s):  
Hong Li ◽  
Yuanyuan Zhao ◽  
Yi Jia ◽  
Gang Chen ◽  
Junxia Peng ◽  
...  
Keyword(s):  
Schiff Base ◽  
Photodynamic Therapy ◽  
Anticancer Therapy ◽  
Ph Responsive ◽  
Drug Nanocarriers

Dopamine-based nanoparticles are constructed via Schiff base bonds to serve as pH-responsive drug nanocarriers for combined photodynamic therapy and chemotherapy.

Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy

2011 ◽  
Vol 47 (37) ◽  
pp. 10311 ◽  
Author(s):  
Xianchun Zhu ◽  
Wentong Lu ◽  
Yazhou Zhang ◽  
Aisha Reed ◽  
Brandon Newton ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Ph Responsive

Phthalocyanine-based photosensitizer with tumor-pH-responsive properties for cancer theranostics

2018 ◽  
Vol 6 (38) ◽  
pp. 6080-6088 ◽  
Author(s):  
Shufeng Yan ◽  
Jincan Chen ◽  
Liangzhi Cai ◽  
Peng Xu ◽  
Yaxin Zhang ◽  
...  
Keyword(s):  
Ph Responsive ◽  
Tumor Ph ◽  
Cancer Theranostics

A versatile phthalocyanine-based photosensitizer with tumor-pH-responsive properties for cancer theranostics.

pH-Responsive Magnetic Mesoporous Silica-Based Nanoplatform for Synergistic Photodynamic Therapy/Chemotherapy

2018 ◽  
Vol 10 (17) ◽  
pp. 15001-15011 ◽  
Author(s):  
Xiang-long Tang ◽  
Feng Jing ◽  
Ben-lan Lin ◽  
Sheng Cui ◽  
Ru-tong Yu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Ph Responsive ◽  
Magnetic Mesoporous Silica

Responsive agarose hydrogel incorporated with natural humic acid and MnO2 nanoparticles for effective relief of tumor hypoxia and enhanced photo-induced tumor therapy

2020 ◽  
Vol 8 (1) ◽  
pp. 353-369 ◽  
Author(s):  
Mengmeng Hou ◽  
Weiwei Liu ◽  
Lei Zhang ◽  
Leiyang Zhang ◽  
Zhigang Xu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Humic Acid ◽  
Tumor Microenvironment ◽  
Tumor Therapy ◽  
Tumor Hypoxia ◽  
Therapeutic Outcome ◽  
Severe Hypoxia ◽  
Tumor Penetration ◽  
Mno2 Nanoparticles ◽  
Agarose Hydrogel

In spite of widespread applications of nano-photosensitizers, poor tumor penetration and severe hypoxia in the tumor microenvironment (TME) always result in an undesirable therapeutic outcome of photodynamic therapy (PDT).

Tumor‐Exocytosed Exosome/Aggregation‐Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy

2020 ◽  
Vol 132 (33) ◽  
pp. 13940-13947 ◽  
Author(s):  
Daoming Zhu ◽  
Yanhong Duo ◽  
Meng Suo ◽  
Yonghua Zhao ◽  
Ligang Xia ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Aggregation Induced Emission ◽  
Tumor Penetration
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