pH-Responsive dopamine-based nanoparticles assembled via Schiff base bonds for synergistic anticancer therapy

2020 ◽  
Vol 56 (87) ◽  
pp. 13347-13350
Author(s):  
Hong Li ◽  
Yuanyuan Zhao ◽  
Yi Jia ◽  
Gang Chen ◽  
Junxia Peng ◽  
...  
Keyword(s):  
Schiff Base ◽  
Photodynamic Therapy ◽  
Anticancer Therapy ◽  
Ph Responsive ◽  
Drug Nanocarriers

Dopamine-based nanoparticles are constructed via Schiff base bonds to serve as pH-responsive drug nanocarriers for combined photodynamic therapy and chemotherapy.

Role of Exosomes in Photodynamic Anticancer Therapy

2020 ◽  
Vol 27 (40) ◽  
pp. 6815-6824 ◽  
Author(s):  
Yuan Jiang ◽  
Chuanshan Xu ◽  
Wingnang Leung ◽  
Mei Lin ◽  
Xiaowen Cai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Basic Principle ◽  
Photochemical Reaction ◽  
Cell Communication ◽  
Anticancer Therapy ◽  
Bioactive Molecules ◽  
Promising Alternative ◽  
Tumor Tissues ◽  
Significant Attention

Photodynamic Therapy (PDT) is a promising alternative treatment for malignancies based on photochemical reaction induced by Photosensitizers (PS) under light irradiation. Recent studies show that PDT caused the abundant release of exosomes from tumor tissues. It is well-known that exosomes as carriers play an important role in cell-cell communication through transporting many kinds of bioactive molecules (e.g. lipids, proteins, mRNA, miRNA and lncRNA). Therefore, to explore the role of exosomes in photodynamic anticancer therapy has been attracting significant attention. In the present paper, we will briefly introduce the basic principle of PDT and exosomes, and focus on discussing the role of exosomes in photodynamic anticancer therapy, to further enrich and boost the development of PDT.

Development of a novel Schiff base derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy

2017 ◽  
Vol 20 ◽  
pp. 182-188
Author(s):  
Yusei Shinohara ◽  
Yoshio Endo ◽  
Chiaki Abe ◽  
Ikkyu Shiba ◽  
Masahiro Ishizuka ◽  
...  
Keyword(s):  
Schiff Base ◽  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Base Derivative

Calcium phosphate-based organic–inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy

2016 ◽  
Vol 4 (5) ◽  
pp. 826-838 ◽  
Author(s):  
Takahiro Nomoto ◽  
Shigeto Fukushima ◽  
Michiaki Kumagai ◽  
Kozo Miyazaki ◽  
Aki Inoue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Calcium Phosphate ◽  
Ph Responsive ◽  
Inorganic Hybrid ◽  
Normal Tissues

Organic–inorganic hybrid nanocarriers permit efficient photodynamic therapy with reduced damage to normal tissues.

pH-responsive size-shrinkable mesoporous silica-based nanocarrier for improved tumor penetration and therapeutic efficacy

Nanoscale ◽  
2022 ◽  
Author(s):  
Yongju He ◽  
Xingyu Fan ◽  
Xiaozan Wu ◽  
Taishun Hu ◽  
Fangfang Zhou ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Mesoporous Silica ◽  
Therapeutic Efficacy ◽  
Anticancer Therapy ◽  
Major Obstacle ◽  
Drug Penetration ◽  
Ph Responsive ◽  
Tumor Penetration ◽  
Promising Strategy

Poor tumor penetration is a major obstacle to nanomedicine for achieving effective anticancer therapy. Tumor microenvironment-induced nanomedicine size shrinkage is a promising strategy to overcome the drug penetration barrier across...

Photocytotoxic Copper(II) Complexes with Schiff-Base Scaffolds for Photodynamic Therapy

2018 ◽  
Vol 24 (16) ◽  
pp. 4111-4120 ◽  
Author(s):  
Rong-Kai Lin ◽  
Chin-I Chiu ◽  
Cho-Han Hsu ◽  
Ying-Ju Lai ◽  
Parthiban Venkatesan ◽  
...  
Keyword(s):  
Schiff Base ◽  
Photodynamic Therapy

Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy

2011 ◽  
Vol 47 (37) ◽  
pp. 10311 ◽  
Author(s):  
Xianchun Zhu ◽  
Wentong Lu ◽  
Yazhou Zhang ◽  
Aisha Reed ◽  
Brandon Newton ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Ph Responsive

scholarly journals Activatable near-infrared emission-guided on-demand administration of photodynamic anticancer therapy with a theranostic nanoprobe

2019 ◽  
Vol 10 (9) ◽  
pp. 2785-2790 ◽  
Author(s):  
Rongchen Wang ◽  
Kaikai Dong ◽  
Ge Xu ◽  
Ben Shi ◽  
Tianli Zhu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Anticancer Therapy ◽  
Infrared Emission ◽  
Normal Tissues ◽  
On Demand ◽  
Near Infrared Emission

A theranostic platform enables the selective visualization of H2S-rich cancers and imaging-directed on-demand photodynamic therapy of the detected cancers while leaving normal tissues untouched.

Covalently assembled dopamine nanoparticle as an intrinsic photosensitizer and pH-responsive nanocarrier for potential application in anticancer therapy

2019 ◽  
Vol 55 (100) ◽  
pp. 15057-15060 ◽  
Author(s):  
Hong Li ◽  
Yuanyuan Zhao ◽  
Yi Jia ◽  
Chengtun Qu ◽  
Junbai Li
Keyword(s):  
Potential Application ◽  
Anticancer Therapy ◽  
Ph Responsive

A covalently assembled dopamine nanoparticle is constructed to serve as an intrinsic photosensitizer and pH-responsive drug nanocarrier for combined PDT and chemotherapy.

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