Ratiometric Imaging of MMP‐2 Activity Facilitates Tumor Detection Using Activatable Near‐Infrared Fluorescent Semiconducting Polymer Nanoparticles

Small ◽  
2021 ◽  
pp. 2101924
Author(s):  
Wenhui Zeng ◽  
Luyan Wu ◽  
Yidan Sun ◽  
Yuqi Wang ◽  
Jinfang Wang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Detection ◽  
Polymer Nanoparticles ◽  
Semiconducting Polymer ◽  
Ratiometric Imaging ◽  
Semiconducting Polymer Nanoparticles

scholarly journals Diketopyrrolopyrrole-based semiconducting polymer nanoparticles forin vivosecond near-infrared window imaging and image-guided tumor surgery

2018 ◽  
Vol 9 (12) ◽  
pp. 3105-3110 ◽  
Author(s):  
Kangquan Shou ◽  
Yufu Tang ◽  
Hao Chen ◽  
Si Chen ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Absorption Peak ◽  
Tumor Surgery ◽  
Clinical Imaging ◽  
Semiconducting Polymer ◽  
Image Guided ◽  
Infrared Window ◽  
Semiconducting Polymer Nanoparticles

PDFT1032, a new semiconducting polymer possessing a favorable absorption peak (1032 nm) and outstanding biocompatibility, may be widely applicable in clinical imaging and the surgical treatment of malignancy.

scholarly journals Metabolizable Semiconducting Polymer Nanoparticles for Second Near‐Infrared Photoacoustic Imaging

2019 ◽  
Vol 31 (11) ◽  
pp. 1808166 ◽  
Author(s):  
Yuyan Jiang ◽  
Paul Kumar Upputuri ◽  
Chen Xie ◽  
Ziling Zeng ◽  
Arunima Sharma ◽  
...  
Keyword(s):  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Polymer Nanoparticles ◽  
Semiconducting Polymer ◽  
Semiconducting Polymer Nanoparticles

scholarly journals Organic Semiconducting Polymer Nanoparticles for Photoacoustic Labeling and Tracking of Stem Cells in the Second Near-Infrared Window

ACS Nano ◽  
2018 ◽  
Vol 12 (12) ◽  
pp. 12201-12211 ◽  
Author(s):  
Chao Yin ◽  
Guohua Wen ◽  
Chao Liu ◽  
Boguang Yang ◽  
Sien Lin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Semiconducting Polymer ◽  
Infrared Window ◽  
Semiconducting Polymer Nanoparticles

scholarly journals Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window

Nano Letters ◽  
2017 ◽  
Vol 17 (8) ◽  
pp. 4964-4969 ◽  
Author(s):  
Yuyan Jiang ◽  
Paul Kumar Upputuri ◽  
Chen Xie ◽  
Yan Lyu ◽  
Lulu Zhang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Polymer Nanoparticles ◽  
Semiconducting Polymer ◽  
Infrared Window ◽  
Semiconducting Polymer Nanoparticles

scholarly journals Simultaneous Optimization of Excitation Wavelength and Emission Window for Semiconducting Polymer Nanoparticles to Improve Imaging Quality

2021 ◽  
Author(s):  
Dingwei Xue ◽  
Hongli Zhou ◽  
Zeyi Lu ◽  
Yuhuang Zhang ◽  
Mengyuan Li ◽  
...  
Keyword(s):  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Simultaneous Optimization ◽  
Tissue Imaging ◽  
Whole Body ◽  
Excitation Wavelength ◽  
Semiconducting Polymer ◽  
Imaging Quality ◽  
Deep Tissue Imaging ◽  
Semiconducting Polymer Nanoparticles

Optimized excitation wavelength and emission window are essential for fluorescence imaging with high quality. Semiconducting polymer nanoparticles (SPNs) as fluorescent contrast agents have been extensively studied, but their imaging abilities in the second near infrared IIb window (NIR-IIb, 1500 to 1700 nm) with long excitation wavelength have not been reported yet. Herein, as a proof-of-concept, we demonstrate for the first time that an SPN named L1057 nanoparticles (NPs) exhibit intense NIR-IIb signal due to its ultra-high brightness and broad emission spectrum. After screening 915 nm as an optimal excitation wavelength, we applied L1057 NPs to visualize the whole body vessels, cerebral vessels, gastrointestinal tract, and tumor progression in different stages, achieving superior spatial resolution and signal to background ratio in the NIR-IIb window with respect to NIR-II window (1000 to 1700 nm). This study reveals that simultaneous optimization of excitation wavelength and emission window is an efficient strategy to enhance imaging quality and that L1057 NPs can serve as a promising NIR-IIb contrast agent for high-resolution and deep-tissue imaging.

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