scholarly journals Engineered stem cells targeting multiple cell surface receptors in tumors

Stem Cells ◽  
2019 ◽  
Vol 38 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Sanam L. Kavari ◽  
Khalid Shah
Keyword(s):  
Stem Cells ◽  
Cell Surface ◽  
Cell Surface Receptors ◽  
Surface Receptors ◽  
Multiple Cell

Mesenchymal Stem Cells and Their Cell Surface Receptors

2008 ◽  
Vol 4 (3) ◽  
pp. 155-160 ◽  
Author(s):  
Denitsa Docheva ◽  
Florian Haasters ◽  
Matthias Schieker
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Surface ◽  
Cell Surface Receptors ◽  
Surface Receptors

Dual Electrochemiluminescence Signal System for In Situ and Simultaneous Evaluation of Multiple Cell-Surface Receptors

2017 ◽  
Vol 9 (3) ◽  
pp. 2074-2082 ◽  
Author(s):  
Bin Zhou ◽  
Youyi Qiu ◽  
Qingqing Wen ◽  
Mingyao Zhu ◽  
Peihui Yang
Keyword(s):  
Cell Surface ◽  
Cell Surface Receptors ◽  
Signal System ◽  
Surface Receptors ◽  
Simultaneous Evaluation ◽  
Multiple Cell

Heterobivalent Ligands Crosslink Multiple Cell-Surface Receptors — A Step Towards Personal Medicine

2009 ◽  
pp. 413-414 ◽  
Author(s):  
Jatinder S. Josan ◽  
Rajesh Sankaranarayanan ◽  
Heather L. Hand ◽  
Steve Fernandes ◽  
Liping Xu ◽  
...  
Keyword(s):  
Cell Surface ◽  
Cell Surface Receptors ◽  
Surface Receptors ◽  
Personal Medicine ◽  
Multiple Cell

scholarly journals Heterobivalent Ligands Crosslink Multiple Cell-Surface Receptors: The Human Melanocortin-4 and δ-Opioid Receptors

2008 ◽  
Vol 47 (9) ◽  
pp. 1685-1688 ◽  
Author(s):  
Josef Vagner ◽  
Liping Xu ◽  
Heather L. Handl ◽  
Jatinder S. Josan ◽  
David L. Morse ◽  
...  
Keyword(s):  
Cell Surface ◽  
Opioid Receptors ◽  
Cell Surface Receptors ◽  
Surface Receptors ◽  
Multiple Cell

scholarly journals Therapeutic Strategies for Targeting Ovarian Cancer Stem Cells

2021 ◽  
Vol 22 (10) ◽  
pp. 5059
Author(s):  
Wookyeom Yang ◽  
Dasol Kim ◽  
Dae Kyoung Kim ◽  
Kyung Un Choi ◽  
Dong Soo Suh ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cell Surface ◽  
Associated Factors ◽  
Cell Surface Receptors ◽  
Ovarian Cancer Stem Cells ◽  
Acquired Drug Resistance ◽  
Gynecological Malignancy ◽  
Surface Receptors

Ovarian cancer is a fatal gynecological malignancy. Although first-line chemotherapy and surgical operation are effective treatments for ovarian cancer, its clinical management remains a challenge owing to intrinsic or acquired drug resistance and relapse at local or distal lesions. Cancer stem cells (CSCs) are a small subpopulation of cells inside tumor tissues, and they can self-renew and differentiate. CSCs are responsible for the cancer malignancy involved in relapses as well as resistance to chemotherapy and radiation. These malignant properties of CSCs are regulated by cell surface receptors and intracellular pluripotency-associated factors triggered by internal or external stimuli from the tumor microenvironment. The malignancy of CSCs can be attenuated by individual or combined restraining of cell surface receptors and intracellular pluripotency-associated factors. Therefore, targeted therapy against CSCs is a feasible therapeutic tool against ovarian cancer. In this paper, we review the prominent roles of cell surface receptors and intracellular pluripotency-associated factors in mediating the stemness and malignancy of ovarian CSCs.

Heterobivalent Ligands Crosslink Multiple Cell-Surface Receptors: The Human Melanocortin-4 and δ-Opioid Receptors

2008 ◽  
Vol 120 (9) ◽  
pp. 1709-1712 ◽  
Author(s):  
Josef Vagner ◽  
Liping Xu ◽  
Heather L. Handl ◽  
Jatinder S. Josan ◽  
David L. Morse ◽  
...  
Keyword(s):  
Cell Surface ◽  
Opioid Receptors ◽  
Cell Surface Receptors ◽  
Surface Receptors ◽  
Multiple Cell

scholarly journals AAV-Mediated Gene Delivery to 3D Retinal Organoids Derived from Human Induced Pluripotent Stem Cells

2020 ◽  
Vol 21 (3) ◽  
pp. 994 ◽  
Author(s):  
Marcela Garita-Hernandez ◽  
Fiona Routet ◽  
Laure Guibbal ◽  
Hanen Khabou ◽  
Lyes Toualbi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Delivery ◽  
Cell Surface ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Transduction Efficiency ◽  
Cell Surface Receptors ◽  
Rpe Cells ◽  
Surface Receptors ◽  
Induced Pluripotent

Human induced pluripotent stem cells (hiPSCs) promise a great number of future applications to investigate retinal development, pathophysiology and cell therapies for retinal degenerative diseases. Specific approaches to genetically modulate hiPSC would be valuable for all of these applications. Vectors based on adeno-associated virus (AAV) have shown the ability for gene delivery to retinal organoids derived from hiPSCs. Thus far, little work has been carried out to investigate mechanisms of AAV-mediated gene delivery and the potential advantages of engineered AAVs to genetically modify retinal organoids. In this study, we compared the early transduction efficiency of several recombinant and engineered AAVs in hiPSC-derived RPE cells and retinal organoids in relation to the availability of their cell-surface receptors and as a function of time. The genetic variant AAV2-7m8 had a superior transduction efficiency when applied at day 44 of differentiation on retinal organoids and provided long-lasting expressions for at least 4 weeks after infection without compromising cell viability. All of the capsids we tested transduced the hiPSC-RPE cells, with the AAV2-7m8 variant being the most efficient. Transduction efficiency was correlated with the presence of primary cell-surface receptors on the hiPS-derived organoids. Our study explores some of the mechanisms of cell attachment of AAVs and reports long-term gene expression resulting from gene delivery in retinal organoids.

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