Development of porous chitosan-gelatin/hydroxyapatite composite scaffolds for hard tissue-engineering applications

2011 ◽  
Vol 6 (2) ◽  
pp. 135-143 ◽  
Author(s):  
C. Isikli ◽  
V. Hasirci ◽  
N. Hasirci
2019 ◽  
Vol 34 (4-5) ◽  
pp. 386-400 ◽  
Author(s):  
Moein Zarei ◽  
Nader Tanideh ◽  
Shahrokh Zare ◽  
Fatemeh Sari Aslani ◽  
Omid Koohi-Hosseinabadi ◽  
...  

In the present study, poly(3-hydroxybutyrate)-based composite scaffolds were prepared with multi-walled carbon nanotubes and hydroxyapatite nanoparticles for hard tissue engineering applications by electrospinning. All the prepared scaffolds showed connective porous structure, which were suitable for cell proliferation and migration. The mechanical properties of the poly(3-hydroxybutyrate) scaffold were improved by 0.5% of carbon nanotube addition, whereas the addition of hydroxyapatite nanoparticles up to 10% had an insignificant effect in tensile strength. However, scanning electron microscopy and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay results suggested that the mesenchymal stem cells attachment and their metabolic activities on the surface of the poly(3-hydroxybutyrate) scaffolds with hydroxyapatite were enhanced compared to poly(3-hydroxybutyrate) scaffolds. In addition, after 6 weeks of in vivo biocompatibility results in a model of rat indicated better tissue reactions for the scaffolds that contained hydroxyapatite. Overall, poly(3-hydroxybutyrate) composite scaffolds with 10% hydroxyapatite and 0.5% carbon nanotube showed optimal performances for the potential scaffold for hard tissue engineering application.


2020 ◽  
Vol 250 ◽  
pp. 116895
Author(s):  
P.T. Sudheesh Kumar ◽  
Sowmya Srinivasan ◽  
Vinoth-Kumar Lakshmanan ◽  
H. Tamura ◽  
S.V. Nair ◽  
...  

Author(s):  
Agnieszka Sobczak-Kupiec ◽  
Agnieszka Maria Tomala ◽  
Cristina Domínguez López ◽  
Anna Drabczyk ◽  
Bożena Tyliszczak

2013 ◽  
Vol 8 (2) ◽  
pp. 025011 ◽  
Author(s):  
Agda Aline Rocha de Oliveira ◽  
Dickson Alves de Souza ◽  
Luisa Lima Silveira Dias ◽  
Sandhra Maria de Carvalho ◽  
Herman Sander Mansur ◽  
...  

2010 ◽  
Vol 123-125 ◽  
pp. 771-774 ◽  
Author(s):  
Chanoknan Monthien ◽  
Kanjana Silikulrat ◽  
Gobwute Rujijanagul ◽  
Tawee Tunkasiri ◽  
Sittiporn Punyanitya ◽  
...  

During recent years, there have been efforts in developing nanocrystalline bioceramics, to enhance their mechanical and biological properties for use in hard tissue engineering applications. In this work, we study the effects of some sintering additive nanopowders dopants on the properties of the sintered HA structures. Calculated quantities of silica nanopowders are incorporate as dopants into dried HA nanopowder. The mixing powders are uniaxially compacted and then sintered at 1200°C by rate-controlled sintering method in air. Compositional, microstructural, morphological and mechanical characterizations are carried out on sintered HA samples.


RSC Advances ◽  
2016 ◽  
Vol 6 (70) ◽  
pp. 66037-66047 ◽  
Author(s):  
Ł. John ◽  
M. Janeta ◽  
M. Rajczakowska ◽  
J. Ejfler ◽  
D. Łydżba ◽  
...  

The biomimetic organic–inorganic scaffold with the chemical composition, structural dimensions, topography, and microstructural properties that fulfills the requirements for hard-tissue engineering was developed.


2011 ◽  
Vol 85 (3) ◽  
pp. 584-591 ◽  
Author(s):  
P.T. Sudheesh Kumar ◽  
Sowmya Srinivasan ◽  
Vinoth-Kumar Lakshmanan ◽  
H. Tamura ◽  
S.V. Nair ◽  
...  

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