EP15.09: First trimester detection of renal agenesis using 3D ultrasound and virtual reality

Background. With the introduction of three-dimensional (3D) ultrasound it has become possible to measure volumes. The relative increase in embryonic volume (EV) is much larger than that of the crown-rump length (CRL) over the same time period. We examined whether EV is a better parameter to determine growth restriction in fetuses with structural congenital abnormalities. Study Design, Subjects, and Outcome Measures. CRL and EV were measured using a Virtual Reality (VR) system in prospectively collected 3D ultrasound volumes of 56 fetuses diagnosed with structural congenital abnormalities in the first trimester of pregnancy (gestational age 7+5 to 14+5 weeks). Measured CRL and EV were converted to z-scores and to percentages of the expected mean using previously published reference curves of euploid fetuses. The one-sample t-test was performed to test significance. Results. The EV was smaller than expected for GA in fetuses with structural congenital abnormalities (−35% p<0.001, z-score −1.44 p<0.001), whereas CRL was not (−6.43% p=0.118, z-score −0.43 p=0.605). Conclusions. CRL is a less reliable parameter to determine growth restriction in fetuses with structural congenital abnormalities as compared with EV. By measuring EV, growth restriction in first-trimester fetuses with structural congenital abnormalities becomes more evident and enables an earlier detection of these cases.

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Placental volume measurement by 3D-ultrasound in the first trimester and prediction of fetal growth

Geburtshilfe und Frauenheilkunde ◽

10.1055/s-0028-1088601 ◽

2008 ◽

Vol 68 (S 01) ◽

Author(s):

B Meurer ◽

N Dinkel ◽

N Hart ◽

J Siemer ◽

...

Keyword(s):

Fetal Growth ◽

First Trimester ◽

3D Ultrasound ◽

Volume Measurement ◽

Placental Volume

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Three-Dimensional Sonographic Evaluation of the Position of the Fetal Conus Medullaris at First Trimester

Fetal Diagnosis and Therapy ◽

10.1159/000516516 ◽

2021 ◽

pp. 1-8

Author(s):

Ruben Ramirez Zegarra ◽

Nicola Volpe ◽

Evelina Bertelli ◽

Greta Michela Amorelli ◽

Luigi Ferraro ◽

...

Keyword(s):

Abdominal Wall ◽

Umbilical Cord ◽

Interobserver Agreement ◽

Interobserver Variability ◽

First Trimester ◽

3D Ultrasound ◽

Conus Medullaris ◽

Consecutive Series ◽

Fetal Life ◽

Umbilical Cord Insertion

Objective: The objective of this study was to assess the position of the conus medullaris (CM) at the first trimester 3D ultrasound in a cohort of structurally normal fetuses. Methods: This was a multicenter prospective study involving a consecutive series of structurally normal fetuses between 11 and 13 weeks of gestation (CRL between 45 and 84 mm). All fetuses were submitted to 3D transvaginal ultrasound using a sagittal view of the spine as the starting plane of acquisition. At offline analysis, the position of the CM was evaluated by 2 independent operators with a quantitative and a qualitative method: (1) the distance between the most caudal part of the CM and the distal end of the coccyx (CMCd) was measured; (2) a line perpendicular to the fetal spine joining the tip of the CM to the anterior abdominal wall was traced to determine the level of this line in relation to the umbilical cord insertion (conus to abdomen line, CAL). Interobserver agreement for the CCMd was evaluated. Linear regression analysis was used to determine the association between the CMCd and CRL, and a normal range was computed based on the best-fit model. The absence of congenital anomalies was confirmed in all cases after birth. Results: In the study period between December 2019 and March 2020, 143 fetuses were recruited. In 130 fetuses (90.9%), the visualization of the CM was feasible. The mean value of the CMCd was 1.09 ± 0.16 cm. The 95% limits of agreement for the interobserver variability in measurement of the CMCd were 0.24 and 0.26 cm. The interobserver variability based on the intra-class correlation coefficient (ICC) for the CCMd was good (ICC = 0.81). We found a positive linear relationship between the CCMd and CRL. In all these fetuses, the CAL encountered the abdominal wall at or above the level of the cord insertion. Conclusion: In normal fetuses, the assessment of the CM position is feasible at the first trimester 3D ultrasound with a good interobserver agreement. The CM level was never found below the fetal umbilical cord insertion, while the CMCd was noted to increase according to the gestational age, confirming the “ascension” of the CM during fetal life.

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Semilobar holoprosencephaly with associated cyclopia and radial aplasia: first trimester diagnosis by means of integrating 2D–3D ultrasound

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-009-0975-6 ◽

2009 ◽

Vol 280 (4) ◽

pp. 647-651 ◽

Cited By ~ 8

Author(s):

Banu Dane ◽

Cem Dane ◽

Figen Aksoy ◽

Murat Yayla

Keyword(s):

First Trimester ◽

3D Ultrasound ◽

Radial Aplasia

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OP05.01: 3D ultrasound volumetry-growth abnormalities of the gestational sac in the first trimester of pregnancy: relation to pregnancy outcome

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.4436 ◽

2007 ◽

Vol 30 (4) ◽

pp. 469-469

Author(s):

K. Koterova ◽

L. Krofta ◽

I. Kucerova ◽

H. Stefanovicova ◽

L. Haakova

Keyword(s):

Pregnancy Outcome ◽

First Trimester ◽

3D Ultrasound ◽

First Trimester Of Pregnancy ◽

Gestational Sac ◽

Growth Abnormalities

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Three-dimensional ultrasound first trimester fetal volume measurement and its relation to pregnancy outcome

Journal of Perinatal Medicine ◽

10.1515/jpm-2016-0315 ◽

2017 ◽

Vol 45 (9) ◽

Author(s):

Haitham A. Torky ◽

Asem A. Moussa ◽

Ali M. Ahmad ◽

Osama Dief ◽

Manar A. Eldesoouky ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Pregnancy Outcome ◽

Gestational Age ◽

Preterm Labor ◽

Three Dimensional ◽

First Trimester ◽

3D Ultrasound ◽

Secondary Outcome ◽

Crown Rump Length

AbstractAim of work:To determine whether fetal volume (FV) measured by three-dimensional (3D) ultrasound was able to detect fetuses at risk of low birth weight (primary outcome) and/or preterm labor (secondary outcome).Methods:One hundred pregnant women carrying a singleton living pregnancy who were sure of dates, and had a dating scan, with gestational age between 11 weeks and 13 weeks+6 days coming for routine first trimester nuchal translucency (NT) were examined by both two-dimensional (2D) and 3D ultrasound (Vocal System) for crown-rump length (CRL) and FV then followed up regularly every 4 weeks until 28 weeks then biweekly until 36 weeks then weekly until delivery both clinically and by ultrasound biometry.Findings:Eighty-seven cases had a normal outcome, while the remaining 13 cases had either preterm labor (four cases) or low-birth weight (nine cases). FV positively correlated with CRL (P=0.026), gestational age in weeks (P=0.002), neonatal body weight in grams (P=0.018) and neonatal body length at birth (P=0.04). A mean FV of 8.3 mmConclusion:3D assessment of FV in the first trimester provides an accurate method for predicting pregnancy outcome namely low birth weight and neonatal complications, however, it is a better positive predictor than a negative one.

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Usability of Virtual Reality for Anxiety Reduction During First Trimester Dilation & Curettage: A Qualitative Study [5A]

Obstetrics and Gynecology ◽

10.1097/01.aog.0000559352.73919.cc ◽

2019 ◽

Vol 133 (1) ◽

pp. 11S-11S

Author(s):

Ryan Woodson ◽

Shiliang Zhang ◽

Aparna Sridhar

Keyword(s):

Virtual Reality ◽

Qualitative Study ◽

First Trimester ◽

Anxiety Reduction

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Visualization of CFD Results in a Virtual Reality Environment

ASME 2009 Summer Bioengineering Conference, Parts A and B ◽

10.1115/sbc2009-205067 ◽

2009 ◽

Author(s):

Timothy J. Gundert ◽

Paul Hayden ◽

Raymond Q. Migrino ◽

John F. LaDisa

Keyword(s):

Virtual Reality ◽

3D Ultrasound ◽

Hemodynamic Parameters ◽

Imaging Data ◽

Resonance Imaging ◽

Virtual Reality Environment ◽

Spatial Dimensions ◽

Computational Fluid Dynamics Cfd ◽

Comprehensive Manner ◽

Magnetic Resonance Imaging Mri

Imaging modalities such as computed tomography, 3D ultrasound and magnetic resonance imaging (MRI) facilitate detailed viewing of vascular geometries [1], but lack the ability to directly measure important hemodynamic parameters associated with the onset and progression of cardiovascular disease (i.e. pressure, wall shear stress) [2]. Computational fluid dynamics (CFD) is a noninvasive tool to quantify these indices in vessels reconstructed from imaging data. Although image-based CFD can be used to relate altered hemodynamics to vascular disease, a disjunction exists between information gathered from 4-D CFD (3 spatial dimensions and time) and the 2-D screens where results are typically displayed. In contrast, 3D virtual reality environments can be used to visualize CFD results in a comprehensive manner.

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