scholarly journals Research on a rat model of genotype IV swine hepatitis E virus

2022 ◽  
Author(s):  
Zhijie Jian ◽  
Youyou Li ◽  
Zhiwen Xu ◽  
Jun Zhao ◽  
Fengqin Li ◽  
...  
Keyword(s):  
Rat Model ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Swine Hepatitis

scholarly journals Seasonal pattern of hepatitis E virus prevalence in swine in two different geographical areas of China

2013 ◽  
Vol 141 (11) ◽  
pp. 2403-2409 ◽  
Author(s):  
Y. H. LU ◽  
H. Z. QIAN ◽  
A. Q. HU ◽  
X. QIN ◽  
Q. W. JIANG ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Seasonal Pattern ◽  
Eastern China ◽  
Geographical Area ◽  
Hepatitis E ◽  
Southwestern China ◽  
Seasonal Patterns ◽  
Virus Prevalence ◽  
Swine Hepatitis ◽  
A Minor

SUMMARYWe studied seasonal patterns of swine hepatitis E virus (HEV) infection in China. From 2008 to 2011, 4200 swine bile specimens were collected for the detection of HEV RNA. A total of 92/2400 (3·83%) specimens in eastern China and 47/1800 (2·61%) specimens in southwestern China were positive for HEV. Seasonal patterns differing by geographical area were suggested. In eastern China, the major peak of HEV RNA prevalence was during March–April, with a minor peak during September–October, and a dip during July–August. In southwestern China, the peak was during September–October and the dip during March–April. The majority of subtype 4a cases (63/82, 76·83%) were detected in the first half of the year, while the majority of subtype 4b cases (26/29, 89·66%) were concentrated in the second half of the year, suggesting that different subtypes contribute to different peaks. Our results indicate that the distribution of HEV subtypes is associated with seasonal patterns.

Experimental infection of mongolian gerbils by a genotype 4 strain of swine hepatitis E virus

2009 ◽  
Vol 81 (9) ◽  
pp. 1591-1596 ◽  
Author(s):  
Wengui Li ◽  
Quan Sun ◽  
Ruiping She ◽  
Decheng Wang ◽  
Xinhui Duan ◽  
...  
Keyword(s):  
Experimental Infection ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Mongolian Gerbils ◽  
Genotype 4 ◽  
Swine Hepatitis

scholarly journals Induction of antibody and interferon-γ production in mice immunized with virus-like particles of swine hepatitis E virus

2014 ◽  
Vol 15 (4) ◽  
pp. 575 ◽  
Author(s):  
Young-Jo Song ◽  
Woo-Jung Park ◽  
Seul-Kee Lee ◽  
Joong-Bok Lee ◽  
Seung-Yong Park ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Interferon Γ ◽  
Virus Like Particles ◽  
Swine Hepatitis

scholarly journals Detection of Human Food-Borne and Zoonotic Viruses on Irrigated, Field-Grown Strawberries

2012 ◽  
Vol 78 (10) ◽  
pp. 3763-3766 ◽  
Author(s):  
Julie Brassard ◽  
Marie-Josée Gagné ◽  
Mylène Généreux ◽  
Caroline Côté
Keyword(s):  
Irrigation Water ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Human Food ◽  
Food Borne ◽  
Zoonotic Viruses ◽  
Swine Hepatitis

ABSTRACTThis study evaluated the presence of pathogenic human and zoonotic viruses on irrigated, field-grown strawberries. Norovirus genogroup I, rotavirus, and swine hepatitis E virus genogroup 3 were detected on strawberries, and irrigation water is suspected as the contamination origin.

scholarly journals Molecular characterization of swine hepatitis E virus from Southeastern Brazil

2007 ◽  
Vol 38 (4) ◽  
pp. 693-698 ◽  
Author(s):  
Helder Henrique Paiva ◽  
Valentina Tzaneva ◽  
Rodrigo Haddad ◽  
Jonny Yokosawa
Keyword(s):  
Molecular Characterization ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Southeastern Brazil ◽  
Swine Hepatitis

scholarly journals Synthetic Peptides Containing Three Neutralizing Epitopes of Genotype 4 Swine Hepatitis E Virus ORF2 induced Protection against Swine HEV Infection in Rabbit

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 178
Author(s):  
Yiyang Chen ◽  
Tianxiang Chen ◽  
Yuhang Luo ◽  
Jie Fan ◽  
Meimei Zhang ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Keyhole Limpet Hemocyanin ◽  
Hepatitis E ◽  
Genotype 4 ◽  
Virus Shedding ◽  
Fecal Shedding ◽  
Orf2 Protein ◽  
Swine Hepatitis ◽  
Phosphate Buffered Saline ◽  
Neutralizing Epitopes

Genotype 4 hepatitis E virus (HEV) is a zoonotic pathogen transmitted to humans through food and water. Previously, three genotype 4 swine HEV ORF2 peptides (407EPTV410, 410VKLYTS415, and 458PSRPF462) were identified as epitopes of virus-neutralizing monoclonal antibodies that partially blocked rabbit infection with swine HEV. Here, individual and tandem fused peptides were synthesized, conjugated to keyhole limpet hemocyanin (KLH), then evaluated for immunoprotection of rabbits against swine HEV infection. Forty New Zealand White rabbits were randomly assigned to eight groups; groups 1 thru 5 received three immunizations with EPTV-KLH, VKLYTS-KLH, PSRPF-KLH, EPTVKLYTS-KLH, or EPTVKLYTSPSRPF-KLH, respectively; group 6 received truncated swine HEV ORF2 protein (sp239), and group 7 received phosphate-buffered saline. After an intravenous swine HEV challenge, all group 7 rabbits exhibited viremia and fecal virus shedding by 2–4 weeks post challenge (wpc), seroconversion by 4–9 wpc, elevated alanine aminotransferase (ALT) at 2 wpc, and severe liver lymphocytic venous periphlebitis. Only 1–2 rabbits/group in groups 1–4 exhibited delayed viremia, fecal shedding, seroconversion, increased ALT levels, and slight liver lymphocytic venous periphlebitis; groups 5–6 showed no pathogenic effects. Collectively, these results demonstrate that immunization with a polypeptide containing three genotype 4 HEV ORF2 neutralizing epitopes completely protected rabbits against swine HEV infection.

scholarly journals A rat model for hepatitis E virus

2016 ◽  
Vol 9 (10) ◽  
pp. 1203-1210 ◽  
Author(s):  
Yannick Debing ◽  
Niraj Mishra ◽  
Erik Verbeken ◽  
Kaat Ramaekers ◽  
Kai Dallmeier ◽  
...  
Keyword(s):  
Rat Model ◽  
Hepatitis E Virus ◽  
Hepatitis E
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