Stimulation of Calf Thymus DNA Polymerase α Activity by Nucleolar Protein B23

1994 ◽  
Vol 199 (1) ◽  
pp. 46-51 ◽  
Author(s):  
M. Takemura ◽  
N. Ohta ◽  
Y. Furuichi ◽  
T. Takahashi ◽  
S. Yoshida ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Nucleolar Protein ◽  
Calf Thymus Dna ◽  
Dna Polymerase Α ◽  
Calf Thymus ◽  
Protein B23 ◽  
Α Activity ◽  
Stimulation Of

scholarly journals Interactions of calf thymus DNA polymerase α with primer/templates

1995 ◽  
Vol 23 (20) ◽  
pp. 4109-4115 ◽  
Author(s):  
Harry C. Thompson ◽  
Robert J. Sheaff ◽  
Robert D. Kuchta
Keyword(s):  
Dna Polymerase ◽  
Calf Thymus Dna ◽  
Dna Polymerase Α ◽  
Calf Thymus

scholarly journals Apparent stimulation of calf thymus DNA polymerase alpha by ATP

1987 ◽  
Vol 15 (5) ◽  
pp. 2269-2278 ◽  
Author(s):  
Cheng-Keat Tan ◽  
Mary June So ◽  
Kathleen M. Downey ◽  
Antero G. So
Keyword(s):  
Dna Polymerase ◽  
Calf Thymus Dna ◽  
Dna Polymerase Alpha ◽  
Calf Thymus ◽  
Stimulation Of

Molecular mechanisms of impaired stimulation of DNA synthesis in cultured hepatocytes of aged rats

1998 ◽  
Vol 275 (1) ◽  
pp. C146-C154 ◽  
Author(s):  
Shoichi Kitano ◽  
Timothy W. Fawcett ◽  
Yoshikage Yo ◽  
George S. Roth
Keyword(s):  
Protein Kinase ◽  
Dna Synthesis ◽  
Dna Polymerase ◽  
Mitogen Activated Protein Kinase ◽  
Cultured Hepatocytes ◽  
Dna Polymerase Α ◽  
Mitogen Activated Protein ◽  
Old Rats ◽  
Α Activity ◽  
Stimulation Of

We examined epidermal growth factor (EGF)- and epinephrine-stimulated mitogen-activated protein kinase kinase (MEK) 1 and MEK2 activities, DNA polymerase α activity, and EGF-stimulated E2F DNA binding activity in primary cultured hepatocytes from 6- and 24-mo-old rats. MEK stimulation by either EGF or epinephrine was not altered with aging. However, stimulation of DNA polymerase α activity by these agents was 70% and 50% lower, respectively, in cells of aged compared with cells of young rats, consistent with a lesser increase in [3H]thymidine incorporation. EGF-stimulated E2F (a transcription factor that regulates expression of the DNA polymerase α gene) binding to DNA was reduced with age. PD-098059, a specific inhibitor of MEK, inhibited EGF-stimulated MEK1 and MEK2 activities in hepatocytes from 6- and 24-mo-old rats. Although PD-098059 inhibited EGF-stimulated DNA synthesis in hepatocytes from 6-mo-old rats, it had no effect in 24-mo-old rats. Thus the age-related impairment appears to occur before E2F activation, and signal transduction sequences other than the mitogen-activated protein kinase pathway may be involved in stimulated DNA synthesis in hepatocytes from old rats.

Stimulation of DNA Polymerase α Activity by Cdk2-Phosphorylated Rb Protein

2001 ◽  
Vol 282 (4) ◽  
pp. 984-990 ◽  
Author(s):  
Masaharu Takemura ◽  
Takashi Yamamoto ◽  
Masatoshi Kitagawa ◽  
Yoichi Taya ◽  
Tetsu Akiyama ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Rb Protein ◽  
Dna Polymerase Α ◽  
Α Activity ◽  
Stimulation Of

Effects of the anticancer drug cis-diamminedichloroplatinum(II) on the activities of calf thymus DNA polymerase .epsilon.

Biochemistry ◽  
1993 ◽  
Vol 32 (3) ◽  
pp. 841-848 ◽  
Author(s):  
Lin Huang ◽  
John J. Turchi ◽  
Alan F. Wahl ◽  
Robert A. Bambara
Keyword(s):  
Dna Polymerase ◽  
Anticancer Drug ◽  
Calf Thymus Dna ◽  
Dna Polymerase Epsilon ◽  
Calf Thymus ◽  
Polymerase Epsilon
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