Preparation, Purification, and Spectrophotometric Characterization of Cytochrome P450 1A2 Conjugated with Polyethylene Glycol Monomethyl Ether

1996 ◽  
Vol 222 (2) ◽  
pp. 406-409 ◽  
Author(s):  
Roya Nakhgevany ◽  
Osei Bonsu ◽  
Jousephine Barber ◽  
Patricia Ann Mabrouk ◽  
Yune-Fang Ueng ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Polyethylene Glycol ◽  
Monomethyl Ether ◽  
Cytochrome P450 1A2 ◽  
Glycol Monomethyl Ether

Synthesis and Characterization of Novel Amphiphilic Helical Copolymer

2011 ◽  
Vol 239-242 ◽  
pp. 1711-1716 ◽  
Author(s):  
Dong Mei Yue ◽  
Dong Zhao ◽  
Ting Yu ◽  
Wei Min Wang ◽  
Li Qun Zhang
Keyword(s):  
Polyethylene Glycol ◽  
Optical Activity ◽  
Monomethyl Ether ◽  
Synthesis And Characterization ◽  
Glycol Monomethyl Ether ◽  
Amplification Effect ◽  
Molecular Weights ◽  
Chiral Amplification ◽  
Environmental Stimulation

The new comb-copolymers [polyacetylene–MPEG (polyethylene glycol monomethyl ether)] were synthesized with (nbd)Rh+[η6-C6H5B- (C6H5)3] as catalyst. The copolymers with moderate molecular weights (Mn) (13000-170000) and yields (31.6-47.3%) exhibited higher optical activities compared with chiral monomer, which accorded with the “Chiral Amplification” effect. The optical activity of the copolymers gradually decreased as the amount of MPEG increased. The maximum amounts of MPEG for successful copolymerization and optical activity of copolymers were 40%, 30%, 20%(mol%) as the Mn of MPEG was 350, 750,1900, respectively. The optical activity of copolymers could change at external environmental stimulation, e.g., decreased as methanol content increased.

Conformational Studies of Synthetic Polyethylene Glycol Bound Substance P and its Lower Analogues

1985 ◽  
Vol 40 (11) ◽  
pp. 1570-1574 ◽  
Author(s):  
Piotr Koziej ◽  
Manfred Mutter
Keyword(s):  
Polyethylene Glycol ◽  
Substance P ◽  
Gel Permeation Chromatography ◽  
Monomethyl Ether ◽  
Terminal Part ◽  
Binding Studies ◽  
Glycol Monomethyl Ether ◽  
Conformational Studies ◽  
In Vivo Assays

The synthesis of Substance P (SP) bound at the C-terminal methionine to polyethylene glycol monomethyl ether (M-PEG) is described. SP-PEG-M is obtained in good yield by the liquidphase peptide synthesis. Gel permeation chromatography reveals that aggregated forms of the PEG-bound peptides are absent in CHCl3. CD and IR spectra point to a β-turn located at the N-terminal part of SP-PEG-M. In binding studies and in vivo assays the described compounds are devoid of biological activity.

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