Glutamic Acid Decarboxylase (GAD 67) Gene Expression in the Pancreas and Brain of the Nonobese Diabetic Mouse

1996 ◽  
Vol 224 (3) ◽  
pp. 747-753 ◽  
Author(s):  
Jean-Marie Pleau ◽  
Anne Esling ◽  
Christophe Van Acker ◽  
Mireille Dardenne
Keyword(s):  
Gene Expression ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Diabetic Mouse ◽  
Acid Decarboxylase ◽  
Nonobese Diabetic Mouse ◽  
Nonobese Diabetic

scholarly journals Localization of gamma-aminobutyric acid and glutamic acid decarboxylase in the pancreas of the nonobese diabetic mouse.

Endocrinology ◽  
1996 ◽  
Vol 137 (8) ◽  
pp. 3497-3506 ◽  
Author(s):  
F Saravia-Fernandez ◽  
C Faveeuw ◽  
C Blasquez-Bulant ◽  
M Tappaz ◽  
M Throsby ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Diabetic Mouse ◽  
Aminobutyric Acid ◽  
Acid Decarboxylase ◽  
Gamma Aminobutyric Acid ◽  
Nonobese Diabetic Mouse ◽  
Nonobese Diabetic

scholarly journals Normal Incidence of Diabetes in NOD Mice Tolerant to Glutamic Acid Decarboxylase

2003 ◽  
Vol 197 (12) ◽  
pp. 1635-1644 ◽  
Author(s):  
Elmar Jaeckel ◽  
Ludger Klein ◽  
Natalia Martin-Orozco ◽  
Harald von Boehmer
Keyword(s):  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Tolerance Induction ◽  
Nod Mice ◽  
Normal Incidence ◽  
Invariant Chain ◽  
Acid Decarboxylase ◽  
Β Cells ◽  
Nonobese Diabetic ◽  
Specific Tolerance

Experiments in nonobese diabetic (NOD) mice that lacked expression of glutamic acid decarboxylase (GAD) in β cells have suggested that GAD represents an autoantigen essential for initiating and maintaining the diabetogenic immune response. Several attempts of inducing GAD-specific recessive tolerance to support this hypothesis have failed. Here we report on successful tolerance induction by expressing a modified form of GAD under control of the invariant chain promoter resulting in efficient epitope display. In spite of specific tolerance insulitis and diabetes occurred with normal kinetics indicating that GAD is not an essential autoantigen in the pathogenesis of diabetes.

Localization of Glutamic Acid Decarboxylase in the Kidneys of Nonobese Diabetic Mice

Nephron ◽  
1996 ◽  
Vol 72 (4) ◽  
pp. 662-666 ◽  
Author(s):  
Zhi-Hong Liu ◽  
Liliane J. Striker ◽  
M. Hattori ◽  
Chih-Wei Yang ◽  
Gary E. Striker
Keyword(s):  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Acid Decarboxylase ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Nonobese Diabetic Mice

scholarly journals Cortical Gene Expression After a Conditional Knockout of 67 kDa Glutamic Acid Decarboxylase in Parvalbumin Neurons

2016 ◽  
Vol 42 (4) ◽  
pp. 992-1002 ◽  
Author(s):  
Danko Georgiev ◽  
Toru Yoshihara ◽  
Rika Kawabata ◽  
Takurou Matsubara ◽  
Makoto Tsubomoto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Conditional Knockout ◽  
Acid Decarboxylase ◽  
Parvalbumin Neurons

Prevention of Autoimmune Diabetes in Nonobese Diabetic Female Mice by Treatment with Recombinant Glutamic Acid Decarboxylase (GAD 65)

1995 ◽  
Vol 76 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Jean-Marie Pleau ◽  
Flavia Fernandez-Saravia ◽  
Anne Esling ◽  
Françoise Homo-Delarche ◽  
Mireille Dardenne
Keyword(s):  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Autoimmune Diabetes ◽  
Acid Decarboxylase ◽  
Female Mice ◽  
Nonobese Diabetic ◽  
Gad 65
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