NMDA and HIV-1 Coat Protein, GP120, Produce Necrotic but Not Apoptotic Cell Death in Human CHP100 Neuroblastoma Cultures via a Mechanism Involving Calpain

1996 ◽  
Vol 229 (1) ◽  
pp. 299-304 ◽  
Author(s):  
M.Tiziana Corasaniti ◽  
Michele Navarra ◽  
M.Valeria Catani ◽  
Gerry Melino ◽  
giuseppe Nisticò ◽  
...  
Keyword(s):  
Cell Death ◽  
Coat Protein ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Protein Gp120 ◽  
Hiv 1

Infection and Apoptotic Cell Death of CD4+T Cells during an Immune Response to HIV-1-Pulsed Dendritic Cells

1994 ◽  
Vol 10 (1) ◽  
pp. 61-71 ◽  
Author(s):  
P. U. CAMERON ◽  
M. POPE ◽  
S. GEZELTER ◽  
R. M. STEINMAN
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Cell Death ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Hiv 1

scholarly journals HIV-1 coat protein gp120 stimulates interleukin-1β secretion from human neuroblastoma cells: evidence for a role in the mechanism of cell death

2001 ◽  
Vol 134 (6) ◽  
pp. 1344-1350 ◽  
Author(s):  
Maria Tiziana Corasaniti ◽  
Anna Bilotta ◽  
Maria Concetta Strongoli ◽  
Michele Navarra ◽  
Giacinto Bagetta ◽  
...  
Keyword(s):  
Cell Death ◽  
Coat Protein ◽  
Neuroblastoma Cells ◽  
Interleukin 1Β ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Protein Gp120 ◽  
Hiv 1

scholarly journals HIV-1 Vpr-induced Proinflammatory Response and Apoptosis are Mediated through the Sur1-Trpm4 Channel in Astrocytes

2020 ◽  
Author(s):  
Ge Li ◽  
Tapas Makar ◽  
Volodymyr Gerzanich ◽  
Sudhakar Kalakonda ◽  
Svetlana Ivanova ◽  
...  
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Suicide Mortality ◽  
Proinflammatory Response ◽  
Antiretroviral Therapies ◽  
Proinflammatory Responses ◽  
Trpm4 Channel ◽  
Living With Hiv ◽  
Hiv 1

AbstractThere are about 38 million people currently living with HIV/AIDS worldwide. Successful treatment with combinational antiretroviral therapies (cART) can eliminate active replicating viruses and prolong lives to nearly normal lifespans. However, the new challenge faced by more than half of those HIV-infected and aging patients is chronic CNS neuroinflammation, which leads to HIV-associated neurocognitive disorders (HAND). While severe and progressive HAND has decreased significantly due to cART, chronic HAND often persists, resulting in high rates of delirium, dementia and depression that could lead to suicide. Indeed, the risk of suicide mortality in HIV-infected persons is significantly higher than in HIV-uninfected counterparts. Nevertheless, the mechanism of neuropathogenesis underlying HAND is not well understood. HAND is typically characterized by HIV-mediated glial neuroinflammation and neurotoxicity. Interestingly, the severity of some HAND does not always correlate with the levels of HIV, but rather with glial activation, suggesting other HIV-associated factors, not the whole virus per se, contribute to those HAND. HIV-1 viral protein R (Vpr) might be one of those viral factors, because Vpr induces neuroinflammation and causes neuronal apoptosis. The objective of this study was to delineate the specific role(s) of Vpr in activation of host neuroinflammation and neurotoxicity, as well as its contribution to HAND.In this report, we show correlations between HIV expression and activation of proinflammatory markers (TLR4, TNFα, and NFκB) and the Sur1-Trpm4 channel in astrocytes of HIV-infected postmortem human and transgenic mouse brain tissues. We further show that Vpr alone activate the same set of proinflammatory markers in an astrocytic cell line SNB19. Vpr-induced host cell proinflammatory responses result in apoptotic cell death. Together, our data suggest that HIV-1 Vpr-induced proinflammatory response and apoptotic cell death are mediated through the Sur1-Trpm4 channel in astrocytes.

Inhibitory effect of the immunosuppressant FK506 on apoptotic cell death induced by HIV-1 gp120

1995 ◽  
Vol 15 (6) ◽  
pp. 312-317 ◽  
Author(s):  
Iwao Sekigawa ◽  
Kazuhiko Koshino ◽  
Takashi Hishikawa ◽  
Hiroshi Kaneko ◽  
Yoshinari Takasaki ◽  
...  
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Inhibitory Effect ◽  
Apoptotic Cell Death ◽  
Hiv 1

The protective effect of lipophilic iron chelator 2, 2′-dipyridyl after focal cerebral ischemia closely correlates with limitation of apoptotic cell death

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S482-S482
Author(s):  
Michaël C Van Hoecke ◽  
Anne Prigent-Tessier ◽  
Philippe E Garnier ◽  
Christine Marie ◽  
Alain Beley
Keyword(s):  
Cell Death ◽  
Cerebral Ischemia ◽  
Protective Effect ◽  
Apoptotic Cell ◽  
Focal Cerebral Ischemia ◽  
Iron Chelator ◽  
Apoptotic Cell Death

KIOM-79 prevents apoptotic cell death and AGEs accumulation in the retina of diabetic db/db mice

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
YS Kim ◽  
EJ Sohn ◽  
HY Lee ◽  
CS Kim ◽  
YM Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death
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