Modulation of the Protein Kinase CK2 Activity by a Synthetic Peptide Corresponding to the N-Terminus of Its β Regulatory Subunit

1997 ◽  
Vol 232 (1) ◽  
pp. 178-182 ◽  
Author(s):  
Emmanuelle Valero ◽  
Edmond M. Chambaz ◽  
Claude Cochet
Keyword(s):  
Protein Kinase ◽  
Synthetic Peptide ◽  
Protein Kinase Ck2 ◽  
Regulatory Subunit ◽  
N Terminus ◽  
Kinase Ck2

Structure of the Human Protein Kinase CK2 Catalytic Subunit CK2α′ and Interaction Thermodynamics with the Regulatory Subunit CK2β

2011 ◽  
Vol 407 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Nils Bischoff ◽  
Birgitte Olsen ◽  
Jennifer Raaf ◽  
Maria Bretner ◽  
Olaf-Georg Issinger ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Catalytic Subunit ◽  
Human Protein ◽  
Regulatory Subunit ◽  
Human Protein Kinase ◽  
Kinase Ck2

scholarly journals The regulatory subunit of protein kinase CK2 is a specific A-Raf activator

FEBS Letters ◽  
1997 ◽  
Vol 403 (2) ◽  
pp. 200-202 ◽  
Author(s):  
Carsten Hagemann ◽  
Andreas Kalmes ◽  
Viktor Wixler ◽  
Ludmilla Wixler ◽  
Tillman Schuster ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Regulatory Subunit ◽  
Kinase Ck2

scholarly journals The protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cells

Oncogenesis ◽  
2019 ◽  
Vol 8 (11) ◽  
Author(s):  
Giovanni Di Maira ◽  
Alessandra Gentilini ◽  
Mirella Pastore ◽  
Alessandra Caligiuri ◽  
Benedetta Piombanti ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Molecular Mechanisms ◽  
Regulatory Subunit ◽  
Proliferative Potential ◽  
Malignant Phenotype ◽  
Invasion And Migration ◽  
Migration Potential ◽  
And Migration ◽  
Kinase Ck2

Abstract Cholangiocarcinoma (CCA) is a particularly aggressive hepatobiliary malignancy, for which the molecular mechanisms underlying the malignant phenotype are still poorly understood, and novel and effective therapeutic strategies are limited. The pro-survival protein kinase CK2 is frequently overexpressed in cancer and is receiving increasing interest as an anti-tumor drug target. Its precise role in CCA biology is still largely unknown. Here we show that expression of the CK2α and α’ catalytic subunits and of the β regulatory subunit is increased in human CCA samples. Increased expression of CK2 subunits was shown in CCA cell lines compared to non-transformed cholangiocytes. We used chemical inhibition of CK2 and genetic modification by CRISPR/Cas9 to explore the contribution of CK2 to the malignant phenotype of CCA cells. Disruption of CK2 activity results in cell death through apoptosis, reduced invasion and migration potential, and G0/G1 cell cycle arrest. Importantly, CCA cells with a reduced CK2 activity are more sensitive to chemotherapy. Altogether, our results demonstrate that CK2 significantly contributes to increased proliferative potential and augmented growth of CCA cells and indicate the rationale for its targeting as a promising pharmacologic strategy for cholangiocarcinoma.

scholarly journals Binding of Polyamines to an Autonomous Domain of the Regulatory Subunit of Protein Kinase CK2 Induces a Conformational Change in the Holoenzyme

1997 ◽  
Vol 272 (33) ◽  
pp. 20820-20827 ◽  
Author(s):  
Didier Leroy ◽  
Jean-Karim Heriché ◽  
Odile Filhol ◽  
Edmond M. Chambaz ◽  
Claude Cochet
Keyword(s):  
Protein Kinase ◽  
Conformational Change ◽  
Protein Kinase Ck2 ◽  
Regulatory Subunit ◽  
Kinase Ck2

scholarly journals Differential Phosphorylation of a Regulatory Subunit of Protein Kinase CK2 by Target of Rapamycin Complex 1 Signaling and the Cdc-like Kinase Kns1

2015 ◽  
Vol 290 (11) ◽  
pp. 7221-7233 ◽  
Author(s):  
Manuel E. Sanchez-Casalongue ◽  
Jaehoon Lee ◽  
Aviva Diamond ◽  
Scott Shuldiner ◽  
Robyn D. Moir ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Target Of Rapamycin ◽  
Regulatory Subunit ◽  
Kinase Ck2 ◽  
Differential Phosphorylation
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