Neutrophils, Monocytes, and Dendritic Cells Express the Same Specialized Form of PSGL-1 as Do Skin-Homing Memory T Cells: Cutaneous Lymphocyte Antigen

IgE/antigen-FcϵRI crosslinking promotes antigen internalization and apoptosis in mouse mast cells. Dendritic cells uptake the apoptotic mast cells carrying internalized antigens, and thus can efficiently present the antigens to memory T cells.

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Regulatory T cells limit unconventional memory to preserve the capacity to mount protective CD8 memory responses to pathogens

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1818327116 ◽

2019 ◽

Vol 116 (20) ◽

pp. 9969-9978 ◽

Cited By ~ 2

Author(s):

Andreia S. Da Costa ◽

Jessica B. Graham ◽

Jessica L. Swarts ◽

Jennifer M. Lund

Keyword(s):

T Cells ◽

Dendritic Cells ◽

Regulatory T Cells ◽

Cd8 T Cells ◽

Regulatory T Cell ◽

Memory T Cells ◽

Virtual Memory ◽

Cd8 T Lymphocytes ◽

Pathogen Control ◽

Cognate Antigen

Immunological memory exists so that following infection an expanded population of pathogen-specific lymphocytes can rapidly and efficiently control infection in the case of reexposure. However, in the case of CD8+ T lymphocytes, a population of unconventional CD44+CD122+ virtual memory T cells (TVM) has been described that possesses many, though not all, features of “true memory” T cells, without the requirement of first encountering cognate antigen. Here, we demonstrate a role for regulatory T cell-mediated restraint of TVM at least in part through limiting IL-15 trans-presentation by CD11b+ dendritic cells. Further, we show that keeping TVM in check ensures development of functional, antigen-specific “true” memory phenotype CD8+ T cells that can assist in pathogen control upon reexposure.

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035 CD4+ resident memory T cells colocalize with CD301b+ dendritic cells in perifollicular lymphocyte clusters in a murine delayed-type hypersensitivity model

Journal of Investigative Dermatology ◽

10.1016/j.jid.2019.07.038 ◽

2019 ◽

Vol 139 (9) ◽

pp. S220

Author(s):

R. Asahina ◽

G. Egawa ◽

K. Kabashima

Keyword(s):

T Cells ◽

Dendritic Cells ◽

Memory T Cells ◽

Delayed Type Hypersensitivity ◽

Resident Memory T Cells

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IL-6 Production by Dendritic Cells Is Dispensable for CD8+Memory T-Cell Generation

BioMed Research International ◽

10.1155/2013/126189 ◽

2013 ◽

Vol 2013 ◽

pp. 1-12 ◽

Cited By ~ 6

Author(s):

Jean-François Daudelin ◽

Mélissa Mathieu ◽

Salix Boulet ◽

Nathalie Labrecque

Keyword(s):

T Cells ◽

Dendritic Cells ◽

T Cell ◽

B Cell ◽

Memory T Cells ◽

T Cell Memory ◽

Memory Cells ◽

Differential Outcome ◽

Memory T Cell ◽

Antigen Presenting

Following activation, naïve CD8+T cells will differentiate into effectors that differ in their ability to survive: some will persist as memory cells while the majority will die by apoptosis. Signals given by antigen-presenting cells (APCs) at the time of priming modulate this differential outcome. We have recently shown that, in opposition to dendritic cell (DC), CD40-activated B-(CD40-B) cell vaccination fails to efficiently produce CD8+memory T cells. Understanding why CD40-B-cell vaccination does not lead to the generation of functional long-lived memory cells is essential to define the signals that should be provided to naïve T cells by APCs. Here we show that CD40-B cells produce very low amount of IL-6 when compared to DCs. However, supplementation with IL-6 during CD40-B-cell vaccination did not improve memory generation. Furthermore, IL-6-deficient DCs maintained the capacity to promote the formation of functional CD8+effectors and memory cells. Our results suggest that in APC vaccination models, IL-6 provided by the APCs is dispensable for proper CD8+T-cell memory generation.

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Innate Immune Responses to Herpes Simplex Virus Type 2 Influence Skin Homing Molecule Expression by Memory CD4+ Lymphocytes

Journal of Virology ◽

10.1128/jvi.80.6.2863-2872.2006 ◽

2006 ◽

Vol 80 (6) ◽

pp. 2863-2872 ◽

Cited By ~ 12

Author(s):

David M. Koelle ◽

Jay Huang ◽

Michael T. Hensel ◽

Christopher L. McClurkan

Keyword(s):

T Cells ◽

Dendritic Cells ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Cd4 T Cells ◽

Receptor Expression ◽

Homing Receptor ◽

Skin Homing ◽

Simplex Virus

ABSTRACT Herpes simplex virus (HSV) infections of humans are characterized by intermittent, lytic replication in epithelia. Circulating HSV-specific CD4 T cells express lower levels of preformed cutaneous lymphocyte-associated antigen (CLA), a skin-homing receptor, than do circulating HSV-specific CD8 T cells but, paradoxically, move into infected skin earlier than CD8 cells. Memory CD4 T cells develop strong and selective expression of CLA and E-selectin ligand while responding to HSV antigen in vitro. We now show that interleukin-12, type I interferon, and transforming growth factor beta are each involved in CLA expression by memory HSV type 2 (HSV-2)-specific CD4 T cells in peripheral blood mononuclear cells (PBMC). A reduction of the number of monocytes and dendritic cells from PBMC reduces CLA expression by HSV-2-responsive CD4 lymphoblasts, while their reintroduction restores this phenotype, identifying these cells as possible sources of CLA-promoting cytokines. Plasmacytoid dendritic cells are particularly potent inducers of CLA on HSV-reactive CD4 T cells. These observations are consistent with cooperation between innate and acquired immunity to promote a pattern of homing receptor expression that is physiologically appropriate for trafficking to infected tissues.

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