scholarly journals Role of Galectin-1 in the Developing Mouse Olfactory System

1996 ◽  
Vol 179 (1) ◽  
pp. 274-287 ◽  
Author(s):  
A.C. Puche ◽  
F. Poirier ◽  
M. Hair ◽  
P.F. Bartlett ◽  
B. Key
Keyword(s):  
Olfactory System

Early deficits in olfaction are associated with structural and molecular alterations in the olfactory system of a Huntington disease mouse model

2020 ◽  
Vol 29 (13) ◽  
pp. 2134-2147
Author(s):  
M Laroche ◽  
M Lessard-Beaudoin ◽  
M Garcia-Miralles ◽  
C Kreidy ◽  
E Peachey ◽  
...  
Keyword(s):  
Huntington Disease ◽  
Olfactory System ◽  
Piriform Cortex ◽  
Olfactory Dysfunction ◽  
Altered Expression ◽  
Neuronal Nuclei ◽  
Molecular Alterations ◽  
Cell Death Pathways ◽  
Structural Abnormalities

Abstract Olfactory dysfunction and altered neurogenesis are observed in several neurodegenerative disorders including Huntington disease (HD). These deficits occur early and correlate with a decline in global cognitive performance, depression and structural abnormalities of the olfactory system including the olfactory epithelium, bulb and cortices. However, the role of olfactory system dysfunction in the pathogenesis of HD remains poorly understood and the mechanisms underlying this dysfunction are unknown. We show that deficits in odour identification, discrimination and memory occur in HD individuals. Assessment of the olfactory system in an HD murine model demonstrates structural abnormalities in the olfactory bulb (OB) and piriform cortex, the primary cortical recipient of OB projections. Furthermore, a decrease in piriform neuronal counts and altered expression levels of neuronal nuclei and tyrosine hydroxylase in the OB are observed in the YAC128 HD model. Similar to the human HD condition, olfactory dysfunction is an early phenotype in the YAC128 mice and concurrent with caspase activation in the murine HD OB. These data provide a link between the structural olfactory brain region atrophy and olfactory dysfunction in HD and suggest that cell proliferation and cell death pathways are compromised and may contribute to the olfactory deficits in HD.

scholarly journals The role of SNMPs in insect olfaction

2020 ◽  
Author(s):  
Sina Cassau ◽  
Jürgen Krieger
Keyword(s):  
Membrane Proteins ◽  
Olfactory System ◽  
Critical Role ◽  
Olfactory Receptors ◽  
Wide Distribution ◽  
Insect Olfaction ◽  
Survival And Reproduction ◽  
Odorant Binding ◽  
Encoding Genes

AbstractThe sense of smell enables insects to recognize olfactory signals crucial for survival and reproduction. In insects, odorant detection highly depends on the interplay of distinct proteins expressed by specialized olfactory sensory neurons (OSNs) and associated support cells which are housed together in chemosensory units, named sensilla, mainly located on the antenna. Besides odorant-binding proteins (OBPs) and olfactory receptors, so-called sensory neuron membrane proteins (SNMPs) are indicated to play a critical role in the detection of certain odorants. SNMPs are insect-specific membrane proteins initially identified in pheromone-sensitive OSNs of Lepidoptera and are indispensable for a proper detection of pheromones. In the last decades, genome and transcriptome analyses have revealed a wide distribution of SNMP-encoding genes in holometabolous and hemimetabolous insects, with a given species expressing multiple subtypes in distinct cells of the olfactory system. Besides SNMPs having a neuronal expression in subpopulations of OSNs, certain SNMP types were found expressed in OSN-associated support cells suggesting different decisive roles of SNMPs in the peripheral olfactory system. In this review, we will report the state of knowledge of neuronal and non-neuronal members of the SNMP family and discuss their possible functions in insect olfaction.

scholarly journals Role of a transcription factor Pax6 in the developing vertebrate olfactory system

2007 ◽  
Vol 49 (9) ◽  
pp. 683-690 ◽  
Author(s):  
Tadashi Nomura ◽  
Hasumi Haba ◽  
Noriko Osumi
Keyword(s):  
Transcription Factor ◽  
Olfactory System

scholarly journals The Role of the Terminal Nerve and GnRH in Olfactory System Neuromodulation

2009 ◽  
Vol 26 (10) ◽  
pp. 669-680 ◽  
Author(s):  
Takafumi Kawai ◽  
Yoshitaka Oka ◽  
Heather Eisthen
Keyword(s):  
Olfactory System ◽  
Terminal Nerve

scholarly journals An Investigation on the Role of Spike Latency in an Artificial Olfactory System

2011 ◽  
Vol 4 ◽  
Author(s):  
Eugenio Martinelli ◽  
Davide Polese ◽  
Francesca Dini ◽  
Roberto Paolesse ◽  
Daniel Filippini ◽  
...  
Keyword(s):  
Olfactory System ◽  
Spike Latency

scholarly journals Critical Role of GFR 1 in the Development and Function of the Main Olfactory System

2012 ◽  
Vol 32 (48) ◽  
pp. 17306-17320 ◽  
Author(s):  
C. Marks ◽  
L. Belluscio ◽  
C. F. Ibanez
Keyword(s):  
Olfactory System ◽  
Critical Role ◽  
And Function ◽  
Main Olfactory System

scholarly journals COVID-19 Pulmonary and Olfactory Dysfunctions: Is the Chemokine CXCL10 the Common Denominator?

2020 ◽  
pp. 107385842093903 ◽  
Author(s):  
Antonio Oliviero ◽  
Fernando de Castro ◽  
Francesca Coperchini ◽  
Luca Chiovato ◽  
Mario Rotondi
Keyword(s):  
Olfactory System ◽  
Distress Syndrome ◽  
Present Report ◽  
Subsequent Development ◽  
Common Denominator ◽  
The World ◽  
The Common ◽  
Established Role ◽  
Physiological Peculiarity

COVID-19 is an ongoing viral pandemic that emerged from East Asia and quickly spread to the rest of the world. SARS-CoV-2 is the virus causing COVID-19. Acute respiratory distress syndrome (ARDS) is definitely one of the main clinically relevant consequences in patients with COVID-19. Starting from the earliest reports of the COVID-19 pandemic, two peculiar neurological manifestations (namely, hyposmia/anosmia and dysgeusia) were reported in a relevant proportion of patients infected by SARS-CoV-2. At present, the physiopathologic mechanisms accounting for the onset of these symptoms are not yet clarified. CXCL10 is a pro-inflammatory chemokine with a well-established role in the COVID-19-related cytokine storm and in subsequent development of ARDS. CXCL10 is also known to be involved in coronavirus-induced demyelination. On these bases, a role for CXCL10 as the common denominator between pulmonary and olfactory dysfunctions could be envisaged. The aim of the present report will be to hypothesize a role for CXCL10 in COVID-19 olfactory dysfunctions. Previous evidences supporting our hypothesis, with special emphasis to the role of CXCL10 in coronavirus-induced demyelination, the anatomical and physiological peculiarity of the olfactory system, and the available data supporting their link during COVID-19 infections, will be overviewed.

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