scholarly journals The Role of the Ets Domain Transcription Factor Erm in Modulating Differentiation of Neural Crest Stem Cells

2002 ◽  
Vol 250 (1) ◽  
pp. 168-180 ◽  
Author(s):  
Christian Paratore ◽  
Guya Brugnoli ◽  
Hye-Youn Lee ◽  
Ueli Suter ◽  
Lukas Sommer
Keyword(s):  
Stem Cells ◽  
Transcription Factor ◽  
Neural Crest ◽  
Neural Crest Stem Cells ◽  
Ets Domain

scholarly journals Lineage-specific requirements of β-catenin in neural crest development

2002 ◽  
Vol 159 (5) ◽  
pp. 867-880 ◽  
Author(s):  
Lisette Hari ◽  
Véronique Brault ◽  
Maurice Kléber ◽  
Hye-Youn Lee ◽  
Fabian Ille ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Neural Crest ◽  
Neural Crest Cells ◽  
Neural Crest Stem Cells ◽  
Downstream Signaling ◽  
Neural Crest Development ◽  
Sensory Neurogenesis

β-Catenin plays a pivotal role in cadherin-mediated cell adhesion. Moreover, it is a downstream signaling component of Wnt that controls multiple developmental processes such as cell proliferation, apoptosis, and fate decisions. To study the role of β-catenin in neural crest development, we used the Cre/loxP system to ablate β-catenin specifically in neural crest stem cells. Although several neural crest–derived structures develop normally, mutant animals lack melanocytes and dorsal root ganglia (DRG). In vivo and in vitro analyses revealed that mutant neural crest cells emigrate but fail to generate an early wave of sensory neurogenesis that is normally marked by the transcription factor neurogenin (ngn) 2. This indicates a role of β-catenin in premigratory or early migratory neural crest and points to heterogeneity of neural crest cells at the earliest stages of crest development. In addition, migratory neural crest cells lateral to the neural tube do not aggregate to form DRG and are unable to produce a later wave of sensory neurogenesis usually marked by the transcription factor ngn1. We propose that the requirement of β-catenin for the specification of melanocytes and sensory neuronal lineages reflects roles of β-catenin both in Wnt signaling and in mediating cell–cell interactions.

Instructive Role of Wnt/ -Catenin in Sensory Fate Specification in Neural Crest Stem Cells

Science ◽  
2004 ◽  
Vol 303 (5660) ◽  
pp. 1020-1023 ◽  
Author(s):  
H.-Y. Lee
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Neural Crest Stem Cells ◽  
Fate Specification

Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling

Development ◽  
2001 ◽  
Vol 128 (20) ◽  
pp. 3949-3961 ◽  
Author(s):  
Christian Paratore ◽  
Derk E. Goerich ◽  
Ueli Suter ◽  
Michael Wegner ◽  
Lukas Sommer
Keyword(s):  
Stem Cells ◽  
Transcription Factor ◽  
Neural Crest ◽  
Hirschsprung Disease ◽  
Neural Crest Cells ◽  
Fine Tuning ◽  
Enteric Neurons ◽  
Dependent Manner ◽  
Neural Crest Stem Cells ◽  
Glial Fate

The transcription factor Sox10 is required for proper development of various neural crest-derived cell types. Several lineages including melanocytes, autonomic and enteric neurons, and all subtypes of peripheral glia are missing in mice homozygous for Sox10 mutations. Moreover, haploinsufficiency of Sox10 results in neural crest defects that cause Waardenburg/Hirschsprung disease in humans. We provide evidence that the cellular basis to these phenotypes is likely to be a requirement for Sox10 by neural crest stem cells before lineage segregation. Cell death is increased in undifferentiated, postmigratory neural crest cells that lack Sox10, suggesting a role of Sox10 in the survival of neural crest cells. This function is mediated by neuregulin, which acts as a survival signal for postmigratory neural crest cells in a Sox10-dependent manner. Furthermore, Sox10 is required for glial fate acquisition, as the surviving mutant neural crest cells are unable to adopt a glial fate when challenged with different gliogenic conditions. In Sox10 heterozygous mutant neural crest cells, survival appears to be normal, while fate specifications are drastically affected. Thereby, the fate chosen by a mutant neural crest cell is context dependent. Our data indicate that combinatorial signaling by Sox10, extracellular factors such as neuregulin 1, and local cell-cell interactions is involved in fine-tuning lineage decisions by neural crest stem cells. Failures in fate decision processes might thus contribute to the etiology of Waardenburg/Hirschsprung disease.

scholarly journals Comparative Craniofacial Bone Regeneration Capacities of Mesenchymal Stem Cells Derived from Human Neural Crest Stem Cells and Bone Marrow

2020 ◽  
Author(s):  
Akshaya Srinivasan ◽  
Nelson Teo ◽  
Kei Jun Poon ◽  
Priya Tiwari ◽  
Akhilandeshwari Ravichandran ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Neural Crest ◽  
Bone Regeneration ◽  
Neural Crest Stem Cells ◽  
Craniofacial Bone

scholarly journals Fine‐tuning of dual‐SMAD inhibition to differentiate human pluripotent stem cells into neural crest stem cells

2021 ◽  
Author(s):  
Hyun‐Mun Kim ◽  
Hye Bin Noh ◽  
Sang‐Hyuk Lee ◽  
Kun‐Gu Lee ◽  
Bomi Chang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Pluripotent Stem Cells ◽  
Human Pluripotent Stem Cells ◽  
Fine Tuning ◽  
Neural Crest Stem Cells

scholarly journals Editor’s Note: Adult bone marrow mesenchymal and neural crest stem cells are chemoattractive and accelerate motor recovery in a mouse model of spinal cord injury

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Virginie Neirinckx ◽  
Gulistan Agirman ◽  
Cécile Coste ◽  
Alice Marquet ◽  
Valérie Dion ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Mouse Model ◽  
Neural Crest ◽  
Neural Crest Stem Cells ◽  
Adult Bone Marrow ◽  
Cord Injury ◽  
Adult Bone
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