Heparin Modulates the Receptor-Binding and Mitogenic Activity of Hepatocyte Growth Factor on Hepatocytes

1993 ◽  
Vol 209 (2) ◽  
pp. 317-324 ◽  
Author(s):  
Daiji Naka ◽  
Takehisa Ishii ◽  
Takeshi Shimomura ◽  
Tadashi Hishida ◽  
Hiroto Hara
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Receptor Binding ◽  
Mitogenic Activity ◽  
Hepatocyte Growth

scholarly journals Dissociation of Heparan Sulfate and Receptor Binding Domains of Hepatocyte Growth Factor Reveals That Heparan Sulfate-c-Met Interaction Facilitates Signaling

2001 ◽  
Vol 276 (35) ◽  
pp. 32977-32983 ◽  
Author(s):  
Jeffrey S. Rubin ◽  
Regina M. Day ◽  
Diane Breckenridge ◽  
Nese Atabey ◽  
William G. Taylor ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Heparan Sulfate ◽  
Receptor Binding ◽  
Binding Domains ◽  
Hepatocyte Growth

Hepatocyte growth factor is a mitogen for alveolar type II cells in rat lavage fluid

1996 ◽  
Vol 271 (1) ◽  
pp. L46-L53 ◽  
Author(s):  
R. J. Mason ◽  
K. McCormick-Shannon ◽  
J. S. Rubin ◽  
T. Nakamura ◽  
C. C. Leslie
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Lavage Fluid ◽  
Mitogenic Activity ◽  
Alveolar Type ◽  
Type Ii Cells ◽  
Type Ii ◽  
Hepatocyte Growth

Proliferation of type II cells is required for maintenance of the alveolar epithelium and for restoration after lung injury. Although various known growth factors have been reported to stimulate type II cell proliferation in vitro, there is very little knowledge on which growth factors are present in the lung in vivo. We have previously reported that rat lavage fluid contains a mitogen(s) for type II cells, and this study was de signed to identify the growth factor(s) in this biological fluid for type II cells. The mitogenic activity was purified by sequential chromatography on blue Sepharose and heparin Sepharose. Hepatocyte growth factor (HGF) and acidic fibroblast growth factor by Western analysis. The amount of HGF recovered by lavage was approximately 6 ng/rat. By a use of neutralizing antibodies for different growth factors, HGF was found to be responsible for most of the stimulatory activity for rat type II cells in the partially purified lavage fluid. In addition to HGF, rat lavage fluid also contained potent mitogenic activity for fibroblasts. Finally, we have demonstrated that much of the mitogenic activity in salt extracts of human lung is HGF. We conclude that HGF is found in rat lavage fluid and is possibly an important mitogen for adult type II cells in vivo.

scholarly journals Sulfated Oligosaccharides Promote Hepatocyte Growth Factor Association and Govern Its Mitogenic Activity

1995 ◽  
Vol 270 (28) ◽  
pp. 16871-16878 ◽  
Author(s):  
Thomas F. Zioncheck ◽  
Louise Richardson ◽  
Jun Liu ◽  
Ling Chang ◽  
Kathleen L. King ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Mitogenic Activity ◽  
Sulfated Oligosaccharides ◽  
Hepatocyte Growth

Role of Bcl-xL in hepatocyte growth factor-elicited epithelial protection in idiopathic pulmonary fibrosis

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
S Skwarna ◽  
I Henneke ◽  
W Seeger ◽  
T Geiser ◽  
A Günther ◽  
...  
Keyword(s):  
Growth Factor ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Hepatocyte Growth Factor ◽  
Hepatocyte Growth
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