Growth Hormone-Releasing Hormone Immunoreactivity in the Brain, Pituitary, and Pineal of the Goldfish,Carassius auratus

1996 ◽  
Vol 102 (2) ◽  
pp. 210-220 ◽  
Author(s):  
Sandhya D. Rao ◽  
P.D. Prasada Rao ◽  
Richard E. Peter
Keyword(s):  
Growth Hormone ◽  
Carassius Auratus ◽  
Growth Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Goldfish Carassius Auratus ◽  
The Brain

GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity

2020 ◽  
Vol 52 (05) ◽  
pp. 336-339 ◽  
Author(s):  
Nektarios Barabutis ◽  
Mohammad S. Akhter ◽  
Mohammad A. Uddin ◽  
Khadeja-Tul Kubra ◽  
Andrew V. Schally
Keyword(s):  
Growth Hormone ◽  
Anticancer Agents ◽  
Growth Hormone Releasing Hormone ◽  
Barrier Dysfunction ◽  
Microvascular Endothelium ◽  
Releasing Hormone ◽  
Ghrh Antagonists ◽  
Hormone Antagonists ◽  
The Brain

AbstractGrowth hormone releasing hormone is a hypothalamic neuropeptide, which regulates the release of growth hormone from the anterior pituitary gland. Growth hormone releasing hormone antagonists are anticancer agents, associated with strong anti-inflammatory activities. In the present study, we investigated the effects of the GHRH antagonist MIA-602 in the integrity of the brain microvascular endothelium in vitro. Our observations suggest that MIA-602 protects against the H2O2-induced breakdown of the brain endothelium and enhances its integrity by inducing P53, deactivating cofilin, and suppressing the RhoA inflammatory pathway. Thus, GHRH antagonists may offer an exciting possibility for the treatment of pathologies related to the blood brain barrier dysfunction, including the Parkinson’s and Alzheimer’s diseases.

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