Modulation of glycophorin A transmembrane helix interactions by lipid bilayers: molecular dynamics calculations

2000 ◽  
Vol 302 (3) ◽  
pp. 727-746 ◽  
Author(s):  
Horia I Petrache ◽  
Alan Grossfield ◽  
Kevin R MacKenzie ◽  
Donald M Engelman ◽  
Thomas B Woolf
Keyword(s):  
Molecular Dynamics ◽  
Lipid Bilayers ◽  
Transmembrane Helix ◽  
Glycophorin A ◽  
Molecular Dynamics Calculations ◽  
Helix Interactions

Transmembrane Helix−Helix Interactions:  Comparative Simulations of the Glycophorin A Dimer†

Biochemistry ◽  
2006 ◽  
Vol 45 (48) ◽  
pp. 14298-14310 ◽  
Author(s):  
Jonathan M. Cuthbertson ◽  
Peter J. Bond ◽  
Mark S. P. Sansom
Keyword(s):  
Transmembrane Helix ◽  
Glycophorin A ◽  
Helix Interactions

Effect of Integral Proteins on Frozen Membrane Fracture

1980 ◽  
Vol 38 ◽  
pp. 756-759 ◽  
Author(s):  
S. Kirchanski ◽  
D. Branton
Keyword(s):  
Lipid Bilayers ◽  
Freeze Fracture ◽  
Covalent Bond ◽  
Erythrocyte Membranes ◽  
Glycophorin A ◽  
Experimental Protocol ◽  
Transmembrane Glycoprotein ◽  
Bond Breakage ◽  
Human Erythrocyte Membranes ◽  
Integral Proteins

We have investigated the effect of integral membrane proteins upon the fracturing of frozen lipid bilayers. This investigation has been part of an effort to develop freeze fracture labeling techniques and to assess the possible breakage of covalent protein bonds during the freeze fracture process. We have developed an experimental protocol utilizing lectin affinity columns which should detect small amounts of covalent bond breakage during the fracture of liposomes containing purified (1) glycophorin (a transmembrane glycoprotein of human erythrocyte membranes). To fracture liposomes in bulk, frozen liposomes are ground repeatedly under liquid nitrogen. Failure to detect any significant covalent bond breakage (contrary to (2)) led us to question the effectiveness of our grinding procedure in fracturing and splitting lipid bilayers.

MOLECULAR DYNAMICS CALCULATIONS OF NEAR-CRITICAL LIQUID OXYGEN DROPLET SURFACE TENSION

2005 ◽  
Vol 15 (4) ◽  
pp. 413-422 ◽  
Author(s):  
Michael M. Micci ◽  
S. J. Lee ◽  
B. Vieille ◽  
C. Chauveau ◽  
Iskendar Gokalp
Keyword(s):  
Molecular Dynamics ◽  
Surface Tension ◽  
Droplet Surface ◽  
Liquid Oxygen ◽  
Molecular Dynamics Calculations
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