scholarly journals Non-immunogenic Murine Hepatocellular Carcinoma Hepa1-6 Cells Expressing the Membrane Form of Macrophage Colony Stimulating Factor Are Rejected in Vivo and Lead to CD8+ T-Cell Immunity Against the Parental Tumor

2001 ◽  
Vol 4 (5) ◽  
pp. 427-437 ◽  
Author(s):  
Qinghong Dan ◽  
Ramon Sanchez ◽  
Christina Delgado ◽  
H.Terry Wepsic ◽  
Kengathevy Morgan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Colony Stimulating Factor ◽  
Cell Immunity ◽  
Macrophage Colony Stimulating Factor ◽  
Parental Tumor ◽  
Macrophage Colony ◽  
Stimulating Factor

Generation of T-Cell Immunity to the HER-2/neu Protein After Active Immunization With HER-2/neu Peptide–Based Vaccines

2002 ◽  
Vol 20 (11) ◽  
pp. 2624-2632 ◽  
Author(s):  
Mary L. Disis ◽  
Theodore A. Gooley ◽  
Kristine Rinn ◽  
Donna Davis ◽  
Michael Piepkorn ◽  
...  
Keyword(s):  
T Cell ◽  
Stimulation Index ◽  
T Cell Immunity ◽  
Colony Stimulating Factor ◽  
Epitope Spreading ◽  
Cell Immunity ◽  
Her 2 ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

PURPOSE: The HER-2/neu protein is a nonmutated tumor antigen that is overexpressed in a variety of human malignancies, including breast and ovarian cancer. Many tumor antigens, such as MAGE and gp100, are self-proteins; therefore, effective vaccine strategies must circumvent tolerance. We hypothesized that immunizing patients with subdominant peptide epitopes derived from HER-2/neu, using an adjuvant known to recruit professional antigen-presenting cells, granulocyte-macrophage colony-stimulating factor, would result in the generation of T-cell immunity specific for the HER-2/neu protein. PATIENTS AND METHODS: Sixty-four patients with HER-2/neu–overexpressing breast, ovarian, or non–small-cell lung cancers were enrolled. Vaccines were composed of peptides derived from potential T-helper epitopes of the HER-2/neu protein admixed with granulocyte-macrophage colony-stimulating factor and administered intradermally. Peripheral-blood mononuclear cells were evaluated at baseline, before vaccination, and after vaccination for antigen-specific T-cell immunity. Immunologic response data are presented on the 38 subjects who completed six vaccinations. Toxicity data are presented on all 64 patients enrolled. RESULTS: Ninety-two percent of patients developed T-cell immunity to HER-2/neu peptides (stimulation index, 2.1 to 59) and 68% to a HER-2/neu protein domain (stimulation index range, 2 to 31). Epitope spreading was observed in 84% of patients and significantly correlated with the generation of a HER-2/neu protein–specific T-cell immunity (P = .03). At 1-year follow-up, immunity to the HER-2/neu protein persisted in 38% of patients. CONCLUSION: The majority of patients with HER-2/neu–overexpressing cancers can develop immunity to both HER-2/neu peptides and protein. In addition, the generation of protein-specific immunity, after peptide immunization, was associated with epitope spreading, reflecting the initiation of an endogenous immune response. Finally, immunity can persist after active immunizations have ended.

scholarly journals Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

Cancer Cell ◽  
2012 ◽  
Vol 21 (6) ◽  
pp. 822-835 ◽  
Author(s):  
Lauren J. Bayne ◽  
Gregory L. Beatty ◽  
Nirag Jhala ◽  
Carolyn E. Clark ◽  
Andrew D. Rhim ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
T Cell ◽  
T Cell Immunity ◽  
Colony Stimulating Factor ◽  
Cell Immunity ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

In vivo effects of macrophage colony-stimulating factor on human monocyte function

1991 ◽  
Vol 77 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Asim Khwaja ◽  
Beryl Johnson ◽  
Ian E. Addison ◽  
Kwee Yong ◽  
Karen Ruthven ◽  
...  
Keyword(s):  
Human Monocyte ◽  
Colony Stimulating Factor ◽  
Monocyte Function ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
In Vivo Effects ◽  
Stimulating Factor

Granulocyte-macrophage colony-stimulating factor (GM-CSF) increases plasma fibrinolytic activity in vivo

1994 ◽  
Vol 8 (1) ◽  
pp. 42-47 ◽  
Author(s):  
K.L. Yong ◽  
T. McNally ◽  
I.J. Mackie ◽  
H. Cohen ◽  
S.J. Machin ◽  
...  
Keyword(s):  
Fibrinolytic Activity ◽  
Colony Stimulating Factor ◽  
Gm Csf ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor
Sign in / Sign up

Export Citation Format

Share Document