Role of the Scavenger Receptor Class B Type I in Lipoprotein Metabolism and Atherosclerosis: Insight from Genetically Altered Mice

2006 ◽  
pp. 53-69 ◽  
Author(s):  
Bernardo Trigatti
Keyword(s):  
Scavenger Receptor ◽  
Lipoprotein Metabolism ◽  
Type I ◽  
Scavenger Receptor Class ◽  
Class B

The Role of Human and Mouse Hepatic Scavenger Receptor Class B Type I (SR-BI) in the Selective Uptake of Low-Density Lipoprotein−Cholesteryl Esters†

Biochemistry ◽  
2003 ◽  
Vol 42 (24) ◽  
pp. 7527-7538 ◽  
Author(s):  
David Rhainds ◽  
Mathieu Brodeur ◽  
Jany Lapointe ◽  
Daniel Charpentier ◽  
Louise Falstrault ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Type I ◽  
Low Density ◽  
Cholesteryl Esters ◽  
Scavenger Receptor Class ◽  
Class B ◽  
Human And Mouse

Scavenger receptor class B type I in high-density lipoprotein metabolism, atherosclerosis and heart disease: lessons from gene-targeted mice

2004 ◽  
Vol 32 (1) ◽  
pp. 116-120 ◽  
Author(s):  
B. Trigatti ◽  
S. Covey ◽  
A. Rizvi
Keyword(s):  
Bone Marrow ◽  
Heart Disease ◽  
Knockout Mice ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Type I ◽  
Scavenger Receptor Class ◽  
Class B

The scavenger receptor class B type I (SR-BI) is a multi-ligand receptor that can mediate the binding and bi-directional lipid transfer between high-density lipoproteins (HDLs) and cells. It is expressed in a variety of tissues, including the liver, and in macrophages in atherosclerotic plaques. The physiological role of SR-BI has been tested in vivo by the genetic manipulation of SR-BI levels in mice. Mice lacking SR-BI exhibit impaired hepatic-selective HDL cholesterol uptake and increased atherosclerosis, suggesting that SR-BI is required for hepatic reverse cholesterol transport and normally protects against atherosclerosis. Surprisingly, elimination of SR-BI in apolipoprotein E knockout mice results in rapid development of occlusive coronary artery disease, accompanied by spontaneous myocardial infarction, reduced heart function and early death, which points to a role for SR-BI in protection against coronary heart disease. The in vivo role of macrophage SR-BI has been less clear. We have used bone-marrow transplantation to demonstrate that bone-marrow-derived SR-BI also normally protects against atherosclerosis in low-density lipoprotein receptor knockout mice. These results suggest that SR-BI may have multiple protective effects against atherosclerosis in different tissues.

Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: Role of CD81 and scavenger receptor class B type I and effect of antiviral drugs

Hepatology ◽  
2008 ◽  
Vol 49 (2) ◽  
pp. 364-377 ◽  
Author(s):  
Judith M. Gottwein ◽  
Troels K. H. Scheel ◽  
Tanja B. Jensen ◽  
Jacob B. Lademann ◽  
Jannick C. Prentoe ◽  
...  
Keyword(s):  
Cell Culture ◽  
Scavenger Receptor ◽  
Type I ◽  
Genotype 1 ◽  
Virus Genotype ◽  
Scavenger Receptor Class ◽  
Cell Culture Systems ◽  
Class B
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