Systems Approaches in Development Work

The Kafr El Sheikh Water Supply Project is a comprehensive endeavour to provide the physical and institutional resources for an effective and sustainable water supply system for 2 million persons in a developing rural Governorate in the Delta region of Egypt. The paper describes the aims of the Management Component, the institutional development of an integrated water supply and sewerage company and the main activities to-date. These include training, operational improvements, health education and finance development. Further support is required until all engineering and institutional development work has been completed.

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Risk-Informed Safety Margin Characterization Methods Development Work

10.2172/1169248 ◽

2014 ◽

Author(s):

Curtis L Smith ◽

Zhegang Ma ◽

Tom Riley ◽

Diego Mandelli ◽

Joseph W Nielsen ◽

...

Keyword(s):

Safety Margin ◽

Development Work ◽

Characterization Methods ◽

Methods Development

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Identification of Antineoplastic Targets with Systems Approaches, Using Resveratrol as an In-Depth Case Study

Current Pharmaceutical Design ◽

10.2174/1381612823666170710152918 ◽

2017 ◽

Vol 23 (32) ◽

pp. 4773-4793 ◽

Cited By ~ 5

Author(s):

Nivedita Singh ◽

Sherry Freiesleben ◽

Olaf Wolkenhauer ◽

Yogeshwer Shukla ◽

Shailendra K. Gupta

Keyword(s):

Drug Target ◽

Complex Disease ◽

Biological Targets ◽

Systems Approaches ◽

Anticancer Mechanism ◽

Genetic And Environmental Factors ◽

Key Steps ◽

Network Approaches ◽

Novel Drug

The identification and validation of novel drug–target combinations are key steps in the drug discovery processes. Cancer is a complex disease that involves several genetic and environmental factors. High-throughput omics technologies are now widely available, however the integration of multi-omics data to identify viable anticancer drug-target combinations, that allow for a better clinical outcome when considering the efficacy-toxicity spectrum, is challenging. This review article provides an overview of systems approaches which help to integrate a broad spectrum of technologies and data. We focus on network approaches and investigate anticancer mechanism and biological targets of resveratrol using reverse pharmacophore mapping as an in-depth case study. The results of this case study demonstrate the use of systems approaches for a better understanding of the behavior of small molecule inhibitors in receptor binding sites. The presented network analysis approach helps in formulating hypotheses and provides mechanistic insights of resveratrol in neoplastic transformations.

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