Comparison of inverted terrain processing implemented in this study to TopoToolbox results for interfluve (ridge-line) extraction and hierarchical ordering. Different topographic curvature metrics are also explored at varying raster resolutions across hillshed orders.
Comparison of inverted terrain processing implemented in this study to TopoToolbox results for interfluve (ridge-line) extraction and hierarchical ordering. Different topographic curvature metrics are also explored at varying raster resolutions across hillshed orders.
A new, continuous-flow consecutive reduction method was developed for the C-N bond formation in the synthesis of the key intermediate of the antipsychotic drug cariprazine. The two-step procedure consists of a DIBAL-H mediated selective ester reduction conducted in a novel, miniature alternating diameter reactor, followed by reductive amination using catalytic hydrogenation on 5% Pt/C. The connection of the optimized modules was accomplished using an at-line extraction to prevent precipitation of the aluminum salt byproducts.
Supplemental Material: Quantitative analysis of hillshed geomorphology and critical zone function: Raising the hillshed to watershed status
