Fault-Tolerance in Biochemical Systems

Author(s):  
Erik Winfree
1999 ◽  
Vol 37 (1) ◽  
pp. 11-17 ◽  
Author(s):  
A. PAUGAM ◽  
M. BENCHETRIT ◽  
A. FIACRE ◽  
C. TOURTE-SCHAEFER ◽  
J. DUPOUY-CAMET

Author(s):  
M. Chaitanya ◽  
K. Durga Charan

Load balancing makes cloud computing greater knowledgeable and could increase client pleasure. At reward cloud computing is among the all most systems which offer garage of expertise in very lowers charge and available all the time over the net. However, it has extra vital hassle like security, load administration and fault tolerance. Load balancing inside the cloud computing surroundings has a large impact at the presentation. The set of regulations relates the sport idea to the load balancing manner to amplify the abilties in the public cloud environment. This textual content pronounces an extended load balance mannequin for the majority cloud concentrated on the cloud segregating proposal with a swap mechanism to select specific strategies for great occasions.


Author(s):  
Rugui Yao ◽  
Fanqi Gao ◽  
Ling Wang ◽  
Yinghui Wang
Keyword(s):  

Author(s):  
J.E. Azimova ◽  
E.A. Klimov ◽  
E.A. Naumova ◽  
Z.G. Kokaeva ◽  
A.I. Zaitseva ◽  
...  

Перспективным в изучении биомаркеров мигрени может быть многолокусный анализ, в частности, анализ частот сочетанных генотипов. Цель исследования - поиск составных генетических биомаркеров индивидуальной предрасположенности к мигрени, полученных на основе полиморфизмов генов, уже показавших статистическую значимость при однолокусном ассоциативном анализе. Методика. Обследовано 155 пациентов с мигренью (104 пациента с эпизодической мигренью, 51 - с хронической мигренью), наблюдавшихся в Университетской клинике головной боли (Москва). Все пациенты - представители белой расы, жители Московского региона. Возраст пациентов - 30-50 лет. Контроль составили 365 необследованных лиц (популяционный контроль). Выявление исследуемых 22 генов (всего 31 SNP) осуществляли методом ПЦР, ПЦР-ПДРФ, аллель-специфичной ПЦР и ПЦР в реальном времени. Выявление ассоциированных с мигренью сочетанных генотипов проводили с использованием программы анализа полигенных данных APSampler v3.6. Результаты. Выявлено 8 сочетанных генотипов с высокой статистически значимой ассоциацией с мигренью (ОШ>20,0). В состав сочетанных генотипов вошли гены: CCKAR, CCKBR, COMT, MTHFR, MTR, MTRR. Так же выявлено 4 защитных сочетанных генотипа (ОШ<0,02), основным в которых является ген MAOA. Заключение. Полученные данные об ассоциированных с мигренью сочетанных генотипах указывают на значимую роль в патогенезе заболевания 2 биохимических систем: 1) холецистокининергической системы, регулирующей выброс и обратный захват дофамина, и 2) фолатного цикла, в ходе работы которого гомоцистеин метаболизируется в метионин. Результаты, полученные в данном исследовании, позволяют говорить о защитной роли аллеля VNT:R4 гена MAOA.Multilocus analysis, specifically, analysis of combined genotype frequencies may be promising in studying migraine biomarkers. The aim of the study was to search for composite genetic biomarkers, which would predict individual predisposition to migraine, obtained on the basis of gene polymorphisms that have already shown a statistical significance in a single-locus associative analysis. Methods. 155 patients with migraine aging 41.7 ± 12.5 who had been followed up at the University Clinic of Headache, Moscow, were evaluated (104 patients with episodic migraine and 51 with chronic migraine). All patients were white and residents of the Moscow region. The control group included 365 unexamined individuals (population control). Identification of The 22 genes under study (total, 31 SNPs) were identified by PCR, PCR-RFLP, allele-specific PCR, and real-time PCR. Combined genotypes associated with migraine were identified using the APSampler v3.6 software for polygenic data analysis. Results. Eight combined genotypes were identified with a highly significant association with migraine (OR> 20.0). The combined genotypes included the CCKAR, CCKBR, COMT, MTHFR, MTR, and MTRR genes. Four protective combined genotypes were also identified (OS <0.02) with the MAOA gene as the major one. Conclusion. Our data on migraine-associated combined genotypes indicate a significant role in the migraine pathogenesis of two biochemical systems, i) the cholecystokininergic system that regulates the release and reuptake of dopamine, and ii) the folate cycle, where homocysteine is metabolized to methionine. The results obtained in this study suggest a protective role of the VNT: R4 allele of the MAOA gene.


2019 ◽  
Vol 2 (1) ◽  
pp. 43-52
Author(s):  
Alireza Alikhani ◽  
Safa Dehghan M ◽  
Iman Shafieenejad

In this study, satellite formation flying guidance in the presence of under actuation using inter-vehicle Coulomb force is investigated. The Coulomb forces are used to stabilize the formation flying mission. For this purpose, the charge of satellites is determined to create appropriate attraction and repulsion and also, to maintain the distance between satellites. Static Coulomb formation of satellites equations including three satellites in triangular form was developed. Furthermore, the charge value of the Coulomb propulsion system required for such formation was obtained. Considering Under actuation of one of the formation satellites, the fault-tolerance approach is proposed for achieving mission goals. Following this approach, in the first step fault-tolerant guidance law is designed. Accordingly, the obtained results show stationary formation. In the next step, tomaintain the formation shape and dimension, a fault-tolerant control law is designed.


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