Pharmacological Chaperones as Potential Therapeutic Strategies for Misfolded Mutant Vasopressin Receptors

2017 ◽  
pp. 63-83 ◽  
Author(s):  
Bernard Mouillac ◽  
Christiane Mendre
Keyword(s):  
Therapeutic Strategies ◽  
Pharmacological Chaperones ◽  
Vasopressin Receptors

Pharmacological Chaperones: Design and Development of New Therapeutic Strategies for the Treatment of Conformational Diseases

2016 ◽  
Vol 11 (6) ◽  
pp. 1471-1489 ◽  
Author(s):  
Marino Convertino ◽  
Jhuma Das ◽  
Nikolay V. Dokholyan
Keyword(s):  
Therapeutic Strategies ◽  
Design And Development ◽  
Conformational Diseases ◽  
Pharmacological Chaperones

scholarly journals Vasoplegia in patients with sepsis and septic shock: pathways and mechanisms

2018 ◽  
Vol 46 (4) ◽  
pp. 1303-1310 ◽  
Author(s):  
A.-M. Burgdorff ◽  
M. Bucher ◽  
J. Schumann
Keyword(s):  
Inflammatory Mediators ◽  
Animal Studies ◽  
Cardiac Contractility ◽  
Therapeutic Strategies ◽  
Angiotensin Receptors ◽  
Success Rates ◽  
Vasopressin Receptors ◽  
Clinically Significant ◽  
Underlying Mechanisms ◽  
Sepsis And Septic Shock

Sepsis is one of the most frequent causes of death among patients in intensive care units. Many therapeutic strategies have been assessed without the desired success rates. A key risk factor for death is hypotension due to vasodilatation with vascular hyposensitivity. However, the pathways underlying this process remain unclear. Endotoxemia induces inflammatory mediators, and this is followed by vasoplegia and decreased cardiac contractility. Although inhibition of these mediators diminishes mortality rates in animal models, this phenomenon has not been confirmed in humans. Downregulation of vasoconstrictive receptors such as angiotensin receptors, adrenergic and vasopressin receptors is seen in sepsis, which is associated with a hyporesponsiveness to vasoconstrictive mediators. Animal studies have verified that receptor downregulation is linked to the above-mentioned inflammatory mediators. Anti-inflammatory therapy with glucocorticoids reportedly improves responsiveness to catecholamines with higher survival in rats, although this has not been shown to be clinically significant in humans. Hence, there is an urgent need for in-depth studies investigating the underlying mechanisms of vasoplegia to allow for development of effective therapeutic strategies for the treatment of sepsis.

Therapeutic strategies and techniques in early cognitive-behavioral therapy.

Psychotherapy ◽  
2019 ◽  
Vol 56 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Brittany R. King ◽  
James F. Boswell
Keyword(s):  
Cognitive Behavioral Therapy ◽  
Behavioral Therapy ◽  
Therapeutic Strategies ◽  
Cognitive Behavioral

A Comprehensive Review on Diagnostic and Therapeutic Strategies for the Management of Pancreatic Cancer

2020 ◽  
Author(s):  
Vibha Sinha ◽  
Sapnita Shinde ◽  
Saurabh Ssaxena ◽  
Suresh Thakur ◽  
Tamanna Walia ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Therapeutic Strategies ◽  
Comprehensive Review
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