Effects of Iodine-Based Contrast Media on Thyroid Function

2014 ◽  
pp. 157-165
Author(s):  
Aart J. van der Molen
Keyword(s):  
Contrast Media ◽  
Thyroid Function

The influence on thyroid function of two iodine-containing radiological contrast media

1982 ◽  
Vol 55 (652) ◽  
pp. 263-265 ◽  
Author(s):  
C. Jaffiol ◽  
L. Baldet ◽  
M. Bada ◽  
Y. Vierne
Keyword(s):  
Contrast Media ◽  
Thyroid Function

A Prospective Study of the Effect of Nonionic Contrast Media on Thyroid Function

Thyroid ◽  
1996 ◽  
Vol 6 (2) ◽  
pp. 107-110 ◽  
Author(s):  
JENNIFER J. CONN ◽  
MARTIN J. SEBASTIAN ◽  
DAVID DEAM ◽  
MEI TAM ◽  
F.I.R. MARTIN
Keyword(s):  
Contrast Media ◽  
Prospective Study ◽  
Thyroid Function ◽  
Nonionic Contrast Media ◽  
A Prospective Study

Iodine, Thyroid Function, and Very Low Birth Weight Infants

PEDIATRICS ◽  
1996 ◽  
Vol 98 (4) ◽  
pp. 730-734
Author(s):  
Elvira Parravicini ◽  
Corinna Fontana ◽  
Giuseppe L. Paterlini ◽  
Paolo Tagliabue ◽  
Franco Rovelli ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Thyroid Hormones ◽  
Contrast Media ◽  
Thyroid Function ◽  
Very Low Birth Weight ◽  
Urinary Iodine ◽  
Free Triiodothyronine ◽  
Vlbw Infants ◽  
Antiseptic Solutions

Objective. Research was undertaken to test two hypotheses. First, during the early neonatal period, thyroid function of very low birth weight (VLBW) infants is suppressed by exposure to iodine-containing antiseptic solutions and/or iodized contrast media. Second, this suppression is more pronounced in small for gestational age (SGA) infants. Methods. Urinary iodine concentration and thyroid function measurements were obtained prospectively from 44 VLBW infants with gestational ages at birth of 30 ± 2.3 weeks and weights of 1223 ± 231 g. Eleven of these infants were SGA. The infants were grouped according to iodine exposure: 18 infants had no increased exposure and served as control infants; 9 infants were exposed to an iodine-containing antiseptic (povidone iodine); 12 infants were exposed to an iodized contrast medium (iopamidol); and 5 infants were exposed to both agents. Urinary iodine and serum free triiodothyronine, free thyroxine, and thyrotropin were measured on days 1, 7, 14, 21, and 28 of life. Results. During the period of maximum exposure (days 1 to 7), the concentration of iodine in the urine of study infants was 2 to 4 orders of magnitude greater than that in the urine of control infants (123 ± 141 µg/L). During the subsequent 3 weeks, levels of urinary iodine in study infants returned to levels that were not significantly different from controls. On day 7 of life, iodine-exposed infants had a significantly higher mean thyrotropin level than control infants, whereas on day 28, free triiodothyronine and thyroxine levels were lower. Of the 26 iodine-exposed infants, 6 had transient hyperthyrotropinemia and 2 had transient hypothyroidism. When exposed to iodine, SGA infants had more labile thyroid function than normally grown iodine-exposed or control infants. These SGA infants had significantly lower levels of thyroid hormones in umbilical cord blood, increased production of thyroid hormones on day 14 of life, and lower levels again at 1 month. Conclusion. In VLBW infants, the use of iodine-containing antiseptic solutions and iodized contrast media results in massive uptake of iodine that is associated with alterations in thyroid function. It is reasonable to suggest that, whenever possible, iodized products should be avoided in VLBW infants, because their routine use results in exposure to excessive loads of iodine, which can be associated with hyperthyrotropinemia and hypothyroidism.

Iodine contrast prior to or during pregnancy and neonatal thyroid function: a systematic review

2021 ◽  
Vol 184 (1) ◽  
pp. 189-198 ◽  
Author(s):  
Nienke van Welie ◽  
Maite Portela ◽  
Kim Dreyer ◽  
Linda J Schoonmade ◽  
Madelon van Wely ◽  
...  
Keyword(s):  
Systematic Review ◽  
Contrast Media ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast ◽  
Increased Risk ◽  
Neonatal Thyroid Function

Objective Thyroid dysfunction is a known side effect of iodinated contrast media. There is some evidence to suggest that iodinated contrast media administered to pregnant women may cause thyroid dysfunction not only in themselves but also in their offspring. Here, we systematically evaluated literature on the use of iodinated contrast media prior to or during pregnancy on the offspring’s thyroid function. Design Systematic review of published literature. Materials and methods Relevant studies were identified by PubMed, EMBASE and The Cochrane Library up to June 5, 2020. All study designs, reporting on the foetal or neonatal thyroid function after exposure to iodinated contrast media prior to or during pregnancy, were included. We undertook random effects meta-analysis and pooled the estimates as proportions with 95% CIs. Results We identified 402 articles, of which 26 were included. Six studies reported (n = 369) on exposure to iodinated contrast media prior to pregnancy by hysterosalpingography and 20 studies (n = 670) on exposure to these media during pregnancy by amniofetography, urography or CT. There was low to high risk of bias. The proportion of (transient) neonatal thyroid dysfunction was 0.0% (95% CI: 0.0–2.9% based on 3 studies) for hysterosalpingography, 2.25% (95% CI: 0.03–6.55% based on 2 studies) for amniofetography and 0.0% (95% CI: 0.0–0.02% based on 5 studies) for CT. There was a tendency towards an increased risk of thyroid dysfunction with higher amounts of contrast used. Conclusions Exposure to iodinated contrast media prior to or during pregnancy may increase the risk of thyroid dysfunction in offspring. We recommend keeping the amount of contrast used as low as possible.

scholarly journals Iodinated contrast media and their effect on thyroid function – Routines and practices among diagnostic imaging departments in Norway

2020 ◽  
Vol 67 (2) ◽  
pp. 111-118
Author(s):  
Albertina Rusandu ◽  
Bjørnar Heggdal Sjøvold ◽  
Edvin Hofstad ◽  
Randi Johansen Reidunsdatter
Keyword(s):  
Diagnostic Imaging ◽  
Contrast Media ◽  
Thyroid Function ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast

scholarly journals Effect of Contrast Media used in Coronary Angiography on Thyroid Function

2019 ◽  
pp. 339-344
Author(s):  
Khaled S. El-Hadidy ◽  
Rania E. Sheir ◽  
M.N. Salem ◽  
Ahmed M. EL-Dien ◽  
Yasser A. Abd El-Hady
Keyword(s):  
Coronary Angiography ◽  
Contrast Media ◽  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Thyroid Stimulating Hormone ◽  
P Value ◽  
Free T4 ◽  
Iodinated Contrast ◽  
Significant Difference

Radiocontrast-induced thyroid dysfunction prevalence has not been assessed accurately. It is greater among patients with pre-existing thyroid disease. Aim of this work to investigate effect of iodinated radiographic contrast media used in coronary angiography on the thyroid function in euthyroid patients. This study was conducted on 85 patients underwent elective coronary angiography. Baseline assessment of Free Thyroxine (FT4) and Thyroid-stimulating hormone (TSH) for the patients and three months later after Coronary Angiography. We observed that there was a statistically significant increase of TSH levels from baseline till 3 months following administration of contrast media (P-value=0.007). However, there was no statistical significant difference of Free T4 level from baseline till 3 (P-value=0.765). The incidence of increased TSH above normal range was 2.4% after 3 months ( 2 subclinical hypothyroidism cases). We noticed that there were no effect of age, gender, hypertension, diabetes, type of contrast, creatinine level or GFR on increased the level of TSH above normal value after 3 months. So, administration of Iodinated Contrast Media (ICM) associated with thyroid dysfunction mainly subclinical hypothyroidism so we should closely monitor patients after receiving ICM especially who have thyroid dysfunction.

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